Skip to main content

Stem Cells in Rotator Cuff Healing

  • Chapter
  • First Online:
Rotator Cuff Tear

Abstract

Rotator cuff (RC) tears represent the vast majority of shoulder injuries in adult patients and are a common contributing factor to shoulder pain and occupational disability, and their prevalence in the population is rising. Although surgical procedures to repair have evolved and improved over the past decades, a high rate of failure, which may require additional therapy or re-intervention, thus decreasing the patient’s quality of life, has been observed after RC repair.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Deans RJ, Moseley AB (2000) Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol 28:875–884

    Article  CAS  PubMed  Google Scholar 

  2. Pittenger MF et al (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143–147

    Article  CAS  PubMed  Google Scholar 

  3. Mazzocca AD et al (2010) Rapid isolation of human stem cells (connective tissue progenitor cells) from the proximal humerus during arthroscopic rotator cuff surgery. Am J Sports Med 38:1438–1447. doi:10.1177/0363546509360924

    Article  PubMed  Google Scholar 

  4. Mazzocca AD et al (2011) Bone marrow-derived mesenchymal stem cells obtained during arthroscopic rotator cuff repair surgery show potential for tendon cell differentiation after treatment with insulin. Arthroscopy 27:1459–1471. doi:10.1016/j.arthro.2011.06.029

    Article  PubMed  Google Scholar 

  5. Beitzel K et al (2013) Comparison of mesenchymal stem cells (osteoprogenitors) harvested from proximal humerus and distal femur during arthroscopic surgery. Arthroscopy 29:301–308. doi:10.1016/j.arthro.2012.08.021

    Article  PubMed  Google Scholar 

  6. Izadpanah R et al (2006) Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem 99:1285–1297. doi:10.1002/jcb.20904

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Bi Y et al (2007) Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med 13:1219–1227. doi:10.1038/nm1630

    Article  CAS  PubMed  Google Scholar 

  8. Tsai CC, Huang TF, Ma HL, Chiang ER, Hung SC (2013) Isolation of mesenchymal stem cells from shoulder rotator cuff: a potential source for muscle and tendon repair. Cell Transplant 22:413–422. doi:10.3727/096368912x656090

    Article  PubMed  Google Scholar 

  9. Randelli P et al (2013) Isolation and characterization of 2 new human rotator cuff and long head of biceps tendon cells possessing stem cell-like self-renewal and multipotential differentiation capacity. Am J Sports Med 41:1653–1664. doi:10.1177/0363546512473572

    Article  PubMed  Google Scholar 

  10. Utsunomiya H et al (2013) Isolation and characterization of human mesenchymal stem cells derived from shoulder tissues involved in rotator cuff tears. Am J Sports Med 41:657–668. doi:10.1177/0363546512473269

    Article  PubMed  Google Scholar 

  11. Song N, Armstrong AD, Li F, Ouyang H, Niyibizi C (2014) Multipotent mesenchymal stem cells from human subacromial bursa: potential for cell-based tendon tissue engineering. Tissue Eng Part A 20:239–249. doi:10.1089/ten.TEA.2013.0197

    Article  CAS  PubMed  Google Scholar 

  12. Gulotta LV et al (2009) Application of bone marrow-derived mesenchymal stem cells in a rotator cuff repair model. Am J Sports Med 37:2126–2133. doi:10.1177/0363546509339582

    Article  PubMed  Google Scholar 

  13. Gulotta LV et al (2010) Stem cells genetically modified with the developmental gene MT1-MMP improve regeneration of the supraspinatus tendon-to-bone insertion site. Am J Sports Med 38:1429–1437. doi:10.1177/0363546510361235

    Article  PubMed  Google Scholar 

  14. Gulotta LV, Kovacevic D, Packer JD, Deng XH, Rodeo SA (2011) Bone marrow-derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model. Am J Sports Med 39:1282–1289. doi:10.1177/0363546510395485

    Article  PubMed  Google Scholar 

  15. Yokoya S et al (2012) Rotator cuff regeneration using a bioabsorbable material with bone marrow-derived mesenchymal stem cells in a rabbit model. Am J Sports Med 40:1259–1268. doi:10.1177/0363546512442343

    Article  PubMed  Google Scholar 

  16. Kim YS, Lee HJ, Ok JH, Park JS, Kim DW (2012) Survivorship of implanted bone marrow-derived mesenchymal stem cells in acute rotator cuff tear. J Shoulder Elbow Surg 22:1037–1045. doi:10.1016/j.jse.2012.11.005

    Article  PubMed  Google Scholar 

  17. Shen W et al (2012) Allogenous tendon stem/progenitor cells in silk scaffold for functional shoulder repair. Cell Transplant 21:943–958. doi:10.3727/096368911x627453

    Article  PubMed  Google Scholar 

  18. Ellera Gomes JL, da Silva RC, Silla LM, Abreu MR, Pellanda R (2012) Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells. Knee Surg Sports Traumatol Arthrosc 20:373–377. doi:10.1007/s00167-011-1607-9

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pietro Randelli .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Randelli, P., Menon, A., Ragone, V., Cucchi, D., Cabitza, P. (2017). Stem Cells in Rotator Cuff Healing. In: Gumina, S. (eds) Rotator Cuff Tear. Springer, Cham. https://doi.org/10.1007/978-3-319-33355-7_42

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-33355-7_42

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33354-0

  • Online ISBN: 978-3-319-33355-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics