Epigenetics and Neuroendocrinology

1. Front Matter

   Pages i-xxiii

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2. Epigenetics and the Stress System

   1. Front Matter

      Pages 1-1

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   2. From Vulnerability to Neurotoxicity: A Developmental Approach to the Effects of Stress on the Brain and Behavior

      • S. J. Lupien, I. Ouellet-Morin, C. M. Herba, R Juster, B. S. McEwen

      Pages 3-48

   3. Dynamic Regulation of Chromatin Modification and Transcription by GR and the Steroid Receptors

      • Charlotte L. George, Becky L. Conway-Campbell

      Pages 49-71

   4. Nuclear Receptor Coactivators

      • Ioannis Zalachoras, Onno C. Meijer

      Pages 73-95

   5. Glucocorticoid-Dependent Epigenetic Regulation of Fkbp5

      • Richard S. Lee

      Pages 97-114

   6. Epigenetic Programming of the HPA Axis by Early Life Adversity

      • Christoph A. Zimmermann, Florian Raabe, Anke Hoffmann

      Pages 115-133

   7. Epigenetic Programming of Hypothalamic Pomc Regulates Feeding and Obesity

      • Asaf Marco, Aron Weller, Noam Meiri

      Pages 135-163

   8. Alterations in DNA Methylation and Hydroxymethylation Due to Parental Care in Rhesus Macaques

      • Nadine Provencal, Renaud Massart, Zsofia Nemoda, Stephen Suomi

      Pages 165-190

   9. Stress, Transposons, and the Brain Epigenome

      • Richard G. Hunter

      Pages 191-205

3. Epigenetics and Sexual Differentiation

   1. Front Matter

      Pages 207-207

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   2. Neuroepigenetics of Sexual Differentiation of Brain and Behavior

      • Margaret M. McCarthy, Sara L. Stockman, Bridget M. Nugent

      Pages 209-232

   3. Differential Regulation of Androgen Receptor and DNA Methylation in Songbirds

      • Kazuhiro Wada

      Pages 233-241

   4. Epigenetic Regulation of the GnRH and Kiss1 Genes

      • Joseph R. Kurian

      Pages 243-264

The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.

• DNA methylation
• epigenetic biomarkers
• gene-environment interactions
• neuroendocrine differentiation
• sex-specific programming
• stress-related psychiatry disorders

“The intended audience … includes researchers studying epigenetics in regard to stress-related psychiatric disorders such post-traumatic stress disorder, anxiety disorders, mood disorders, and eating disorders. Clinicians who would like to stay informed about this interesting research would also benefit from reading this book. … This is an interesting and very informative book on epigenetics and neuroendocrinology in relation to psychiatric disorders and the brain and behavior. … it is a welcome addition to the psychiatric literature.” (Michael Joel Schrift, Doody's Book Reviews, August, 2016)

• Translational Res. in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany

  Dietmar Spengler, Elisabeth Binder

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