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Handbook of Anticancer Drugs from Marine Origin pp 113–144Cite as

Cytotoxic Cyclic Peptides from the Marine Sponges

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Abstract

To date, a significant number of cyclic peptides have been isolated from the marine sponges. Their structures often contain non-proteinogenic amino acids, some of which are derived from the biosynthetic pathway mixed with polyketides synthase. Halogenation, N-formylation, and racemaization to D-isomers were also frequently observed. Here we review the structural features of cytotoxic cyclic peptides from marine sponges. The cyclic peptides and depsipeptides were classified into different cyclization ways. The recent progress on the studies of their mode of action and biosynthesis was also included.

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Authors and Affiliations

  1. Lab of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan

    Assoc. Prof. Toshiyuki Wakimoto, Karen Co Tan, Hiroki Tajima & Prof. Ikuro Abe

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  1. Assoc. Prof. Toshiyuki Wakimoto
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  2. Karen Co Tan
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  3. Hiroki Tajima
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  4. Prof. Ikuro Abe
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Correspondence to Toshiyuki Wakimoto .

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  1. Department of Marine-Bio Convergence Science, Pukyong National University, Busan, Korea, Republic of (South Korea)

    Se-Kwon Kim

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Wakimoto, T., Tan, K., Tajima, H., Abe, I. (2015). Cytotoxic Cyclic Peptides from the Marine Sponges. In: Kim, SK. (eds) Handbook of Anticancer Drugs from Marine Origin. Springer, Cham. https://doi.org/10.1007/978-3-319-07145-9_6

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