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The Big Book on Small Heat Shock Proteins

  • Book
  • © 2015

Overview

Editors:
  1. Robert M. Tanguay

    1. Department of Molecular Biology, Medical Biochemistry & Pathology Medical School Lab Cell & Developmental Genetics IBIS, Université Laval, Quebec, Canada

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  2. Lawrence E. Hightower

    1. Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA

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  • A comprehensive account of small HSPs, written by the world’s leading experts
  • In depth reviews on the small Heat Shock Proteins
  • Uniquely covers the whole aspect of small HSP’s from their structure, function to disease implications

Part of the book series: Heat Shock Proteins (HESP, volume 8)

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About this book

Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field.  These colleagues include Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the structure of small heat shock proteins, moving to their functions and finishing with their involvement in diseases. Although this is quite broad, the structural aspect will be the unifying theme of the book.

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-ix
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  2. General Introduction

    1. Front Matter

      Pages 1-1
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    2. The Multicolored World of the Human HSPB Family

      • Harm H. Kampinga, Romy de Boer, Nico Beerstra
      Pages 3-26

    3. Immense Cellular Implications Associated to Small Stress Proteins Expression: Impacts on Human Pathologies

      • André-Patrick Arrigo, Benjamin Ducarouge, Fabrice Lavial, Benjamin Gibert
      Pages 27-83

  3. Structure-Function

    1. Front Matter

      Pages 85-85
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    2. Dynamics-Function Relationships of the Small Heat-Shock Proteins

      • Georg K. A. Hochberg, Justin L. P. Benesch
      Pages 87-100

    3. Insights into How Small Heat Shock Proteins Bind a Great Diversity of Substrate Proteins: A Super-Transformer Model

      • Xinmiao Fu
      Pages 101-117

    4. Model Chaperones: Small Heat Shock Proteins from Plants

      • Indu Santhanagopalan, Eman Basha, Keith N. Ballard, Nathen E. Bopp, Elizabeth Vierling
      Pages 119-153

    5. Regulation of the Chaperone Function of Small Hsps

      • Martin Haslbeck, Sevil Weinkauf, Johannes Buchner
      Pages 155-178

    6. Redefining the Chaperone Mechanism of sHsps: Not Just Holdase Chaperones

      • Heath Ecroyd
      Pages 179-195

    7. Everything but the ACD, Functional Conservation of the Non-conserved Terminal Regions in sHSPs

      • Michelle Heirbaut, Sergei V. Strelkov, Stephen D. Weeks
      Pages 197-227

    8. HSPB6 (Hsp20) as a Versatile Molecular Regulator

      • Maria V. Sudnitsyna, Nikolai N. Sluchanko, Nikolai B. Gusev
      Pages 229-253

    9. The Chloroplast-Localized Plant sHsp in Arabidopsis Thaliana: Role of Its Oligomeric Conformation and Its Translocation into Membranes

      • Katja Bernfur, Gudrun Rutsdottir, Cecilia Månsson, Cecilia Emanuelsson
      Pages 255-266

  4. sHsps in the Clinic

    1. Front Matter

      Pages 267-267
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    2. Multifunctional Roles of αB-Crystallin in Skeletal and Cardiac Muscle Homeostasis and Disease

      • Katie A. Mitzelfelt, Ivor J. Benjamin
      Pages 269-299

    3. Role of Small Heat Shock Protein HspB5 in Cancer

      • Wilbert C. Boelens
      Pages 301-314

    4. Small Heat Shock Proteins and Fibrosis

      • Pierre-Simon Bellaye, Olivier Burgy, Julien Colas, Sebastien Causse, Carmen Garrido, Philippe Bonniaud
      Pages 315-334

    5. Neurodegenerative Diseases, Sex Differences and the 27 kDa Heat Shock Protein in the Nervous System

      • Danielle A. Rioux, Kathleen Murphy, Michael J. Esser, R. William Currie
      Pages 335-363

    6. HspB5/αB-Crystallin in the Brain

      • Nikola Golenhofen, Britta Bartelt-Kirbach
      Pages 365-381

    7. Small HSP Variants and Human Diseases

      • Huan Guo, Tangchun Wu
      Pages 383-397
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Editors and Affiliations

  • Department of Molecular Biology, Medical Biochemistry & Pathology Medical School Lab Cell & Developmental Genetics IBIS, Université Laval, Quebec, Canada

    Robert M. Tanguay

  • Department of Molecular and Cell Biology, University of Connecticut, Storrs, USA

    Lawrence E. Hightower

Bibliographic Information

  • Book Title: The Big Book on Small Heat Shock Proteins

  • Editors: Robert M. Tanguay, Lawrence E. Hightower

  • Series Title: Heat Shock Proteins

  • DOI: https://doi.org/10.1007/978-3-319-16077-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-16076-4Published: 27 June 2015

  • Softcover ISBN: 978-3-319-35807-9Published: 09 October 2016

  • eBook ISBN: 978-3-319-16077-1Published: 15 June 2015

  • Series ISSN: 1877-1246

  • Series E-ISSN: 1877-1254

  • Edition Number: 1

  • Number of Pages: IX, 610

  • Number of Illustrations: 15 b/w illustrations, 53 illustrations in colour

  • Topics: Biomedicine general, Protein Science, Cell Biology

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