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Diagnosis and Classification of Proximal Junctional Kyphosis and Proximal Junctional Failure

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Abstract

Technical advancements have allowed the spinal deformity surgeon to achieve newfound abilities to correct severe spinal malalignment. However, proximal adjacent segment pathology (ASP) remains a significant issue. Examples include proximal junctional kyphosis (PJK) and proximal junctional failure (PJF). Agreement on the definition, classification, and pathophysiology of PJK and PJF remains elusive, and an understanding of the risk factors, means of prevention, and treatment of this problem remains to be elucidated. In general, PJK is a relatively asymptomatic radiographic diagnosis managed with patient reassurance and monitoring. On the other hand, PJF is a more serious entity on the ASP continuum. PJF is characterized by mechanical instability, pain, and more severe kyphosis, with potential for neurologic compromise. Patients who develop PJF more often require revision surgery than those with PJK. This chapter will review the current understanding of PJK and PJF.

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References

  1. Bastian L, Lange U, Knop C, Tusch G, Blauth M. Evaluation of the mobility of adjacent segments after posterior thoracolumbar fixation: a biomechanical study. Eur Spine J. 2001;10(4):295–300.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Chow DH, Luk KD, Evans JH, Leong JC. Effects of short anterior lumbar interbody fusion on biomechanics of neighboring unfused segments. Spine. 1996;21(5):549–55.

    Article  CAS  PubMed  Google Scholar 

  3. Ha KY, Schendel MJ, Lewis JL, Ogilvie JW. Effect of immobilization and configuration on lumbar adjacent-segment biomechanics. J Spinal Disord. 1993;6(2):99–105.

    Article  CAS  PubMed  Google Scholar 

  4. Lee CK, Langrana NA. Lumbosacral spinal fusion. A biomechanical study. Spine. 1984;9(6):574–81.

    Article  CAS  PubMed  Google Scholar 

  5. Park P, Garton HJ, Gala VC, Hoff JT, McGillicuddy JE. Adjacent segment disease after lumbar or lumbosacral fusion: review of the literature. Spine. 2004;29(17):1938–44.

    Article  PubMed  Google Scholar 

  6. Shono Y, Kaneda K, Abumi K, McAfee PC, Cunningham BW. Stability of posterior spinal instrumentation and its effects on adjacent motion segments in the lumbosacral spine. Spine. 1998;23(14):1550–8.

    Article  CAS  PubMed  Google Scholar 

  7. Untch C, Liu Q, Hart R. Segmental motion adjacent to an instrumented lumbar fusion: the effect of extension of fusion to the sacrum. Spine. 2004;29(21):2376–81.

    Article  PubMed  Google Scholar 

  8. Yang SW, Langrana NA, Lee CK. Biomechanics of lumbosacral spinal fusion in combined compression-torsion loads. Spine. 1986;11(9):937–41.

    Article  CAS  PubMed  Google Scholar 

  9. Yoganandan N, Pintar F, Maiman DJ, Reinartz J, Sances Jr A, Larson SJ, Cusick JF. Kinematics of the lumbar spine following pedicle screw plate fixation. Spine. 1993;18(4):504–12.

    Article  CAS  PubMed  Google Scholar 

  10. Javedan SP, Dickman CA. Cause of adjacent-segment disease after spinal fusion. Lancet. 1999;354(9178):530–1.

    Article  CAS  PubMed  Google Scholar 

  11. Kasliwal MK, Shaffrey CI, Lenke LG, Dettori JR, Ely CG, Smith JS. Frequency, risk factors, and treatment of distal adjacent segment pathology after long thoracolumbar fusion: a systematic review. Spine. 2012;37(22 Suppl):S165–79.

    Article  PubMed  Google Scholar 

  12. Kraemer P, Fehlings MG, Hashimoto R, Lee MJ, Anderson PA, Chapman JR, Raich A, Norvell DC. A systematic review of definitions and classification systems of adjacent segment pathology. Spine. 2012;37(22 Suppl):S31–9.

    Article  PubMed  Google Scholar 

  13. Aota Y, Kumano K, Hirabayashi S. Postfusion instability at the adjacent segments after rigid pedicle screw fixation for degenerative lumbar spinal disorders. J Spinal Disord. 1995;8(6):464–73.

