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Generation and Gene Expression of CD28−CD8 T Cells in Human

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Handbook of Immunosenescence

Abstract

Increase of CD28−CD8 T cells is one of the hallmarks of aging in the human immune system. Recent studies reveal the mechanism of generation and gene expression features of CD28−CD8 T cells. Here, we focus on the role of interleukin-15 (IL-15) in the generation of CD28−CD8 T cells and the identification of unique gene expression in CD28−CD8 T cells by microarray gene expression analysis. These new findings enhance our understanding of the origin and function of the CD28−CD8 T cells and may provide new means for clinical intervention.

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Acknowledgements

The authors want to thank Monchou Fann, Kevin Becker, and William Wood III for conducting and assisting in the microarray experiments; Karen Chiu and Jason Godlove for the study of IL-15 induced down-regulation of CD28 expression; Robert Wersto, Joe Chrest, and Coung Nguyen for cell sorting; and Karen Madara and her staff at the NIA Apheresis Unit for processing the blood samples. This research was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health (NIH).

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  1. Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA

    Jaekwan Kim & Nan-ping Weng

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  1. Jaekwan Kim
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  2. Nan-ping Weng
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Correspondence to Nan-ping Weng .

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Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Department of Medicine, Sherbrooke, QC, Canada

    Tamas Fulop

  2. Department of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

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  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

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Kim, J., Weng, Np. (2019). Generation and Gene Expression of CD28−CD8 T Cells in Human. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-99375-1_17

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