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Sleep-Disordered Breathing and Sleep Duration in Childhood Obesity

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

The increasing prevalence of childhood obesity during the past generation has been accompanied by profound changes in daily lifestyle. Computer-related activities, video games, cell phones, and other diversions have promoted a more sedentary existence, reducing energy expenditure and facilitating weight gain. Much of the screen and cell time is spent during the evening hours at the expense of sleep. Thus, behaviors that foster the development and progression of obesity in children may disrupt fundamental biological rhythms that are vital to child and adolescent health.

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References

  1. Kaditis AG, Alonso Alvarez ML, Boudewyns A, et al. Obstructive sleep disordered breathing in 2- to 18-year-old children: diagnosis and management. Eur Respir J. 2016;47:69–94.

    Article  PubMed  Google Scholar 

  2. Corbo GM, Forastiere F, Agabiti N, et al. Snoring in 9- to 15-year-old children: risk factors and clinical relevance. Pediatrics. 2001;108:1149–54.

    Article  CAS  PubMed  Google Scholar 

  3. Urschitz MS, Eitner S, Wolff J, et al. Risk factors for sleep-related hypoxia in primary school children. Pediatr Pulmonol. 2007;42:805–12.

    Article  PubMed  Google Scholar 

  4. Redline S, Tishler PV, Schluchter M, et al. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med. 1999;159:1527–32.

    Article  CAS  PubMed  Google Scholar 

  5. Rosen CL, Larkin EK, Kirchner HL, et al. Prevalence and risk factors for sleep-disordered breathing in 8- to 11-year-old children: association with race and prematurity. J Pediatr. 2003;142:383–9.

    Article  PubMed  Google Scholar 

  6. Sanchez-Armengol A, Fuentes-Pradera MA, Capote-Gil F, et al. Sleep-related breathing disorders in adolescents aged 12 to 16 years: clinical and polygraphic findings. Chest. 2001;119:1393–400.

    Article  CAS  PubMed  Google Scholar 

  7. Verhulst SL, Van Gaal L, De Backer W, et al. The prevalence, anatomical correlates and treatment of sleep-disordered breathing in obese children and adolescents. Sleep Med Rev. 2008;12:339–46.

    Article  PubMed  Google Scholar 

  8. Peppard PE, Young T, Palta M, et al. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000;284:3015–21.

    Article  CAS  PubMed  Google Scholar 

  9. Marcus CL, Curtis S, Koerner CB, et al. Evaluation of pulmonary function and polysomnography in obese children and adolescents. Pediatr Pulmonol. 1996;21:176–83.

    Article  CAS  PubMed  Google Scholar 

  10. Verhulst SL, Schrauwen N, Haentjens D, et al. Sleep-disordered breathing in overweight and obese children and adolescents: prevalence, characteristics and the role of fat distribution. Arch Dis Child. 2007;92:205–8.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kohler M, Lushington K, Couper R, et al. Obesity and risk of sleep related upper airway obstruction in Caucasian children. J Clin Sleep Med. 2008;4:129–36.

    PubMed  PubMed Central  Google Scholar 

  12. Chay OM, Goh A, Abisheganaden J, et al. Obstructive sleep apnea syndrome in obese Singapore children. Pediatr Pulmonol. 2000;29:284–90.

    Article  CAS  PubMed  Google Scholar 

  13. Silvestri JM, Weese-Mayer DE, Bass MT, et al. Polysomnography in obese children with a history of sleep-associated breathing disorders. Pediatr Pulmonol. 1993;16:124–9.

    Article  CAS  PubMed  Google Scholar 

  14. Brooks LJ, Stephens BM, Bacevice AM. Adenoid size is related to severity but not the number of episodes of obstructive apnea in children. J Pediatr. 1998;132:682–6.

    Article  CAS  PubMed  Google Scholar 

  15. Schafer H, Pauleit D, Sudhop T, et al. Body fat distribution, serum leptin, and cardiovascular risk factors in men with obstructive sleep apnea. Chest. 2002;122:829–39.

