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Histological Classification of Breast Cancer

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Breast Cancer

Abstract

Cancer of the breast is one of the most common human neoplasms, accounting for one quarter of all cancers in females. It is associated with the western life style. Risk factors include early menarche and late childbirth. Breast cancer is further characterized by a marked genetic susceptibility. The typing of invasive breast cancer, its histological variants and their grading systems are well established. More difficult is the classification of the pre-invasive breast lesions that are now increasingly detected by mammography.

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References

  • Balzi D, Buiatti E, Geddes M, Khlat M, Masuyer E, Parkin DM (2003) Summary of the results by site. In: Cancer in Italian migrant populations, IARC Scientific Publication, International Agency for Research on Cancer: Lyon, 123:193–292

    Google Scholar 

  • Bratthauer GL, Tavassoli FA (2002) Lobular neoplasia: previously unexplored aspects assessed in 775 cases and their clinical Implication. Virchows Arch 440: 134–138

    Article  PubMed  Google Scholar 

  • Bloom HJ, Richardson WW (1957) Histological grading and prognosis in breast cancer. Br J Cancer 11: 359–377

    PubMed  CAS  Google Scholar 

  • Buell P (1973) Changing incidence of breast cancer in Japanese-American women. J Natl Cancer Inst 51: 1479–1483

    PubMed  CAS  Google Scholar 

  • Cohen C, Guarner J, DeRose PB (1993) Mammary Paget’s disease and associated carcinoma. An immunohistochemical study. Arch Pathol Lab Med 117: 291–294

    PubMed  CAS  Google Scholar 

  • Dina R, Eusebi V (1997) Clear cell tumors of the breast. Semin Diagn Pathol 14: 175–182

    PubMed  CAS  Google Scholar 

  • Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology 19: 403–410

    Article  PubMed  CAS  Google Scholar 

  • Elston CW, Ellis IO (1998) Classification of malignant breast disease. In: The breast systemic pathology. Edinburgh, Churchill Livingstone, pp 239–247

    Google Scholar 

  • Fechner RE (1975) Histologic variants of infiltrating lobular carcinoma of the breast. Hum Pathol 6: 373–378

    Article  PubMed  CAS  Google Scholar 

  • Feyrter F, Hartmann G (1963) Uber die carcinoide Wuchsform des Carcinoma mammae, insbesondere das Carcinoma solidum (gelatinosum) mamma. Fradf Z Pathol 73: 24–30

    CAS  Google Scholar 

  • Fisher ER, Gregorio RM, Redmond C, Fisher B (1977) Tubulolobular invasive breast cancer: a variant of lobular invasive cancer. Hum Pathol 8: 679–683

    Article  PubMed  CAS  Google Scholar 

  • Frable WJ, Kays S (1968) Carcinoma of the breast. Histologic and clinical features of apocrine tumors. Cancers 21:756–763

    Article  CAS  Google Scholar 

  • Gupta RK (1996) Aspiration cytodiagnosis of a rare carcinoma of breast with bizarre malignant giant cells. Diagn Cytopathol 15: 66–69

    Article  PubMed  CAS  Google Scholar 

  • Holland R, Peterse JL, Mills RR, Eusebi V, Faverly D, van de Vijver MJ, Zafrani B (1994) Ductal carcinoma in situ: a proposal for a new classification. Sem Diagn Pathol 3:167–180

    Google Scholar 

  • Horne CH, Reid IN, Milne GD (1976) Prognostic significance of inappropriate production of pregnancy proteins by breast cancers. Lancet 2: 2769–282

    Google Scholar 

  • Hull MT, Warkel KA (1986) Glyocogen-rich clear cell carcinomas of the breast. A clinicopathologic and ultrastructural study. Am J Surg Pathol 10: 553–559

    Article  PubMed  CAS  Google Scholar 

  • Huvos AG, Lucas JC Jr, Foote FW Jr (1973) Metaplastic breast carcinoma. Rare form of mammary cancer. N Y State J Med 73: 1078–1082

    PubMed  CAS  Google Scholar 

  • Kaufman MW, Marti JR, Gallager HS, Hoehn JL (1984) Carcinoma of the breast with pseudosarcomatous metaplasia. Cancer 53: 1908–1917

    Article  PubMed  CAS  Google Scholar 

  • Kelsey JL, Gammon MD, John EM (1993) Reproductive factors and breast cancer. Epidemiol Rev 15: 36–47

