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Heart Development, Angiogenesis, and Blood-Brain Barrier Function Is Modulated by Adhesion GPCRs

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Book cover Adhesion G Protein-coupled Receptors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 234))

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Abstract

The cardiovascular system in adult organisms forms a network of interconnected endothelial cells, supported by mural cells and displaying a high degree of hierarchy: arteries emerging from the heart ramify into arterioles and then capillaries, which return to the venous systems through venules and veins. The cardiovascular system allows blood circulation, which in turn is essential for hemostasis through gas diffusion, nutrient distribution, and cell trafficking. In this chapter, we have summarized the current knowledge on how adhesion GPCRs (aGPCRs) impact heart development, followed by their role in modulating vascular angiogenesis.

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Acknowledgments

F.B.E. acknowledges support from the Deutsche Forschungsgemeinschaft (FOR2149, Project 7, EN 453/10-1). C.N.’s work in the Betsholtz lab was supported by grants from the European Research Council (ERC-AdG #294556 BBBARRIER), the European Union (ITN-2012-317250-VESSEL), the Swedish Cancer Foundation and the Swedish Research Council, the Knut and Alice Wallenberg Foundation, and the Leducq Foundation through the Sphingonet transatlantic network. Bioinformatics analyses were kindly communicated by Dr. Liqun He.

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Authors and Affiliations

  1. Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schwabachanlage 12, Erlangen, 91054, Germany

    Gentian Musa & Felix B. Engel

  2. Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, Uppsala, 751 85, Sweden

    Colin Niaudet

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  1. Gentian Musa
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  2. Felix B. Engel
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Correspondence to Felix B. Engel or Colin Niaudet .

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  1. Institute of Physiology Department of Neurophysiology, University of Würzburg, Würzburg, Germany

    Tobias Langenhan

  2. Institute of Biochemistry Medical Faculty, University of Leipzig, Leipzig, Germany

    Torsten Schöneberg

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Musa, G., Engel, F.B., Niaudet, C. (2016). Heart Development, Angiogenesis, and Blood-Brain Barrier Function Is Modulated by Adhesion GPCRs. In: Langenhan, T., Schöneberg, T. (eds) Adhesion G Protein-coupled Receptors. Handbook of Experimental Pharmacology, vol 234. Springer, Cham. https://doi.org/10.1007/978-3-319-41523-9_16

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