    Article  PubMed  Google Scholar 

  16. Grunstein R, Wilcox I, Yang TS, et al. Snoring and sleep apnoea in men: association with central obesity and hypertension. Int J Obes Relat Metab Disord. 1993;17:533–40.

    CAS  PubMed  Google Scholar 

  17. Levinson PD, McGarvey ST, Carlisle CC, et al. Adiposity and cardiovascular risk factors in men with obstructive sleep apnea. Chest. 1993;103:1336–42.

    Article  CAS  PubMed  Google Scholar 

  18. Vgontzas AN, Papanicolaou DA, Bixler EO, et al. Sleep apnea and daytime sleepiness and fatigue relation to visceral obesity insulin resistance and hypercytokinemia. J Clin Endocrinol Metab. 2000;85:1151–8.

    Article  CAS  PubMed  Google Scholar 

  19. Carotenuto M, Bruni O, Santoro N, et al. Waist circumference predicts the occurrence of sleep-disordered breathing in obese children and adolescents: a questionnaire-based study. Sleep Med. 2006;7:357–61.

    Article  PubMed  Google Scholar 

  20. Li AM, Chan MH, Chan DF, et al. Insulin and obstructive sleep apnea in obese Chinese children. Pediatr Pulmonol. 2006;41:1175–81.

    Article  PubMed  Google Scholar 

  21. Canapari CA, Hoppin AG, Kinane TB, et al. Relationship between sleep apnea, fat distribution, and insulin resistance in obese children. J Clin Sleep Med. 2011;7:268–73.

    PubMed  PubMed Central  Google Scholar 

  22. Fregosi RF, Quan SF, Kaemingk KL, et al. Sleep-disordered breathing, pharyngeal size and soft tissue anatomy in children. J Appl Physiol (1985). 2003;95:2030–8.

    Article  CAS  Google Scholar 

  23. Arens R, Sin S, Nandalike K, et al. Upper airway structure and body fat composition in obese children with obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 2011;183:782–7.

    Article  PubMed  Google Scholar 

  24. Lavie L. Obstructive sleep apnoea syndrome—an oxidative stress disorder. Sleep Med Rev. 2003;7:35–51.

    Article  PubMed  Google Scholar 

  25. Van Hoorenbeeck K, Franckx H, Debode P, et al. Weight loss and sleep-disordered breathing in childhood obesity: effects on inflammation and uric acid. Obesity (Silver Spring). 2012;20:172–7.

    Article  Google Scholar 

  26. Verhulst SL, Van Hoeck K, Schrauwen N, et al. Sleep-disordered breathing and uric acid in overweight and obese children and adolescents. Chest. 2007;132:76–80.

    Article  PubMed  Google Scholar 

  27. Tauman R, O’Brien LM, Gozal D. Hypoxemia and obesity modulate plasma C-reactive protein and interleukin-6 levels in sleep-disordered breathing. Sleep Breath. 2007;11:77–84.

    Article  PubMed  Google Scholar 

  28. Larkin EK, Rosen CL, Kirchner HL, et al. Variation of C-reactive protein levels in adolescents: association with sleep-disordered breathing and sleep duration. Circulation. 2005;111:1978–84.

    Article  CAS  PubMed  Google Scholar 

  29. Bhattacharjee R, Kim J, Kheirandish-Gozal L, et al. Obesity and obstructive sleep apnea syndrome in children: a tale of inflammatory cascades. Pediatr Pulmonol. 2011;46:313–23.

    Article  PubMed  Google Scholar 

  30. Liao D, Li X, Rodriguez-Colon SM, et al. Sleep-disordered breathing and cardiac autonomic modulation in children. Sleep Med. 2010;11:484–8.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Aljadeff G, Gozal D, Schechtman VL, et al. Heart rate variability in children with obstructive sleep apnea. Sleep. 1997;20:151–7.

