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Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature Infants

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Oxygen Transport to Tissue XXXVIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 923))

Abstract

Brain function is supported by an appropriate balance between the metabolic demand and the supply of nutrients and oxygen. However, the physiological principles behind the regulation of brain metabolism and demand in premature infants are unknown. Some studies found that changes in hemodynamic variables in this population precede changes in EEG activity; however, these studies only used descriptive statistics. This paper describes the relationship between changes in cerebral oxygenation, assessed by means of near-infrared spectroscopy (NIRS), and changes in EEG, using mathematical methods taken from information dynamics. In a cohort of 35 neonates subjected to sedation by propofol, we quantified the direction of information transfer between brain oxygenation and EEG. The results obtained indicate that, as reported in other studies, changes in NIRS are likely to precede changes in EEG activity.

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Acknowledgments

Alexander Caicedo is a postdoctoral fellow of the research foundation Flanders (FWO). Bijzonder Onderzoeksfonds KU Leuven (BOF). This research was also supported by: Center of Excellence (CoE) #: PFV/10/002 (OPTEC). Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (FWO), project #: G.0427.10N (Integrated EEG-fMRI), G.0108.11 (Compressed Sensing), G.0869.12N (Tumor imaging), G.0A5513N (Deep brain stimulation). Agentschap voor Innovatie door Wetenschap en Technologie (IWT), project #: TBM 080658-MRI (EEG-fMRI), TBM 110697-NeoGuard. iMinds Medical Information Technologies.. Dotatie-Strategisch basis onderzoek (SBO- 2015). ICON: NXT_Sleep. Belgian Federal Science Policy Office. IUAP #P7/19/ (DYSCO, ‘Dynamical systems, control and optimization’, 2012–2017). Belgian Foreign Affairs-Development Cooperation. VLIR UOS programs (2013–2019). EU: European Union’s Seventh Framework Programme (FP7/2007–2013): EU MC ITN TRANSACT 2012, #316679, ERASMUS EQR: Community service engineer, #539642-LLP-1-2013. Other EU: INTERREG IVB NWE programme #RECAP 209G. European Research Council: ERC Advanced Grant, #339804 BIOTENSORS. This paper reflects only the authors’ views and the Union is not liable for any use that may be made of the contained information.

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Authors and Affiliations

  1. Department of Electrical Engineering (ESAT), STADIUS, KU Leuven, Leuven, Belgium

    Alexander Caicedo & Sabine Van Huffel

  2. iMinds, Medical IT, Leuven, Belgium

    Alexander Caicedo & Sabine Van Huffel

  3. Department of Development and Regeneration, KU Leuven, Leuven, Belgium

    Liesbeth Thewissen, Gunnar Naulaers & Karel Allegaert

  4. Department of Neonatology, University Hospitals Leuven, Leuven, Belgium

    Liesbeth Thewissen, Gunnar Naulaers & Karel Allegaert

  5. Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium

    Anne Smits

Authors
  1. Alexander Caicedo
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  2. Liesbeth Thewissen
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  3. Anne Smits
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  4. Gunnar Naulaers
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  5. Karel Allegaert
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  6. Sabine Van Huffel
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Corresponding author

Correspondence to Alexander Caicedo .

Editor information

Editors and Affiliations

  1. Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

    Qingming Luo

  2. Molecular Imaging Laboratory, Department of Radiology, Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Lin Z. Li

  3. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

  4. Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

    Hua Shi

  5. ISOTT Historian, Ellicott City, Maryland, USA

    Duane F. Bruley

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© 2016 Springer International Publishing Switzerland

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Caicedo, A., Thewissen, L., Smits, A., Naulaers, G., Allegaert, K., Van Huffel, S. (2016). Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature Infants. In: Luo, Q., Li, L., Harrison, D., Shi, H., Bruley, D. (eds) Oxygen Transport to Tissue XXXVIII. Advances in Experimental Medicine and Biology, vol 923. Springer, Cham. https://doi.org/10.1007/978-3-319-38810-6_19

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