    PubMed  CAS  Google Scholar 

  • Kliewer EV, Sith KE (1995) Breast cancer mortality among immigrants in Australia and Canada. J Natl Cancer Inst 87: 1154–1161

    Article  PubMed  CAS  Google Scholar 

  • Kollias J, Elston CW, Ellis IO, Robertson JF, Blamey RW (1997) Early-onset breast cancer-histopathological and prognostic considerations. Br J Cancer 75: 1318–1323

    PubMed  CAS  Google Scholar 

  • Lamovec J, Us-Krasovec M, Zidar A, Kljun A (1989) Adenoid cystic carcinoma of the breast: a histologic, cytologic, and immunohistochemical study. Semin Diagn Pathol 6: 153–164

    PubMed  CAS  Google Scholar 

  • Leal C, Costa I, Fonseca D, Lopes P, Bento MJ, Lopes C (1998) Intracystic (encysted) papillary carcinoma of the breast: a clinical, pathological, and immunohistochemical study. Hum Pathol 29: 1097–1104

    Article  PubMed  CAS  Google Scholar 

  • Marcus JN, Watson P, Page DL, Narod SA, Lenoir GM, Tonin P, Linder-Stepherson L, Salerno G, Conway TA, Lynch HT (1996) Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage. Cancer 77: 697–709

    Article  PubMed  CAS  Google Scholar 

  • Martinez V, Azzopardi JG (1979) Invasive lobular carcinoma of the breast: incidence and variants. Histopathology 3:467–488

    Article  PubMed  CAS  Google Scholar 

  • Mazoujian G, Pinkus GS, Davis S, Haagensen DE Jr (1983) Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features. Am J Pathol 110: 105–112

    PubMed  CAS  Google Scholar 

  • Papadatos, g, Rangan AM, Psarianos T, Ung O, Taylor R, Boyages J (2001) Probability of axillary node involvement in patients with tubular carcinoma of the breast. Br J Surg 88: 860–864

    Article  PubMed  CAS  Google Scholar 

  • Parkin DM, Stjernsward J, Muir CS (1984) Estimates of worldwide frequency of 12 major cancers. Bull World Health Org 62: 163–182

    PubMed  CAS  Google Scholar 

  • Parkin DM, Bra F, Ferlay J, Pisani P (2001) Estimating the world cancer burden. Globocan 2000. Int J Cancer 94:153–156

    Article  PubMed  CAS  Google Scholar 

  • Parkin DM, Whelan SL, Ferlay J Raymond L, Young J (2001) Cancer incidence in five continents, Vol VII (IARC Scientific Publication n. 143). Lyon, Fance, International Agency for Research on Cancer: Lyon, France

    Google Scholar 

  • Patchefsky AS, Shaber GS, Schwartz GF, Feig SA, Nerlinger RE (1977) The pathology of breast cancer detected by mass population screening. Cancer 40: 1659–1670

    Article  PubMed  CAS  Google Scholar 

  • Paterakos M, Watkin WG, Edgerton SM, Moore DH, Thor AD (1999) Invasive micropapillary carcinoma of the breast. A prognostic study. Hum Pathol 30: 1459–1463

    Article  PubMed  CAS  Google Scholar 

  • Ponsky JL, Gliga L, Reynolds S (1984) Medullary carcinoma of the breast: an association with negative hormonal receptors. J Surg Oncol 25: 76–78

    Article  PubMed  CAS  Google Scholar 

  • Prentice RL, Kakar F, Hursting S, Sheppard L, Klein R, Kushi LH (1988) Aspects of the rationale for the women’s health trial. J Natl Cancer Inst 80: 802–814

    Article  PubMed  CAS  Google Scholar 

  • Ridolfi RL, Rosen PP, Port A, Kinne D, Mike V (1977) Medullary carcinoma of the breast: a clinicopathologic study with 10 year follow-up. Cancer 40: 1365–1385

    Article  PubMed  CAS  Google Scholar 

  • Robbins P, Pinder S, de Klerk N, Dawkins H, Harvey J, Sterret G, Ellis I, Elston C (1995) Histological grading of breast carcinomas: a study of interobserver agreement. Hum Pathol 26: 873–879

    Article  PubMed  CAS  Google Scholar 

  • Rosen PP, Oberman HA (1992) Tumors of the mammary gland. In: Atlas of tumor pathology, AFIP

    Google Scholar 

  • Rosen PP (1997) Rosen’s breast pathology. Lippincott-Raven, Philadelphia

    Google Scholar 

  • Rosen PP (2001) Rosen’s breast pathology. Lippincott William and Wilkins, Philadelphia

