Abstract
Cartilage, at all sites of our body, has limited intrinsic capacity to repair. There are numerous methods to use when repairing cartilage, and the preferred method depends on the location of the cartilage defect, whether it is the nose, the ear, the airway, or a certain site in the joint. Different cell types with chondrogenic capacities are being used for cartilage regeneration. In this chapter we discuss the expansion in culture, the chondrogenic capacity, and the (clinical) application of articular chondrocytes, nasal chondrocytes, auricular chondrocytes, chondrocyte cell lines, mesenchymal stem cells, and pluripotent stem cells.
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Acknowledgments
Andrea Barbero is supported by the Swiss National Science Foundation (SNSF Project No. 310030_149614) and the Deutsche Arthrose-Hilfe (P245-A546-Martin-EP1-mumm1-knie-op-III-2011-15).
Diego Correa is in gratitude with the Case Center for Multimodal Evaluation of Engineered Cartilage (CCMEEC) through the NIH grant P41-EB021911, the Soffer Family Foundation, and the Diabetes Research Institute Foundation (DRIF).
Tim Hardingham in the Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, acknowledges support from the Wellcome Trust (grant number 088785/Z/09/Z).
Roberto Narcisi is supported by a VENI grant by STW (nr. 13659).
Mark Randolph would like to acknowledge Irina Pomerantseva, M.D., Ph.D., and Cathryn A. Sundback, Sc.D., from the Laboratory for Tissue Engineering and Organ Fabrication, Massachusetts General Hospital, for their contributions on the biology of auricular chondrocytes for generating ear cartilage.
Sandra van den Bosch is acknowledged for help with editing of the references.
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van Osch, G.J. et al. (2018). Cells for Cartilage Regeneration. In: Gimble, J., Marolt, D., Oreffo, R., Redl, H., Wolbank, S. (eds) Cell Engineering and Regeneration. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-319-37076-7_1-1
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DOI: https://doi.org/10.1007/978-3-319-37076-7_1-1
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