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Double Reduction of Cyclic Aromatic Sulfonamides

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Selectivity in the Synthesis of Cyclic Sulfonamides

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Abstract

Sulfonamides are routinely employed as nitrogen protecting groups in organic synthesis. They are often crystalline, chemically robust, and, most importantly, the basicity/nucleophilicity of the nitrogen atom is reduced dramatically due to the presence of the electron-withdrawing sulfonyl moiety. Unlike their carbamate or amide analogues, there are no spectroscopic problems associated with rotamers when employing sulfonamides as protecting group.

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Authors and Affiliations

  1. HCI F 308, ETH Zürich, Zürich, Switzerland

    Kimberly Geoghegan

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  1. Kimberly Geoghegan
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Correspondence to Kimberly Geoghegan .

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Geoghegan, K. (2014). Double Reduction of Cyclic Aromatic Sulfonamides. In: Selectivity in the Synthesis of Cyclic Sulfonamides. Springer Theses. Springer, Cham. https://doi.org/10.1007/978-3-319-10338-9_5

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