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Alcohol and Cancer pp 71–79Cite as

Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1032))

Abstract

HCC is a rapidly increasing cancer worldwide. Most HCC rises in the setting of chronic and advanced liver disease caused by viral hepatitis, alcohol use, non-alcoholic liver disease or their combination. We found that in the mouse model, alcohol alone does not induce HCC, however, it can promote HCC development after a carcinogen exposure. Multiple mechanisms are involved in carcinogenesis and alcohol affects many of those including epithelial-mesenchymal transition, cancer stem marker expression and inflammation as evidenced in our HCC model.

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Funding

NIH NIAAA R01 AA011576 to G.S.

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Authors and Affiliations

  1. Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA

    Gyongyi Szabo

Authors
  1. Gyongyi Szabo
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Corresponding author

Correspondence to Gyongyi Szabo .

Editor information

Editors and Affiliations

  1. Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA

    Vasilis Vasiliou

  2. Distilled Spirits Council of the US, Washington, DC, USA

    Samir Zakhari

  3. Mishra Laboratory, University of Texas, MD Anderson Cancer Center, Houston, TX, USA

    Lopa Mishra

  4. Salem Medical Centre, University of Heidelberg, Heidelberg, Baden-Württemberg, Germany

    Helmut K. Seitz

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Szabo, G. (2018). Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model. In: Vasiliou, V., Zakhari, S., Mishra, L., Seitz, H. (eds) Alcohol and Cancer. Advances in Experimental Medicine and Biology, vol 1032. Springer, Cham. https://doi.org/10.1007/978-3-319-98788-0_5

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