    Article  CAS  PubMed  Google Scholar 

  14. DeWald CJ, Stanley T. Instrumentation-related complications of multilevel fusions for adult spinal deformity patients over age 65: surgical considerations and treatment options in patients with poor bone quality. Spine. 2006;31(19 Suppl):S144–51.

    Article  PubMed  Google Scholar 

  15. Etebar S, Cahill DW. Risk factors for adjacent-segment failure following lumbar fixation with rigid instrumentation for degenerative instability. J Neurosurg. 1999;90(2 Suppl):163–9.

    CAS  PubMed  Google Scholar 

  16. Glattes RC, Bridwell KH, Lenke LG, Kim YJ, Rinella A, Edwards 2nd C. Proximal junctional kyphosis in adult spinal deformity following long instrumented posterior spinal fusion: incidence, outcomes, and risk factor analysis. Spine. 2005;30(14):1643–9.

    Article  PubMed  Google Scholar 

  17. Hambly MF, Wiltse LL, Raghavan N, Schneiderman G, Koenig C. The transition zone above a lumbosacral fusion. Spine. 1998;23(16):1785–92.

    Article  CAS  PubMed  Google Scholar 

  18. Hart RA, Prendergast MA, Roberts WG, Nesbit GM, Barnwell SL. Proximal junctional acute collapse cranial to multi-level lumbar fusion: a cost analysis of prophylactic vertebral augmentation. Spine J. 2008;8(6):875–81.

    Article  PubMed  Google Scholar 

  19. Kim YJ, Bridwell KH, Lenke LG, Glattes CR, Rhim S, Cheh G. Proximal junctional kyphosis in adult spinal deformity after segmental posterior spinal instrumentation and fusion: minimum five-year follow-up. Spine. 2008;33(20):2179–84.

    Article  PubMed  Google Scholar 

  20. Kim YJ, Bridwell KH, Lenke LG, Rhim S, Cheh G. Sagittal thoracic decompensation following long adult lumbar spinal instrumentation and fusion to L5 or S1: causes, prevalence, and risk factor analysis. Spine. 2006;31(20):2359–66.

    Article  PubMed  Google Scholar 

  21. Lee CK. Accelerated degeneration of the segment adjacent to a lumbar fusion. Spine. 1988;13(3):375–7.

    Article  CAS  PubMed  Google Scholar 

  22. O'Leary PT, Bridwell KH, Lenke LG, Good CR, Pichelmann MA, Buchowski JM, Kim YJ, Flynn J. Risk factors and outcomes for catastrophic failures at the top of long pedicle screw constructs: a matched cohort analysis performed at a single center. Spine. 2009;34(20):2134–9.

    Article  PubMed  Google Scholar 

  23. Schlegel JD, Smith JA, Schleusener RL. Lumbar motion segment pathology adjacent to thoracolumbar, lumbar, and lumbosacral fusions. Spine. 1996;21(8):970–81.

    Article  CAS  PubMed  Google Scholar 

  24. Watanabe K, Lenke LG, Bridwell KH, Kim YJ, Koester L, Hensley M. Proximal junctional vertebral fracture in adults after spinal deformity surgery using pedicle screw constructs: analysis of morphological features. Spine. 2010;35(2):138–45.

    Article  PubMed  Google Scholar 

  25. Cho SK, Shin JI, Kim YJ. Proximal junctional kyphosis following adult spinal deformity surgery. Eur Spine J. 2014;23(12):2726–36.

    Article  PubMed  Google Scholar 

  26. Denis F, Sun EC, Winter RB. Incidence and risk factors for proximal and distal junctional kyphosis following surgical treatment for Scheuermann kyphosis: minimum five-year follow-up. Spine. 2009;34(20):E729–34.

    Article  PubMed  Google Scholar 

  27. Hart R, McCarthy I, O'Brien M, Bess S, Line B, Adjei OB, Burton D, Gupta M, Ames C, Deviren V, Kebaish K, Shaffrey C, Wood K, Hostin R. International Spine Study G. Identification of decision criteria for revision surgery among patients with proximal junctional failure after surgical treatment of spinal deformity. Spine. 2013;38(19):E1223–7.

