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Store-Operated Ca²⁺ Entry (SOCE) Pathways pp 59–81Cite as

The STIM-Orai Pathway: The Interactions Between STIM and Orai

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 993))

Abstract

A primary Ca2+ entry pathway in non-excitable cells is established by the Ca2+ release-activated Ca2+ channels. Their two limiting molecular components include the Ca2+-sensor protein STIM1 located in the endoplasmic reticulum and the Orai channel in the plasma membrane. STIM1 senses the luminal Ca2+ content, and store depletion induces its oligomerization into puncta-like structures, thereby triggering coupling to as well as activation of Orai channels. A C-terminal STIM1 domain is assumed to couple to both C- and N-terminal, cytosolic strands of Orai, accomplishing gating of the channel. Here we highlight the inter- and intramolecular steps of the STIM1-Orai signaling cascade together with critical sites of the pore structure that accomplishes Ca2+ permeation.

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Acknowledgments

This work was supported by the Austrian Science Fund projects P28123 (to MF), P26067 (to RS), P28498 (to MM), P25210 as well as P27641 (to ID), and P27263 (to CR).

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Authors and Affiliations

  1. Institute of Biophysics, Johannes Kepler University Linz, 4020, Linz, Austria

    Marc Fahrner, Rainer Schindl, Martin Muik, Isabella Derler & Christoph Romanin

Authors
  1. Marc Fahrner
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  2. Rainer Schindl
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  3. Martin Muik
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  4. Isabella Derler
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  5. Christoph Romanin
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Correspondence to Marc Fahrner or Christoph Romanin .

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Editors and Affiliations

  1. Institute of Biophysics, Medical University of Graz, Graz, Austria

    Klaus Groschner

  2. Institute of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria

    Wolfgang F. Graier

  3. Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria

    Christoph Romanin

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Fahrner, M., Schindl, R., Muik, M., Derler, I., Romanin, C. (2017). The STIM-Orai Pathway: The Interactions Between STIM and Orai. In: Groschner, K., Graier, W., Romanin, C. (eds) Store-Operated Ca²⁺ Entry (SOCE) Pathways. Advances in Experimental Medicine and Biology, vol 993. Springer, Cham. https://doi.org/10.1007/978-3-319-57732-6_4

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