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Solitary Fibrous Tumor, Soft Tissue

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 31 Accesses

Synonyms

Giant cell angiofibroma; Hemangiopericytoma; Lipomatous solitary fibrous tumor

Definition

A mesenchymal tumor showing fibroblastic differentiation, prominent branching vasculature, and characterized by recurrent NGFI-A binding protein 2-signal transducer and activator of transcription 6 (NAB2-STAT6) gene fusions and variable clinical course.

Clinical Features

  • Incidence

    The true incidence of soft tissue solitary fibrous tumors (SFT) is unknown, but they are thought to comprise approximately 2–3% of all soft tissue tumors, with so-called “malignant” SFT accounting for 0.8% of soft tissue tumors (Gold et al. 2002; Penel et al. 2018).

  • Age

    Soft tissue SFT present with a peak incidence between 40 and 70 years. However, tumors may arise at any age, including the pediatric population.

  • Sex

    There is an equal sex distribution for soft tissue SFT.

  • Site

    SFT can arise at any anatomic site but demonstrate an apparent predilection for the soft tissue of serosalized cavities (pleura and...

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Authors and Affiliations

  1. Departments of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Laboratory Medicine and Pathobiology University of Toronto, Toronto, ON, Canada

    Elizabeth G. Demicco

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  1. Elizabeth G. Demicco
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Correspondence to Elizabeth G. Demicco .

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  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Demicco, E.G. (2020). Solitary Fibrous Tumor, Soft Tissue. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5490-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5490-1

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