    Article  PubMed  Google Scholar 

  28. Hart RA, McCarthy I, Ames CP, Shaffrey CI, Hamilton DK, Hostin R. Proximal junctional kyphosis and proximal junctional failure. Neurosurg Clin N Am. 2013;24(2):213–8.

    Article  PubMed  Google Scholar 

  29. Hostin R, McCarthy I, O'Brien M, Bess S, Line B, Boachie-Adjei O, Burton D, Gupta M, Ames C, Deviren V, Kebaish K, Shaffrey C, Wood K, Hart R, International Spine Study G. Incidence, mode, and location of acute proximal junctional failures after surgical treatment of adult spinal deformity. Spine. 2013;38(12):1008–15.

    Article  PubMed  Google Scholar 

  30. Smith MW, Annis P, Lawrence BD, Daubs MD, Brodke DS. Acute proximal junctional failure in patients with preoperative sagittal imbalance. Spine J. 2015;15(10):2142–8.

    Article  PubMed  Google Scholar 

  31. Simmons ED, Huckell CB, Zheng Y. Proximal kyphosis “topping off syndrome” and retrolisthesis secondary to multilevel lumbar fusion in the elderly patients. Spine J. 4(5):S114.

    Google Scholar 

  32. Toyone T, Ozawa T, Kamikawa K, Watanabe A, Matsuki K, Yamashita T, Shiboi R, Takeuchi M, Wada Y, Inada K, Aoki Y, Inoue G, Ohtori S, Tanaka T. Subsequent vertebral fractures following spinal fusion surgery for degenerative lumbar disease: a mean ten-year follow-up. Spine. 2010;35(21):1915–8.

    Article  PubMed  Google Scholar 

  33. Bridwell KH, Lenke LG, Cho SK, Pahys JM, Zebala LP, Dorward IG, Cho W, Baldus C, Hill BW, Kang MM. Proximal junctional kyphosis in primary adult deformity surgery: evaluation of 20 degrees as a critical angle. Neurosurgery. 2013;72(6):899–906.

    Article  PubMed  Google Scholar 

  34. O’Shaughnessy BA, Bridwell KH, Lenke LG, Cho W, Baldus C, Chang MS, Auerbach JD, Crawford CH. Does a long-fusion “T3-sacrum” portend a worse outcome than a short-fusion “T10-sacrum” in primary surgery for adult scoliosis? Spine. 2012;37(10):884–90.

    Article  PubMed  Google Scholar 

  35. Helgeson MD, Shah SA, Newton PO, Clements 3rd DH, Betz RR, Marks MC, Bastrom T, Harms Study G. Evaluation of proximal junctional kyphosis in adolescent idiopathic scoliosis following pedicle screw, hook, or hybrid instrumentation. Spine. 2010;35(2):177–81.

    Article  PubMed  Google Scholar 

  36. Sacramento-Dominguez C, Vayas-Diez R, Coll-Mesa L, Parrilla AP, Machado-Calvo M, Pinilla JA, Sosa AJ, Lopez GL. Reproducibility measuring the angle of proximal junctional kyphosis using the first or the second vertebra above the upper instrumented vertebrae in patients surgically treated for scoliosis. Spine. 2009;34(25):2787–91.

    Article  PubMed  Google Scholar 

  37. Yagi M, Rahm M, Gaines R, Maziad A, Ross T, Kim HJ, Kebaish K, Boachie-Adjei O, Complex Spine Study G. Characterization and surgical outcomes of proximal junctional failure in surgically treated patients with adult spinal deformity. Spine. 2014;39(10):E607–14.

    Article  PubMed  Google Scholar 

  38. Hyun SJ, Rhim SC. Clinical outcomes and complications after pedicle subtraction osteotomy for fixed sagittal imbalance patients: a long-term follow-up data. J Korean Neurosurg Soc. 2010;47(2):95–101.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Kim HJ, Lenke LG, Shaffrey CI, Van Alstyne EM, Skelly AC. Proximal junctional kyphosis as a distinct form of adjacent segment pathology after spinal deformity surgery: a systematic review. Spine. 2012;37(22 Suppl):S144–64.

