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An Overview of Hemostasis

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Congenital Bleeding Disorders

Abstract

Hemostasis is a physiological well-controlled complex process in the body in which the integrity of the circulatory system is maintained after vascular injury. This process has three main components including vascular system, cellular components, and noncellular components. These three components closely work together to keep the hemostasis system in the best situation.

Hemostasis is comprised of two arms: primary hemostasis and secondary hemostasis. Primary hemostasis using vascular endothelial cells and platelets leads to unstable hemostatic platelet plug formation. In secondary hemostasis, coagulation cascade activation results in stable fibrin clot formation. Overall, hemostasis causes bleeding to stop from the injured site. Natural anticoagulants are necessary to limit clot formation process at the injured site. The formed clot is required to be removed after healing process to restore blood flow. The fibrinolysis system is one of the most important requirements for clot removal. Procoagulant and anticoagulant elements interacted complicatedly to ensure an effective response to vascular injury that is limited to the injured site.

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Author information

Authors and Affiliations

  1. Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

    Akbar Dorgalaleh & Maryam Daneshi

  2. Tehran Heart Center, Tehran, Iran

    Jamal Rashidpanah

  3. Tehran, Iran

    Elaheh Roshani Yasaghi (Independent researcher)

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  1. Akbar Dorgalaleh
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  2. Maryam Daneshi
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  3. Jamal Rashidpanah
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  4. Elaheh Roshani Yasaghi
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Editors and Affiliations

  1. Iran University of Medical Sciences, Departement of Hematology and Blood TransfusionSchool of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

    Akbar Dorgalaleh

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Dorgalaleh, A., Daneshi, M., Rashidpanah, J., Roshani Yasaghi, E. (2018). An Overview of Hemostasis. In: Dorgalaleh, A. (eds) Congenital Bleeding Disorders . Springer, Cham. https://doi.org/10.1007/978-3-319-76723-9_1

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  • DOI: https://doi.org/10.1007/978-3-319-76723-9_1

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  • Online ISBN: 978-3-319-76723-9

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