    Article  CAS  PubMed  Google Scholar 

  32. Bratel T, Wennlund A, Carlström K. Pituitary reactivity, androgens and catecholamines in obstructive sleep apnoea. Effects of continuous positive airway pressure treatment (CPAP). Respir Med. 1999;93:1–7.

    Article  CAS  PubMed  Google Scholar 

  33. Spiegel K, Knutson K, Leproult R, et al. Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes. J Appl Physiol (1985). 2005;99:2008–19.

    Article  CAS  Google Scholar 

  34. Flint J, Kothare SV, Zihlif M, et al. Association between inadequate sleep and insulin resistance in obese children. J Pediatr. 2007;150:364–9.

    Article  CAS  PubMed  Google Scholar 

  35. Verhulst SL, Schrauwen N, Haentjens D, et al. Sleep duration and metabolic dysregulation in overweight children and adolescents. Arch Dis Child. 2008;93:89–90.

    Article  CAS  PubMed  Google Scholar 

  36. Van Eyck A, Van Hoorenbeeck K, De Winter BY, et al. Sleep-disordered breathing and C-reactive protein in obese children and adolescents. Sleep Breath. 2014;18:335–40.

    PubMed  Google Scholar 

  37. Van Eyck A, Van Hoorenbeeck K, De Winter BY, et al. Sleep-disordered breathing, systemic adipokine secretion and metabolic dysregulation in overweight and obese children and adolescents. Sleep Med. 2017 Feb;30:52–6.

    Article  PubMed  Google Scholar 

  38. Beebe DW. Neurobehavioral morbidity associated with disordered breathing during sleep in children: a comprehensive review. Sleep. 2006;29:1115–34.

    Article  PubMed  Google Scholar 

  39. Verhulst SL, Schrauwen N, Haentjens D, et al. Sleep-disordered breathing and the metabolic syndrome in overweight and obese children and adolescents. J Pediatr. 2007;150:608–12.

    Article  CAS  PubMed  Google Scholar 

  40. Redline S, Storfer-Isser A, Rosen CL, et al. Association between metabolic syndrome and sleep-disordered breathing in adolescents. Am J Respir Crit Care Med. 2007;176:401–8.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Amin RS, Carroll JL, Jeffries JL, et al. Twenty-four-hour ambulatory blood pressure in children with sleep-disordered breathing. Am J Respir Crit Care Med. 2004;169:950–6.

    Article  PubMed  Google Scholar 

  42. Marcus CL, Greene MG, Carroll JL. Blood pressure in children with obstructive sleep apnea. Am J Respir Crit Care Med. 1998;157:1098–103.

    Article  CAS  PubMed  Google Scholar 

  43. Amin RS, Kimball TR, Bean JA, et al. Left ventricular hypertrophy and abnormal ventricular geometry in children and adolescents with obstructive sleep apnea. Am J Respir Crit Care Med. 2002;165:1395–9.

    Article  PubMed  Google Scholar 

  44. Amin RS, Kimball TR, Kalra M, et al. Left ventricular function in children with sleep-disordered breathing. Am J Cardiol. 2005;95:801–4.

    Article  PubMed  Google Scholar 

  45. Waters KA, Mast BT, Vella S, et al. Structural equation modeling of sleep apnea, inflammation, and metabolic dysfunction in children. J Sleep Res. 2007;16:388–95.

    Article  PubMed  Google Scholar 

  46. Dubern B, Tounian P, Medjadhi N, et al. Pulmonary function and sleep-related breathing disorders in severely obese children. Clin Nutr. 2006;25:803–9.

    Article  PubMed  Google Scholar 

  47. Tauman R, O’Brien LM, Ivanenko A, et al. Obesity rather than severity of sleep-disordered breathing as the major determinant of insulin resistance and altered lipidemia in snoring children. Pediatrics. 2005;116:e66–73.

    Article  PubMed  Google Scholar 

  48. Kaditis AG, Alexopoulos EI, Damani E, et al. Obstructive sleep-disordered breathing and fasting insulin levels in nonobese children. Pediatr Pulmonol. 2005;40:515–23.