    Article  PubMed  Google Scholar 

  40. Mendoza-Lattes S, Ries Z, Gao Y, Weinstein SL. Proximal junctional kyphosis in adult reconstructive spine surgery results from incomplete restoration of the lumbar lordosis relative to the magnitude of the thoracic kyphosis. The Iowa Orthop J. 2011;31:199–206.

    PubMed  Google Scholar 

  41. Yagi M, Akilah KB, Boachie-Adjei O. Incidence, risk factors and classification of proximal junctional kyphosis: surgical outcomes review of adult idiopathic scoliosis. Spine. 2011;36(1):E60–8.

    Article  PubMed  Google Scholar 

  42. Kim HJ, Bridwell KH, Lenke LG, Park MS, Ahmad A, Song KS, Piyaskulkaew C, Hershman S, Fogelson J, Mesfin A. Proximal junctional kyphosis results in inferior SRS pain subscores in adult deformity patients. Spine. 2013;38(11):896–901.

    Article  PubMed  Google Scholar 

  43. Yagi M, King AB, Boachie-Adjei O. Incidence, risk factors, and natural course of proximal junctional kyphosis: surgical outcomes review of adult idiopathic scoliosis. Minimum 5 years of follow-up. Spine. 2012;37(17):1479–89.

    Article  PubMed  Google Scholar 

  44. Kim YJ, Bridwell KH, Lenke LG, Kim J, Cho SK. Proximal junctional kyphosis in adolescent idiopathic scoliosis following segmental posterior spinal instrumentation and fusion: minimum 5-year follow-up. Spine. 2005;30(18):2045–50.

    Article  PubMed  Google Scholar 

  45. Kim YJ, Lenke LG, Bridwell KH, Kim J, Cho SK, Cheh G, Yoon J. Proximal junctional kyphosis in adolescent idiopathic scoliosis after 3 different types of posterior segmental spinal instrumentation and fusions: incidence and risk factor analysis of 410 cases. Spine. 2007;32(24):2731–8.

    Article  PubMed  Google Scholar 

  46. Wang J, Zhao Y, Shen B, Wang C, Li M. Risk factor analysis of proximal junctional kyphosis after posterior fusion in patients with idiopathic scoliosis. Injury. 2010;41(4):415–20.

    Article  PubMed  Google Scholar 

  47. Kim HJ, Bridwell KH, Lenke LG, Park MS, Song KS, Piyaskulkaew C, Chuntarapas T. Patients with proximal junctional kyphosis requiring revision surgery have higher postoperative lumbar lordosis and larger sagittal balance corrections. Spine. 2014;39(9):E576–80.

    Article  PubMed  Google Scholar 

  48. Lonner BS, Newton P, Betz R, Scharf C, O'Brien M, Sponseller P, Lenke L, Crawford A, Lowe T, Letko L, Harms J, Shufflebarger H. Operative management of Scheuermann's kyphosis in 78 patients: radiographic outcomes, complications, and technique. Spine. 2007;32(24):2644–52.

    Article  PubMed  Google Scholar 

  49. Lowe TG, Kasten MD. An analysis of sagittal curves and balance after Cotrel-Dubousset instrumentation for kyphosis secondary to Scheuermann’s disease. A review of 32 patients. Spine. 1994;19(15):1680–5.

    Article  CAS  PubMed  Google Scholar 

  50. Maruo K, Ha Y, Inoue S, Samuel S, Okada E, Hu SS, Deviren V, Burch S, William S, Ames CP, Mummaneni PV, Chou D, Berven SH. Predictive factors for proximal junctional kyphosis in long fusions to the sacrum in adult spinal deformity. Spine. 2013;38(23):E1469–76.

    Article  PubMed  Google Scholar 

  51. Cammarata M, Aubin CE, Wang X, Mac-Thiong JM. Biomechanical risk factors for proximal junctional kyphosis: a detailed numerical analysis of surgical instrumentation variables. Spine. 2014;39(8):E500–7.

    Article  PubMed  Google Scholar 

  52. Kim HJ, Yagi M, Nyugen J, Cunningham ME, Boachie-Adjei O. Combined anterior-posterior surgery is the most important risk factor for developing proximal junctional kyphosis in idiopathic scoliosis. Clin Orthop Relat Res. 2012;470(6):1633–9.

