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The Adenosine Receptors pp 439–460Cite as

Adenosine Signalling in the Injured Heart

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Part of the book series: The Receptors ((REC,volume 34))

Abstract

Adenosine plays a prominent role in the cardiovascular system and has been extensively studied for both its therapeutic and diagnostic abilities. This chapter reviews the various sources and metabolic pathways of adenosine formation in the heart. Depending on the individual cell type involved (cardiomyocyte, vascular smooth muscle cell, coronary endothelium, pericyte, fibroblast and cells of cardiac impulse generation and propagation) together with the cell-specific expression pattern of the four adenosine receptors, adenosine importantly regulates key parameters of cardiac function and energy supply including contractility, heart rate, coronary flow and substrate utilization. In the infarcted heart, recent evidence indicates that adenosine formed by CD73 on T cells and epicardial mesenchymal cells critically modulates central processes of cardiac inflammation, post-MI remodelling/fibrosis, regeneration and tissue protection. Since the A2BR appears to be linked to IL6 formation, the adenosine-IL6 axis may be a promising target for the therapy of post-MI inflammation, remodelling and fibrosis.

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Authors and Affiliations

  1. Department of Molecular Cardiology, Heinrich-Heine-University, Düsseldorf, Germany

    Julia Hesse, Christina Alter & Jürgen Schrader

Authors
  1. Julia Hesse
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  2. Christina Alter
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  3. Jürgen Schrader
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Correspondence to Jürgen Schrader .

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Editors and Affiliations

  1. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Pier Andrea Borea

  2. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Katia Varani

  3. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Stefania Gessi

  4. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Stefania Merighi

  5. Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Fabrizio Vincenzi

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Hesse, J., Alter, C., Schrader, J. (2018). Adenosine Signalling in the Injured Heart. In: Borea, P., Varani, K., Gessi, S., Merighi, S., Vincenzi, F. (eds) The Adenosine Receptors. The Receptors, vol 34. Humana Press, Cham. https://doi.org/10.1007/978-3-319-90808-3_17

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