Abstract
We have synthesized and characterized a novel zwitterionic nanocomposite hydrogel as effective chronic wound healing dressings. The hydrogel is composited of nonfouling zwitterionic polymer as a major composition, plus small quantity of nano-sized clay for improved mechanical strength and in-situ formation silver nanoparticles for anti-microbial function. The novel zwitterionic nanocomposite hydrogel possesses unique features, including 1. biocmpatibility; 2. high water content; 3. anti-biofouling properties; 4. strong durability; 5. suppression of bacterial growth; 6. controlled release of Ag ions. These features allow developed formulation becoming extraordinary chronic wound dressing for clinical applications.The hydrogel was fabricated via a “one-pot synthesis” approach and the physicochemical properties were characterized detail. Moreover, the antifouling properties of hydrogels were evaluated in contact with a protein and bacterial solutions.
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© 2015 Springer International Publishing Switzerland
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Huang, KT., Huang, CJ. (2015). Novel Zwitterionic Nanocomposite Hydrogel as Effective Chronic Wound Healing Dressings. In: Su, FC., Wang, SH., Yeh, ML. (eds) 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings, vol 47. Springer, Cham. https://doi.org/10.1007/978-3-319-12262-5_11
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DOI: https://doi.org/10.1007/978-3-319-12262-5_11
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-12261-8
Online ISBN: 978-3-319-12262-5
eBook Packages: EngineeringEngineering (R0)