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Plasma Cell Dyscrasias

  • Book
  • © 2016

Overview

Editors:
  1. Aldo M. Roccaro

    1. Dept. of Medical Oncolgy/Hematology,, ASST-Spedali Civili di Brescia Dept. of Medical Oncolgy/Hematology,, Brescia, Italy

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  2. Irene M. Ghobrial

    1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA

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  • Documents the state of the art in the biology and treatment of plasma cell malignancies
  • Discusses advances in understanding of the responsible molecular mechanisms
  • Written by leading experts in the field
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Treatment and Research (CTAR, volume 169)

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About this book

This book provides a concise overview of the state of the art in the biology and treatment of plasma cell malignancies, a heterogeneous group of diseases primarily characterized by the presence of clonal plasma cells within the bone marrow or extramedullary sites. The plasma cell dyscrasias investigated include monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma, plasmacytoma, immunoglobulin deposition diseases (primary amyloidosis and systemic light and heavy chain deposition diseases), and Waldenström’s macroglobulinemia. In the case of multiple myeloma, the coverage ranges from genomic aberrations and microRNAs to treatment for different patient groups, upcoming novel therapies, immunotherapy, and transplantation. The book reflects the significant research advances achieved in this field during the past few years, which have enhanced our understanding of the molecular mechanisms responsible for the pathogenesis of plasma cell dyscrasias.

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-vi
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  2. Monoclonal Gammopathy of Undetermined Significance and Smoldering Myeloma

    1. Front Matter

      Pages 1-1
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    2. MGUS and Smoldering Multiple Myeloma: Diagnosis and Epidemiology

      • María-Victoria Mateos, Ola Landgren
      Pages 3-12

  3. Multiple Myeloma

    1. Front Matter

      Pages 13-13
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    2. Vision Statement for Multiple Myeloma: Future Directions

      • Kenneth C. Anderson
      Pages 15-22

    3. Genomic Aberrations in Multiple Myeloma

      • Salomon Manier, Karma Salem, Siobhan V. Glavey, Aldo M. Roccaro, Irene M. Ghobrial
      Pages 23-34

    4. Epigenetics in Multiple Myeloma

      • Siobhan V. Glavey, Salomon Manier, Antonio Sacco, Karma Salem, Yawara Kawano, Juliette Bouyssou et al.
      Pages 35-49

    5. Role of Endothelial Cells and Fibroblasts in Multiple Myeloma Angiogenic Switch

      • Domenico Ribatti, Angelo Vacca
      Pages 51-61

    6. Targeting the Bone Marrow Microenvironment

      • Michele Moschetta, Yawara Kawano, Klaus Podar
      Pages 63-102

    7. Multiple Myeloma Minimal Residual Disease

      • Bruno Paiva, Ramón García-Sanz, Jesús F. San Miguel
      Pages 103-122

    8. Treatment of Newly Diagnosed Elderly Multiple Myeloma

      • Guillemette Fouquet, Francesca Gay, Eileen Boyle, Sara Bringhen, Alessandra Larocca, Thierry Facon et al.
      Pages 123-143

    9. Management of Transplant-Eligible Patients with Newly Diagnosed Multiple Myeloma

      • Jacob Laubach, Shaji Kumar
      Pages 145-167

    10. Treatment of Relapsed/Refractory Multiple Myeloma

      • Paola Neri, Nizar J. Bahlis, Claudia Paba-Prada, Paul Richardson
      Pages 169-194

    11. Treatment of MM: Upcoming Novel Therapies

      • Sagar Lonial
      Pages 195-205

    12. Role of the Immune Response in Disease Progression and Therapy in Multiple Myeloma

      • Susan J. Lee, Ivan Borrello
      Pages 207-225

    13. Transplantation for Multiple Myeloma

      • Yogesh S. Jethava, Frits van Rhee
      Pages 227-250

    14. Bone Disease in Multiple Myeloma

      • Homare Eda, Loredana Santo, G. David Roodman, Noopur Raje
      Pages 251-270

  4. Primary Amyloidosis, Systemic Light Chain and Heavy Chain Diseases, Plasmacytoma

    1. Front Matter

      Pages 271-271
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    2. Immunoglobulin Light Chain Systemic Amyloidosis

      • Angela Dispenzieri, Giampaolo Merlini
      Pages 273-318

  5. Waldenstrom’s Macroglobulinemia

    1. Front Matter

      Pages 319-319
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Editors and Affiliations

  • Dept. of Medical Oncolgy/Hematology,, ASST-Spedali Civili di Brescia Dept. of Medical Oncolgy/Hematology,, Brescia, Italy

    Aldo M. Roccaro

  • Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA

    Irene M. Ghobrial

Bibliographic Information

  • Book Title: Plasma Cell Dyscrasias

  • Editors: Aldo M. Roccaro, Irene M. Ghobrial

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-3-319-40320-5

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-40318-2Published: 11 October 2016

  • Softcover ISBN: 978-3-319-82078-1Published: 16 June 2018

  • eBook ISBN: 978-3-319-40320-5Published: 01 October 2016

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: VI, 361

  • Number of Illustrations: 2 b/w illustrations, 7 illustrations in colour

  • Topics: Hematology, Oncology, Molecular Medicine

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