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Polysaccharides from the Fungus Scleroderma/Fungi

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Polysaccharides

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Abstract

Research with natural products is an alternative, which includes several bioproducts from bacteria, plant, animal, insect, and marine organisms. Such bioproducts include polysaccharides, proteins, dietary fibers, and many other biomolecules. Studies on fungus have attracted considerable interest for its application in the pharmaceutical and food industry. The anti-inflammatory potential of polysaccharides from the fungus Scleroderma nitidum Berk. and their possible action mechanism were studied. The effect of these polymers on the inflammatory process was tested using the carrageenan- and histamine-induced paw edema model and the sodium thioglycolate- and zymosan-induced models. The polysaccharides from S. nitidum were effective in reducing edema and cell infiltrate in both inflammation models tested. Nitric oxide, a mediator in the inflammatory process, also showed a low reduction. Analysis of pro- and anti-inflammatory cytokines showed that in the groups treated with polysaccharides from S. nitidum, there was an increase in cytokines such as IL-1ra, IL-10, and MIP-1β concomitant with the decrease in 17INF-γ and IL-2. The influence of polysaccharides on the modulation of the expression of nuclear factor κB showed that this compound reduced the expression of NF-κB by up to 64 %. This suggests that NF-κB modulation also explains the anti-inflammatory effect of polysaccharides from the fungus S. nitidum.

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Acknowledgments

The authors would like to thank the Brazilian agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior for financial support. The author would like thank the student Diego Gomes for help in graphics.

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  1. Laboratory of Glycobiology, Department of Biochemistry, Federal University of Rio Grande do Norte, Av. Salgado Filho, 3000, Bairro L. Nova, CEP: 59072-970, Natal, RN, Brazil

    Marília da Silva Nascimento Santos & Edda Lisboa Leite

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  1. Marília da Silva Nascimento Santos
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  2. Edda Lisboa Leite
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Correspondence to Edda Lisboa Leite .

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  1. Botany Department, M.L.Sukhadia University, Badgaon, India

    Kishan Gopal Ramawat

  2. Institut des Sciences de la Vigne et du Vin, Université de Bordeaux, Villenave d'Ornon, France

    Jean-Michel Mérillon

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da Silva Nascimento Santos, M., Leite, E.L. (2014). Polysaccharides from the Fungus Scleroderma/Fungi . In: Ramawat, K., Mérillon, JM. (eds) Polysaccharides. Springer, Cham. https://doi.org/10.1007/978-3-319-03751-6_19-1

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  • DOI: https://doi.org/10.1007/978-3-319-03751-6_19-1

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