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Pathophysiology of Headaches pp 31–66Cite as

Animal Models of Migraine

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Part of the book series: Headache ((HEAD))

Abstract

The headache research field is privileged to have in its preclinical laboratories well-established animal models that significantly facilitate and improve our understanding of headache mechanisms, in particular in terms of the molecular signalling and brain networks involved. A variety of pharmacological screening approaches for novel therapeutics and for the improvement of advanced pharmacological agents can be achieved in translational research utilising these models. The available migraine models have been developed based on our understanding of migraine from clinical, migraine patient-specific evidence. These clinical phenotypes have been successfully employed to model features of the disease physiology in animals and to provide reproducible meaningful physiological measures in the laboratory.

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Authors and Affiliations

  1. Headache Research – Section of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, 369 Fulham Road, London, SW10 9NH, UK

    Anna P. Andreou

  2. National Institute of Neurological Disorders and Stroke, National Institutes of Health, 6001 Executive Blvd, Room 2116, MSC 9521, Bethesda, MD, 20892-9521, USA

    Michael L. Oshinsky

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Correspondence to Anna P. Andreou .

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  1. Department of Neurology, Danish Headache Center Rigshospitalet and Glostrup Hospital, Glostrup, Denmark

    Messoud Ashina

  2. Department of Health Sciences, University of Florence, Florence, Italy

    Pierangelo Geppetti

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Andreou, A.P., Oshinsky, M.L. (2015). Animal Models of Migraine. In: Ashina, M., Geppetti, P. (eds) Pathophysiology of Headaches. Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-15621-7_2

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