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Molecular Interactions of Actin pp 181–199Cite as

Actin Filament Networks

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 32))

Abstract

Since its discovery as an essential component of the contractile machinery of striated muscle, the ability of purified actin to increase the viscosity of its aqueous solutions has been the object of many studies. Biochemical and biophysical studies soon established that the chemical stimuli, usually addition of monovalent or divalent salts, that increased viscosity did so coincident with promoting the polymerization of globular (G-) actin into filamentous polymers (F-actin). Defining how the properties of the individual filaments and their interactions with each other account for the macroscopic mechanical properties of F-actin solutions is an active area of research, with several fundamental questions remaining unanswered.

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Authors and Affiliations

  1. Hematology Division, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Ave., LMRC 301, Boston, Massachussetts, 02115, USA

    Thomas P. Stossel

  2. Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachussetts, 02138, USA

    Thomas P. Stossel

  3. Institute for Medicine and Engineering (IME), University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA, 19104, USA

    Paul A. Janmey

  4. Ludwig Institute for Cancer Research, University of California, San Diego, 9500 Gilman Drive, CMM-East 3080 - MAIL CODE 0660, La Jolla, CA, 92093, USA

    Jagesh V. Shah

  5. Physics Department, Indiana University, Swain West 165, 727 East Third St, Bloomington, IN, 47405, USA

    Jay X. Tang

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  1. Paul A. Janmey
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  2. Jagesh V. Shah
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  4. Thomas P. Stossel
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Editors and Affiliations

  1. Department of Anatomy and Histology, Institute for Biomedical Research, University of Sydney, 2006, Sydney, Australia

    Cristobal G. dos Remedios

  2. Department of Biochemistry, University of Minnesota, 55455, Minneapolis, MN, USA

    David D. Thomas

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© 2001 Springer-Verlag Berlin Heidelberg

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Janmey, P.A., Shah, J.V., Tang, J.X., Stossel, T.P. (2001). Actin Filament Networks. In: dos Remedios, C.G., Thomas, D.D. (eds) Molecular Interactions of Actin. Results and Problems in Cell Differentiation, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46560-7_13

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