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Chromosomal Instability in Cancer Cells pp 1–37Cite as

DNA Repair and Chromosomal Translocations

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 200))

Abstract

The balance between DNA damage, especially double strand breaks, and DNA damage repair is a critical determinant of chromosomal translocation frequency. The non-homologous end-joining repair (NHEJ) pathways seem to play the major role in the generation of chromosomal translocations. The “landscape” of chromosomal translocation identified in malignancies is largely due to selection processes which operate on the growth advantages conveyed to the cells by the functional consequences of chromosomal translocations (i.e., oncogenic fusion proteins and overexpression of oncogenes, both compromising tumor suppressor gene functions). Newer studies have shown that there is an abundance of local rearrangements in many tumors, like small deletions and inversions. A better understanding of the interplay between DNA repair mechanisms and the generation of tumorigenic translocations will, among many other things, depend on an improved understanding of DNA repair mechanisms and their interplay with chromatin and the 3D organization of the interphase nucleus.

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Authors and Affiliations

  1. Faculty of Medical and Health Sciences, Department of Molecular Medicine and Pathology, The University of Auckland, 85 Park Road Grafton, Private Bag 92019, Auckland, 1142, New Zealand

    Stefan K. Bohlander & Purvi M. Kakadia

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  1. Stefan K. Bohlander
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  2. Purvi M. Kakadia
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Correspondence to Stefan K. Bohlander .

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Editors and Affiliations

  1. Visceral and Pediatric Surgery, Department of General, Göttingen, Germany

    B. Michael Ghadimi

  2. Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

    Thomas Ried

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Bohlander, S.K., Kakadia, P.M. (2015). DNA Repair and Chromosomal Translocations. In: Ghadimi, B., Ried, T. (eds) Chromosomal Instability in Cancer Cells. Recent Results in Cancer Research, vol 200. Springer, Cham. https://doi.org/10.1007/978-3-319-20291-4_1

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  • DOI: https://doi.org/10.1007/978-3-319-20291-4_1

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