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Development of Bioactive Tellurite-Lanthanide Ions–Reinforced Hydroxyapatite Composites for Biomedical and Luminescence Applications

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Tellurite Glass Smart Materials

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Abstract

Human skeletal bone loss is a major health concern in the twenty-first century, with massive socioeconomic implications. The objective of the current work is to develop and characterize bioactive tellurite glasses for biomedical applications. As so, tellurium oxide- (TeO2) and lanthanide (Ln3+)-doped borate host systems have been developed and incorporated in a hydroxyapatite (HA) matrix, being adequately characterized regarding solid-state parameters and for in vitro biological response. In the proposed work, the following scientific questions will be addressed: Will the reported tellurite-lanthanide (Te-Ln3+) host glass-reinforced hydroxyapatite (HA) ceramic materials influence the cell behavior, such as proliferation and differentiation? Does this Te-Ln material show any luminescence response? Further, the research on lanthanide-based materials is promising, with potential application in prospective medical applications. Consequently, investigation into the role of Te-Ln3+-HA host scaffold materials for bone repair is a relatively new approach that deserves a special attention.

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Acknowledgment

The authors (SHN and AS) would like to thank the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 753636.

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Authors and Affiliations

  1. School of Metallurgy and Materials, University of Birmingham, Edgbaston, Birmingham, UK

    S. H. Nandyala & A. Stamboulis

  2. Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, Rua Dr. Manuel Pereira da Silva, Porto, Portugal

    P. S. Gomes, L. Grenho & M. H. Fernandes

  3. REQUIMTE/LAQV – University of Porto, Porto, Portugal

    P. S. Gomes, L. Grenho & M. H. Fernandes

  4. HORIBA Jobin Yvon IBH Ltd, Glasgow, UK

    G. Hungerford

Authors
  1. S. H. Nandyala
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  2. P. S. Gomes
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  3. G. Hungerford
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  4. L. Grenho
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  5. M. H. Fernandes
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  6. A. Stamboulis
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Corresponding author

Correspondence to S. H. Nandyala .

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Editors and Affiliations

  1. Physics Department, Faculty of Science, Menoufia University, Shebin ElKoum, Egypt

    Raouf El-Mallawany

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Nandyala, S.H., Gomes, P.S., Hungerford, G., Grenho, L., Fernandes, M.H., Stamboulis, A. (2018). Development of Bioactive Tellurite-Lanthanide Ions–Reinforced Hydroxyapatite Composites for Biomedical and Luminescence Applications. In: El-Mallawany, R. (eds) Tellurite Glass Smart Materials. Springer, Cham. https://doi.org/10.1007/978-3-319-76568-6_12

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