Skip to main content
Book cover

Uveitis pp 135–141Cite as

Ankylosing Spondylitis

  • Chapter
  • First Online:

Abstract

This chapter examines the association between ankylosing spondylitis and uveitis. The epidemiology and genetics of this association are discussed, as well as clinical manifestations and diagnostic testing. The largest focus of this chapter is on treatment modalities, ranging from topical steroids to a number of immunomodulatory therapies.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. What is Ankylosing Spondylitis? Online publication. National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD.

    Google Scholar 

  2. Stolwijk C, van Tubergen A, Castillo-Ortiz JD, Boonen A. Prevalence of extra-articular manifestations in patients with ankylosing spondyolitis: a systematic review and meta-analayis. Ann Rheum Dis. doi:10.1136/annrheumdis-2013-203582.

  3. Brewerton DA, Caffrey M, Hart FD, et al. Ankylosing spondylitis and HLA-B27. Lancet. 1973;1:904.

    Article  CAS  PubMed  Google Scholar 

  4. Zorab PA. The historical and prehistorical background of ankylosing spondylitis. Proc R Soc Med. 1961;54(5):415–20.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Ruffer MA. Studies of the paleopathophysiology of Egypt. Chicago: University of Chicago Press; 1921.

    Google Scholar 

  6. Dieppe P. Did Galen describe rheumatoid arthritis? Ann Rheum Dis. 1988;47(1):84–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Colombo MR. De Re Anatomica. Venice, 1559.

    Google Scholar 

  8. Bechterew W. Steifigkeit der wirbelsaule und ihre verkrummung als besondere erkrankungsform. Neurol Centralbl. 1893;12:426–34.

    Google Scholar 

  9. Strümpell A. Bemerkungen über chronisch-ankylosierende Entzündung der wirbelsoule und der huftergelenks. Deutsch Nervenheilk. 1897;11:338–42.

    Article  Google Scholar 

  10. Marie P. Sur la spondylose rhizomelique. Rev Med. 1898;18:285–315.

    Google Scholar 

  11. Feldtkeller E. Age at disease onset and delayed diagnosis of spondyloarthropathies. Rheumatol. 1999;58:21–30.

    CAS  Google Scholar 

  12. Firestein GS, Budd RC, Gabreil SE, McInnes IB, O’Dell JR. Kelly’s textbook of rheumatology, 9th edn. 75, 1202–1220.e5. Copyright © 2013.

    Google Scholar 

  13. Ankylosing Spondylitis—Profession reference for doctors—Patient UK. Patient UK. Retrieved 22 Dec 2013.

    Google Scholar 

  14. Arthritis Research Campaign—Ankylosing Spondylitis Case History. Arthritis Research Campaign. 2009. Retrieved 25 Aug 2009.

    Google Scholar 

  15. Jimenez-Balderas FJ, Mintz G. Ankylosing spondylitis: clinical course in women and men. J Rheumatol. 1993;20:2069–72.

    CAS  PubMed  Google Scholar 

  16. Singh G, Lawrence A, Agarwal V, Misra R, Aggarwal A. Higher prevalence of extra-articular manifestations in ankylosing spondylitis with peripheral arthritis. J Clin Rheumatol. 2008;14(5):264–6.

    Article  PubMed  Google Scholar 

  17. Van der Horst-Bruinsma IE, Nurmohamed MT. Management and evaluation of extra-articular manifestations in spondyloarthritis. Ther Adv Musculoskel Dis. 2012;4(6):413–22.

    Article  Google Scholar 

  18. Khan M. HLA-B27 and its subtypes in world populations. Curr Opin Rheumatol. 1995;7:263–9.

    Article  CAS  PubMed  Google Scholar 

  19. Braun J, Bollow M, Remlinger G, et al. Prevalence of spondyloarthropathies in HLA-B27 positive and negative blood donors. Arthritis Rheum. 1998;41:58–67.

    Article  CAS  PubMed  Google Scholar 

  20. Baron M, Zendel I. HLA-B27 testing in AS: an analysis of the pre-testing assumptions. J Rheumatol. 1989;16:631–4.

    CAS  PubMed  Google Scholar 

  21. Linssen A, Rothova A, Valkenburg HA, Dekker-Saeys AJ, Luyendiik L, Kijlstra A, Feltkamp TE. The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27. Invest Ophthalmol Vis Sci. 1991;32(9):2568–78.

    CAS  PubMed  Google Scholar 

  22. Feldtkerr E, Khan M, Hejde D, Linden S, Braun J. Age of disease onset and diagnosis delay in HLA-B27 negative vs positive patients with ankylosing spondylitis. Rheumatol Int. 2003;23(2):61–66.

    Google Scholar 

  23. Lee Y, Choi S, Ji J, Song G. Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis. Inflamm Res. 2011;60(11):999–1003.

    Google Scholar 

  24. Brophy S, Pavy S, Lewis P, Taylor G, Bradbury L, Robertson D, et al. Inflammatory eye, skin, and bowel disease in spondyloarthritis: genetic, phenotypic, and environmental factors. J Rheumatol. 2001;28:2667–73.

    CAS  PubMed  Google Scholar 

  25. Chou CT. Factors affecting the pathogenesis of ankylosing spondylitis. Chin Med J (Engl). 2001;114:212–3.

    Google Scholar 

  26. Resnick D. Niwayama G: Ankylosing spondylitis. Diagnosis of bone and joint disorders. Philadelphia: WB Saunders; 1988. p. p1103.

    Google Scholar 

  27. Khan MA. Ankylosing spondylitis: introductory comments on its diagnosis and treatment. Ann Rheum Dis. 2002;61:iii3–iii7.

    Google Scholar 

  28. Van der Linden S, Valkenburg H, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. a proposal for modification of the New York criteria. Arthritis Rheum. 1984;27:361–8.