    Google Scholar 

  • Sastre-Garau X, Jouve M, Asselain T, Durand JC, Fourquet A, Pouillart P (1996) Infiltrating lobular carcinoma of the breast. Clinicopathologic analysis of 975 cases with reference to data on conservative therapy and metastatic patterns. Cancer 77: 113–120

    Article  PubMed  CAS  Google Scholar 

  • Schneider JA (1989) Invasive papillary breast carcinoma: mammographic and sonographic appearance. Radiology 171: 377–379

    PubMed  CAS  Google Scholar 

  • Scopsi L, Andreola S, Pilotti S, Bufalino R, Baldini MT, Testori A, Rilke F (1994) Mucinous carcinoma of the breast. A clinicopathologic, histochemical, and immunocytochemical study with special reference to neuroendocrine differentiation. Am J Surg Pathol 18: 702–711

    Article  PubMed  CAS  Google Scholar 

  • Shousha S, Backhous Cm, Alaghband-Zadeh J, Burn I (1986) Alveolar variant of invasive lobular carcinoma of the breast. A tumor rich in estrogen receptors. Am J Clin Pathol 85: 1–5

    PubMed  CAS  Google Scholar 

  • Shousha S, Coady AT, Stamp T, James KR, Alaghbadn-Zadeh J (2989). Oestrogen receptors in mucinouc carcinoma of the breast: an immunohistochemical study using paraffin wax sections. J Clin Pathol 42: 902–905

    Article  Google Scholar 

  • Silver SA, Tavassoli FA (2000) Pleomorphic carcinoma of the breast: clinicopathological analysis of 26 cases of an unusual high-grade phenotype of ductal carcinoma. Histopathology 36: 505–514

    Article  PubMed  CAS  Google Scholar 

  • Singletary SE, Connolly JL (2006) Breast cancer staging: Working with the 6th edition of the AJCC cancer staging manual. CA Cancer J Clin 56: 37–47

    Article  PubMed  Google Scholar 

  • Sobin LH, Witekind CH (2002) TNM, classification of malignant tumours. Uicc, Wiley-Liss, New York

    Google Scholar 

  • Soomro S, Shousha S, Taylor P, Shepard HM, Feldmann M (1991) c-erbB-2 expression in different histological types of invasive breast carcinoma. J Clin Pathol 44:211–214

    Article  PubMed  CAS  Google Scholar 

  • Tavassoli FA, Devilee P (2003) Pathology and genetics. Tumours of the breast and female genital organs: In: World Health Organization classification of tumours 2001, Lyon

    Google Scholar 

  • Venable JG, Schwartz AM, Silverberg SG (1990) Infiltrating cribiform carcinoma of the breast: a distinctive clinicopathologic entity. Hum Pathol 21: 333–338

    Article  PubMed  CAS  Google Scholar 

  • Wargotz ES, Norris HJ (1990) Metaplastic carcinoma of ductal origin. Cancer 65: 272–276

    Article  PubMed  CAS  Google Scholar 

  • Wargotz ES, Silverberg SG (1988) Medullary carcinoma of the breast: a clinicopathologic study with appraisal of current diagnostic criteria. Hum Pathol 19: 1340–1346

    Article  PubMed  CAS  Google Scholar 

  • Weidner N, Semple JP (1992) Pleomorphic variant of invasive lobular carcinoma of the breast. Hum Pathol 23: 1167–1171

    Article  PubMed  CAS  Google Scholar 

  • Winchester DJ, Chang HR, Gravies Ta, Menck HR, Bland KL, Winchester DP (1998) A comparative analysis of lobular and ductal carcinoma of the breast: presentation, treatment, and outcomes. J Am Coll Surg 186: 416–422

    Article  PubMed  CAS  Google Scholar 

  • Ziegler RG, Hoover RN, Pike MC, Hildesheim A, Nomura AMM, West DW, Wu-Williams AH, Koloner LN, Horn-Ross PL, Rosentahal JF, Hyer MB (1993) Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst 85: 1819–1827

    Article  PubMed  CAS  Google Scholar 

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Fabbri, A., Carcangiu, M.L., Carbone, A. (2008). Histological Classification of Breast Cancer. In: Bombardieri, E., Gianni, L., Bonadonna, G. (eds) Breast Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-36781-9_2

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  • DOI: https://doi.org/10.1007/978-3-540-36781-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-36780-2

  • Online ISBN: 978-3-540-36781-9

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