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Nanoparticles as Radiopharmaceutical Vectors

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Abstract

This chapter summarizes the use of nanoparticles for the delivery of radionuclides for nuclear imaging and therapy. Due to their modularity and flexibility, radiolabeled nanoparticles have the potential to play a key role in the diagnosis and management of cancer in the near future. Currently, however, the development and clinical implementation of radiolabeled nanoparticles faces several major challenges, including improving their targeting efficiency, developing robust methods for both the encapsulation/integration of radionuclides and the conjugation of targeting ligands, achieving favorable safety profiles, and overcoming regulatory concerns. When nanoparticles are able to overcome these roadblocks, they have the chance to become integral tools in the landscape of nuclear medicine.

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Authors and Affiliations

  1. School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand

    Anyanee Kamkaew

  2. Department of Medical Physics, University of Wisconsin – Madison, Madison, WI, USA

    Emily B. Ehlerding

  3. Department of Radiology, University of Wisconsin – Madison, Madison, WI, USA

    Weibo Cai

Authors
  1. Anyanee Kamkaew
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  2. Emily B. Ehlerding
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  3. Weibo Cai
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Corresponding authors

Correspondence to Anyanee Kamkaew or Weibo Cai .

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Editors and Affiliations

  1. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Jason S. Lewis

  2. Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

    Albert D. Windhorst

  3. Department of Chemistry, Hunter College, City University of New York, New York, NY, USA

    Brian M. Zeglis

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Kamkaew, A., Ehlerding, E.B., Cai, W. (2019). Nanoparticles as Radiopharmaceutical Vectors. In: Lewis, J., Windhorst, A., Zeglis, B. (eds) Radiopharmaceutical Chemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-98947-1_10

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  • DOI: https://doi.org/10.1007/978-3-319-98947-1_10

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