    Article  PubMed  Google Scholar 

  49. Quante M, Wang R, Weng J, et al. The effect of adenotonsillectomy for childhood sleep apnea on cardiometabolic measures. Sleep. 2015;38:1395–403.

    PubMed  PubMed Central  Google Scholar 

  50. Waters KA, Sitha S, O'Brien LM, et al. Follow-up on metabolic markers in children treated for obstructive sleep apnea. Am J Respir Crit Care Med. 2006;174:455–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Gozal D, Capdevila OS, Kheirandish-Gozal L. Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal children. Am J Respir Crit Care Med. 2008;177:1142–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Apostolidou MT, Alexopoulos EI, Damani E, et al. Absence of blood pressure, metabolic, and inflammatory marker changes after adenotonsillectomy for sleep apnea in Greek children. Pediatr Pulmonol. 2008;43:550–60.

    Article  PubMed  Google Scholar 

  53. Costa DJ, Mitchell R. Adenotonsillectomy for obstructive sleep apnea in obese children: a meta-analysis. Otolaryngol Head Neck Surg. 2009;140:455–60.

    Article  PubMed  Google Scholar 

  54. Amin R, Anthony L, Somers V, et al. Growth velocity predicts recurrence of sleep-disordered breathing 1 year after adenotonsillectomy. Am J Respir Crit Care Med. 2008;177:654–9.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Kalra M, Inge T, Garcia V, et al. Obstructive sleep apnea in extremely overweight adolescents undergoing bariatric surgery. Obes Res. 2005;13:1175–9.

    Article  PubMed  Google Scholar 

  56. Alqahtani AR, Elahmedi MO, Al Qahtani A. Co-morbidity resolution in morbidly obese children and adolescents undergoing sleeve gastrectomy. Surg Obes Relat Dis. 2014;10:842–50.

    Article  PubMed  Google Scholar 

  57. Verhulst SL, Franckx H, Van Gaal L, et al. The effect of weight loss on sleep-disordered breathing in obese teenagers. Obesity (Silver Spring). 2009;17:1178–83.

    Google Scholar 

  58. Chen X, Beydoun MA, Wang Y. Is sleep duration associated with childhood obesity? A systematic review and meta-analysis. Obesity (Silver Spring). 2008;16:265–74.

    Article  Google Scholar 

  59. Fatima Y, Doi SA, Mamun AA. Longitudinal impact of sleep on overweight and obesity in children and adolescents: a systematic review and bias-adjusted meta-analysis. Obes Rev. 2015;16:137–49.

    Article  CAS  PubMed  Google Scholar 

  60. Wu Y, Gong Q, Zou Z, et al. Short sleep duration and obesity among children: a systematic review and meta-analysis of prospective studies. Obes Res Clin Pract. 2017;11(2):140–50.

    Article  PubMed  Google Scholar 

  61. Leproult R, Van Cauter E. Role of sleep and sleep loss in hormonal release and metabolism. Endocr Dev. 2010;17:11–21.

    Article  CAS  PubMed  Google Scholar 

  62. Briancon-Marjollet A, Weiszenstein M, Henri M, et al. The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms. Diabetol Metab Syndr. 2015;7:25.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Zimberg IZ, Damaso A, Del Re M, et al. Short sleep duration and obesity: mechanisms and future perspectives. Cell Biochem Funct. 2012;30:524–9.

    Article  CAS  PubMed  Google Scholar 

  64. Taheri S. The link between short sleep duration and obesity: we should recommend more sleep to prevent obesity. Arch Dis Child. 2006;91:881–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Stijn Verhulst MD, MSc, PhD .

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Van Eyck, A., Verhulst, S. (2018). Sleep-Disordered Breathing and Sleep Duration in Childhood Obesity. In: Freemark, M. (eds) Pediatric Obesity. Contemporary Endocrinology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-68192-4_28

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  • DOI: https://doi.org/10.1007/978-3-319-68192-4_28

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