    Article  PubMed  Google Scholar 

  29. Huerta-Sil G, Casasola-Vargas J, Londono J, et al. Low grade radiographic sacroiliitis as prognostic factor in patients with undifferentiated spondyloarthritis fulfilling diagnostic criteria for ankylosing spondylitis throughout follow up. Ann Rheum Dis. 2006;65:642–6.

    Article  CAS  PubMed  Google Scholar 

  30. Klauser A, Bollow M, Calin A, et al. Workshop report: Clinical diagnosis and imaging of sacroiliitis, Innsbruck, Austria, October 9, 2003. J Rheumatol. 2004;31:2041–7.

    PubMed  Google Scholar 

  31. Oostveen J, Prevo R, den Boer J, van de Laar M. Early detection of sacroiliitis on magnetic resonance imaging and subsequent development of sacroiliitis on plain radiography. A prospective, longitudinal study. J Rheumatol. 1999;26:1953–8.

    Google Scholar 

  32. Rodriguez A, Akova YA, Pedroza-Seres M, Foster CS. Posterior segment ocular manifestations in patients with HLA_B27-associated uveitis. Ophthalmology. 1994;101(7):1267–74.

    Article  CAS  PubMed  Google Scholar 

  33. de la Maza MS, Jabbur NS, Foster CS. Severity of scleritis and episcleritis. Ophthalmology. 1994;101:389.

    Article  Google Scholar 

  34. Foster CS, de la Maza MS. The sclera. New York: Springer; 1994.

    Book  Google Scholar 

  35. Foster CS, Davanzo R, Flynn TE, McLeod K, Vogel R, Crockett RS. Durezol (Difluprednate Ophthalmic Emulsion 0.05 %) compared with Pred Forte 1 % ophthalmic suspension in the treatment of endogenous anterior uveitis. J Ocul Pharacol Ther. 2010;26(5):475–83.

    Google Scholar 

  36. Maksymowych WP. Update on the treatment of ankylosing spondylitis. Ther Clin Risk Manag. 2007;3(6):1125–33.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Wanders A, Heijde DV, Landewe R, Beheir JM, Calin A, Olivieri I, Zeidler H, Dougados M. Nonsteroid anti-inflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis: a randomized clinical trial. Arthritis Rheum. 2005;52(6):1756–65.

    Google Scholar 

  38. Fiorelli VM, Bhat P, Foster CS. Nonsteroidal anti-inflammatory therapy and recurrent acute anterior uveitis. Ocul Immunol Inflamm. 2010;18(2):116–20.

    Article  PubMed  Google Scholar 

  39. Jabs DA, Rosenbaum JT, Foster CS, Holland GN, Jaffe GJ, Louie JS, Nussenblatt RB, Stiehm ER, Tessler H, Van Gelder RN, Whitcup SM, Yocum D. Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panels. Am J Ophthalmol. 130(4):492–513.

    Google Scholar 

  40. Samson CM, Waheed N, Baltatzis S, Foster CS. Methotrexate therapy for chronic noninfectious uveitis; Analysis of a case series of 160 patients. Ophthalmology. 108(6):1134–1139.

    Google Scholar 

  41. Chen J, Veras MM, Liu C, Lin J. Methotrexate for ankylosing spondylitis. Cochrane Database Syst Rev. 2013;28:2.

    Google Scholar 

  42. Chen J, Liu C. Review Is sulfasalazine effective in ankylosing spondylitis? A systematic review of randomized controlled trials. J Rheumatol. 2006;33(4):722–31.

    CAS  PubMed  Google Scholar 

  43. Zou JX, Braun J, Sieper J. Immunological basis for the use of TNF-blocking agents in ankylosing spondylitis and immunological changes during treatment. Clin Exp Rheumatol 2002;20 (Suppl. 28).

    Google Scholar 

  44. Foster CS, Tufail F, Waheed N, Chu D, Miserocchi E, Baltatzis S, Vredeveld C. Efficacy of Etanercept in preventing relapse of uveitis controlled by Methotrexate. Arch Ophthalmol. 2003;121(4):437–40.

    Article  CAS  PubMed  Google Scholar 

  45. Taban M, Dupps WJ, Mandell B, Perez VL. Etanercept (enbrel)-associated inflammatory eye disease: case report and review of the literature. Ocular Immunology and Inflammation. 2006;14(3):145–50.

    Article  PubMed  Google Scholar 

  46. Suhler EB, Smith JR, Wertheim MS, Lauer AK, Kurz DE, Pickard TD, Rosenbaum JT. A prospective trial of infliximab therapy for refractory uveitis. Arch Ophthalmol. 2005;123(7):903–12.

    Article  CAS  PubMed  Google Scholar 

  47. Artornsombudh P, Gevorgyan O, Payal A, Siddique S, Foster CS. Infliximab treatment of patients with birdshot retinochoroidopathy. Ophthalmology. 120(3);588–592.

    Google Scholar 

  48. Jaffe G, Dick AD, Brezin AP, Nguyen QD, Thorne JE, Kestelyn P, et al. Adalimumab in patients with active noninfectious uveitis. N Engl J Med 2016; 375(10): 932–43.

    Google Scholar 

  49. William M, Faez S, Papaliodis G, Lobo AM. Golimumab for the treatment of refractory juvenile idiopathic arthritis-associated uveitis. J Ophthal Inflamm Infect. 2012;2:231.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mark Dacey .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Dacey, M. (2017). Ankylosing Spondylitis. In: Papaliodis, G. (eds) Uveitis. Springer, Cham. https://doi.org/10.1007/978-3-319-09126-6_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-09126-6_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09125-9

  • Online ISBN: 978-3-319-09126-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics