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  • © 2017

Dermal Drug Selection and Development

An Industrial Perspective

  • The only book of its kind that describes how the industry develops and selects dermal drugs, complete with its challenges and opportunities

  • Discusses how the science can be used for increased success by clinicians when working with their patients and the abundance of new targets for dermatology

  • Covers the scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate

  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xv
  2. Introduction

    • Lionel Trottet, Howard Maibach
    Pages 1-13
  3. Choosing Topical Drug Candidate: Historical Overview

    • Lionel Trottet, Howard Maibach
    Pages 15-28
  4. Topical Versus Oral/Systemic Drug Discovery

    • Lionel Trottet, Howard Maibach
    Pages 39-48
  5. Assessing Drug Concentration in Skin: Direct and Indirect Methods

    • Lionel Trottet, Howard Maibach
    Pages 49-67
  6. Assessing Topical Efficacy

    • Lionel Trottet, Howard Maibach
    Pages 69-86
  7. Assessing Therapeutic Index

    • Lionel Trottet, Howard Maibach
    Pages 87-93
  8. Topical Vehicle Selection: Myths and Reality

    • Lionel Trottet, Howard Maibach
    Pages 95-107
  9. Dermal Drug Development Strategies

    • Lionel Trottet, Howard Maibach
    Pages 109-113
  10. Topical Drug Candidate Selection Criteria and Cascade

    • Lionel Trottet, Howard Maibach
    Pages 115-131
  11. Conclusions and Perspectives

    • Lionel Trottet, Howard Maibach
    Pages 139-143
  12. Back Matter

    Pages 145-148

About this book

The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field. Delivery of drugs through the skin has been an attractive and challenging area for research, and advances in modern technologies have resulted in a larger number of drugs being delivered transdermally, including conventional hydrophobic small molecule drugs, hydrophilic drugs and macromolecules. Offering the perspective from the industrial side of selection and development of drugs, the primary audience is geared towards the pharmaceutical industry but can also offer valuable information to clinicians, compounding pharmacists, and similarly pharmacy students. Dermal Drug Selection and Development covers the

scientific gaps that exist in terms of dermal pharmacokinetics and the resulting uncertainty by clinicians when choosing a drug candidate.

Reviews

“This book provides some valuable insights into the challenges related to the design and development of dermatopharmaceuticals. As such, this book is expected to be well received by the scientific community involved in this kind of research. … this book should serve as a reference for anyone interested in developing dermatopharmaceuticals. … Written by an expert in drug delivery, this book provides an overview of challenges the industry faces in selecting and developing a dermal product.” (Rahmat M. Talukder, Doody's Book Reviews, September, 2017)

Authors and Affiliations

  • Oncodesign, Centre de Recherches François Hyafil, Villebon sur Yvette, France

    Lionel Trottet

  • Dermatology Department, Medical School, University of California, San Francisco, USA

    Howard Maibach, MD

About the authors

Lionel Trottet, PhD is a DMPK Unit Manager, Drug Discovery chez Oncodesign in France. He has 20 years of expertise in Dermatology (dermal drug discovery, pharmacokinetics, PK/PD and formulation), 18 years of experience in general pharmacokinetics, drug metabolism and PK/PD, 13 years of experience as a DMPK representative in Drug Discovery projects, and 8 years of experience as a DMPK manager.

Howard Maibach, MD is an expert in contact and occupational dermatitis and sees patients at the Environmental Dermatosis Clinic, which is part of the Dermatology Clinic at University of California, San Francisco (UCSF). His specialty is dermatotoxicology, or skin exposure toxicity; allergies and skin disorders; and dermatopharmacology or the study of medications for skin disorders. Dr. Maibach has been on the editorial board of more than 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatolo
gical Society and the Internal Commission on Occupation Health. He is a professor in the Department of Dermatology at UCSF.

Bibliographic Information

  • Book Title: Dermal Drug Selection and Development

  • Book Subtitle: An Industrial Perspective

  • Authors: Lionel Trottet, Howard Maibach, MD

  • DOI: https://doi.org/10.1007/978-3-319-59504-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-59503-0Published: 16 August 2017

  • Softcover ISBN: 978-3-319-86639-0Published: 12 August 2018

  • eBook ISBN: 978-3-319-59504-7Published: 07 August 2017

  • Edition Number: 1

  • Number of Pages: XVI, 148

  • Number of Illustrations: 18 b/w illustrations, 35 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology, Dermatology

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access