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Celiac Disease and Abnormal Pubertal Development

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Abnormal Female Puberty

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Abstract

Celiac disease is a gluten dependent autoimmune enteropathy occurring in genetically susceptible individuals that may manifest as symptoms related to the gastrointestinal tract as well as other organ systems. It is of utmost importance that clinicians recognize that celiac disease may present with or feature abnormal puberty and reproductive dysfunction. Given the complexity of the disease, investigation and management of this autoimmune enteropathy should be done in concert with a gastroenterologist. Diagnosis is especially important given that adherence to a gluten-free diet in patients with celiac disease produces reversal of symptoms. In asymptomatic individuals, who constitute the largest number of cases, diagnosis and subsequent gluten-free diet can be preventative for many of the adverse effects of untreated conditions including certain malignancies.

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Abbreviations

AGA:

American Gastroenterological Society

CD:

Celiac disease

DHEA-S:

Dehydroepiandrosterone sulphate

ELISA:

Enzyme-linked immunosorbent assay

EMA-IgA:

Anti-endomysial IgA

ESPGHAN:

European Society for Pediatric Gastroenterology, Hepatology, and Nutrition

GFD:

Gluten-free diet

HLA:

Human leukocyte antigen

IEL:

Intraepithelial lymphocytes

NASPGHAN:

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

NIH:

National Institutes of Health

TTG-IgA:

Tissue transglutaminase IgA

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Authors and Affiliations

  1. Division of Pediatric Gastroenterology and Nutrition, Cohen Children’s Medical Center of NY/Long Island Jewish Medical Center, 1991 Marcus Avenue, Lake Success, NY, 11042, USA

    Toni Webster D.O., M.Sc. & Michael Pettei M.D., Ph.D.

  2. Hofstra Northwell School of Medicine, Hempstead, NY, USA

    Toni Webster D.O., M.Sc. & Michael Pettei M.D., Ph.D.

Authors
  1. Toni Webster D.O., M.Sc.
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  2. Michael Pettei M.D., Ph.D.
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Corresponding author

Correspondence to Toni Webster D.O., M.Sc. .

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Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Hofstra Northwell School of Medicine, Manhasset, New York, USA

    Heather L. Appelbaum

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Webster, T., Pettei, M. (2016). Celiac Disease and Abnormal Pubertal Development. In: Appelbaum, H. (eds) Abnormal Female Puberty. Springer, Cham. https://doi.org/10.1007/978-3-319-27225-2_10

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  • DOI: https://doi.org/10.1007/978-3-319-27225-2_10

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