Synonyms
Phenacetin nephritis
Definition and Characteristics
A slowly progressive decline in renal function secondary to chronic regular use of analgesic medications. Histology classically shows renal papillary necrosis and chronic interstitial nephritis.
Prevalence
Phenacetin-containing analgesics were initially implicated as the cause of analgesic nephropathy; this led to the withdrawal of phenacetin from the market in many industrialized nations during the 1980s. The general prevalence of analgesic nephropathy in these nations is estimated to be 1–5%. In nations such as Sweden in which over-the-counter sales of analgesic mixtures have also been banned, this prevalence is even lower. Eastern European countries are noted to have higher prevalence rates, presumably related to higher sales of analgesic mixtures. Though the majority of the epidemiological studies are methodologically flawed, lifetime cumulative intake of analgesics seems to correlate with increased incidence of end-stage...
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References
Harris R (2000) Cyclooxygenase-2 in the kidney. J Am Soc Nephrol 11:2387–2394
Gault M, Shadhidi N (1974) Methemoblogin formation in analgesic nephropathy. Clin Pharmacol Ther 15:521–527
Duggin G (1996) Combination analgesic-induced kidney disease: the Australian experience. Am J of Kidney Dis 28:S39–S47
Whelton A (1999) Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications. Am J Med 106:13S–24S
Elseviers M, De Schepper A, Corthouts R et al. (1995) High diagnostic performance of CT scan for analgesic nephropathy in patients with incipient to severe renal failure. Kidney Int 48:1316–1323
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© 2009 Springer-Verlag GmbH Berlin Heidelberg
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Estrella, M.M., Atta, M.G. (2009). Analgesic Nephropathy. In: Lang, F. (eds) Encyclopedia of Molecular Mechanisms of Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29676-8_100
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DOI: https://doi.org/10.1007/978-3-540-29676-8_100
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-67136-7
Online ISBN: 978-3-540-29676-8
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