    Article  PubMed  Google Scholar 

  53. Bjerke-Kroll B, Saiyed R, Cheung Z, Shifflett G, Sheha E, Cunningam M. Postsurgical predictors of proximal junctional kyphosis in adolescent idiopathic scoliosis. Spine J. 2015;15(10):S148.

    Article  Google Scholar 

  54. Blondel B, Schwab F, Ungar B, Smith J, Bridwell K, Glassman S, Shaffrey C, Farcy JP, Lafage V. Impact of magnitude and percentage of global sagittal plane correction on health-related quality of life at 2-years follow-up. Neurosurgery. 2012;71(2):341–8. ; discussion 8.

    Article  PubMed  Google Scholar 

  55. Lee GA, Betz RR, Clements 3rd DH, Huss GK. Proximal kyphosis after posterior spinal fusion in patients with idiopathic scoliosis. Spine. 1999;24(8):795–9.

    Article  CAS  PubMed  Google Scholar 

  56. Arlet V, Aebi M. Junctional spinal disorders in operated adult spinal deformities: present understanding and future perspectives. Eur Spine J. 2013;22(Suppl 2):S276–95.

    Article  PubMed  Google Scholar 

  57. Hollenbeck SM, Glattes RC, Asher MA, Lai SM, Burton DC. The prevalence of increased proximal junctional flexion following posterior instrumentation and arthrodesis for adolescent idiopathic scoliosis. Spine. 2008;33(15):1675–81.

    Article  PubMed  Google Scholar 

  58. Rhee JM, Bridwell KH, Won DS, Lenke LG, Chotigavanichaya C, Hanson DS. Sagittal plane analysis of adolescent idiopathic scoliosis: the effect of anterior versus posterior instrumentation. Spine. 2002;27(21):2350–6.

    Article  PubMed  Google Scholar 

  59. Ha Y, Maruo K, Racine L, Schairer WW, Hu SS, Deviren V, Burch S, Tay B, Chou D, Mummaneni PV, Ames CP, Berven SH. Proximal junctional kyphosis and clinical outcomes in adult spinal deformity surgery with fusion from the thoracic spine to the sacrum: a comparison of proximal and distal upper instrumented vertebrae. J Neurosurg Spine. 2013;19(3):360–9.

    Article  PubMed  Google Scholar 

  60. Lau D, Clark AJ, Scheer JK, Daubs MD, Coe JD, Paonessa KJ, LaGrone MO, Kasten MD, Amaral RA, Trobisch PD, Lee JH, Fabris-Monterumici D, Anand N, Cree AK, Hart RA, Hey LA, Ames CP, Committee SRSASD. Proximal junctional kyphosis and failure after spinal deformity surgery: a systematic review of the literature as a background to classification development. Spine. 2014;39(25):2093–102.

    Article  PubMed  Google Scholar 

  61. Lau D, Funao H, Clark AJ, Nicholls F, Smith J, Bess S, Shaffrey C, Schwab FJ, Lafage V, Deviren V, Hart R, Kebaish KM, Ames CP, International Spine Study G. The clinical correlation of the hart-ISSG proximal junctional kyphosis severity scale with health-related quality-of-life outcomes and need for revision surgery. Spine. 2016;41(3):213–23.

    Article  PubMed  Google Scholar 

  62. Rastegar F, Contag A, Daniels A, Hiratzka J, Lin C, Chang J, Than K, Raslan A, Kong C, Nguyen N, Hostin R, Hart R. Proximal junctional kyphosis: inter- and intra-observer reliability in adult spinal deformity. Presented at the Lumbar Spine Research Society, Chicago, IL April 14–15, 2016.

    Google Scholar 

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Nguyen, NL.M., Kong, C.Y., Kebaish, K.M., Safaee, M.M., Ames, C.P., Hart, R.A. (2017). Diagnosis and Classification of Proximal Junctional Kyphosis and Proximal Junctional Failure. In: Klineberg, E. (eds) Adult Lumbar Scoliosis. Springer, Cham. https://doi.org/10.1007/978-3-319-47709-1_17

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