Abstract
HIV-1 reverse transcriptase (RT) is essential for viral replication and is a major target for antiretroviral therapy. There are 26 FDA-approved drugs for the treatment of HIV, 12 are designed to target RT and some are the most widely prescribed agents especially as fixed-dose combinations. By inhibiting the enzyme required for copying the viral genome, viral replication can be stopped. RT is responsible for synthesizing double-stranded DNA from the viral single-stranded RNA genome during the process of reverse transcription. It is a DNA polymerase that can use RNA or DNA as a template and it also has RNase H activity, which cleaves RNA annealed to DNA [1–3].
Keywords
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This work was supported in part by NIH grant 1RO1MH100999-01 and 5P30-AI-50409 (CFAR).
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Herman, B.D., Domaoal, R.A., Ehteshami, M., Schinazi, R.F. (2017). Resistance Mechanisms to HIV-1 Nucleoside Reverse Transcriptase Inhibitors. In: Mayers, D., Sobel, J., Ouellette, M., Kaye, K., Marchaim, D. (eds) Antimicrobial Drug Resistance. Springer, Cham. https://doi.org/10.1007/978-3-319-46718-4_33
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