Skip to main content

Advances in vasospasm research

  • Conference paper
  • First Online:
Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 104))

Abstract

A literature search on cerebral vasospasm yielded many research articles on the pathogenesis and management of cerebral vasospasm. A review was done touching on pathogenesis and pathophysiology, concentrating mainly on the prevention and treatment of vasospasm. A number of lines of treatment are under investigation. The main treatments to have reached the stage of clinical trial are endothelin antagonists, magnesium sulphate, and members of the statin group of drugs. Variations on calcium antagonists and cerebrospinal fluid drainage have also been reviewed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Andaluz N, Zuccarello M (2004) Fenestration of the lamina terminalis as a valuable adjunct in aneurysm surgery. Neurosurgery 55: 1050–1059

    Article  Google Scholar 

  2. Belfort MA, Anthony J, Saade GR, Allen JC Jr, Nimodipine Study Group (2003) A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. New Eng J Med 348: 304–311

    Article  CAS  Google Scholar 

  3. van den Bergh WM, Algra A, van Kooten F, Dirven CM, van Gijn J, Vermeulen M, Rinkel GJ (2005) Magnesium sulfate in aneurysmal subarachnoid hemorrhage: a randomized controlled trial. Stroke 36: 1011–1015

    Article  Google Scholar 

  4. van den Bergh WM, Dijkhuizen RM, Rinkel GJ (2004) Potentials of magnesium treatment in subarachnoid haemorrhage. Magnesium Res 17: 301–313

    Google Scholar 

  5. Chia RY, Hughes RS, Morgan MK (2002) Magnesium: a useful adjunct in the prevention of cerebral vasospasm following aneurysmal subarachnoid haemorrhage. J Clin Neurosci 9: 279–281

    Article  CAS  Google Scholar 

  6. Dalbasti T, Karabiyikoglu M, Ozdamar N, Oktar N, Cagli S (2001) Efficacy of controlled-release papaverine pellets in preventing symptomatic cerebral vasospasm. J Neurosurg 95: 44–50

    Article  CAS  Google Scholar 

  7. Dorsch NWC, King MT (1994) A review of cerebral vasospasm in aneurysmal subarachnoid haemorrhage. Part I: Incidence and effects. J Clin Neurosci 1: 19–26

    Article  CAS  Google Scholar 

  8. Hansen-Schwartz J (2004) Cerebral vasospasm: a consideration of the various cellular mechanisms involved in the pathophysiology. Neurocrit Care 1: 235–246

    Article  CAS  Google Scholar 

  9. Jeng AY, Mulder P, Kwan AL, Battistini B (2002) Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications [Review]. Can J Physiol Pharmacol 80: 440–449

    Article  CAS  Google Scholar 

  10. Kasuya H, Onda H, Sasahara A, Takeshita M, Hori T (2005) Application of nicardipine prolonged-release implants: analysis of 97 consecutive patients with acute subarachnoid hemorrhage. Neurosurgery 56: 895–902

    PubMed  Google Scholar 

  11. Kessler IM, Pacheco YG, Lozzi SP, de Araujo AS Jr, Onishi FJ, de Mello PA (2005) Endothelin-1 levels in plasma and cerebrospinal fluid of patients with cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Surg Neurol 64[Suppl 1]: 2–5

    Article  Google Scholar 

  12. Klimo P Jr, Kestle JR, MacDonald JD, Schmidt RH (2004) Marked reduction of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage. J Neurosurg 100: 215–224

    Article  Google Scholar 

  13. Lin CL, Jeng AY, Howng SL, Kwan AL (2004) Endothelin and subarachnoid hemorrhage-induced cerebral vasospasm: pathogenesis and treatment. Curr Med Chem 11: 1779–1791

    Article  CAS  Google Scholar 

  14. Lynch JR, Wang H, McGirt MJ, Floyd J, Friedman AH, Coon AL, Blessing R, Alexander MJ, Graffagnino C, Warner DS, Laskowitz DT (2005) Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial. Stroke 36: 2024–2026

    Article  CAS  Google Scholar 

  15. Ono K, Matsumori A (2002) Endothelin antagonism with bosentan: current status and future perspectives [Review]. Cardiovasc Drug Rev 20: 1–18

    Article  CAS  Google Scholar 

  16. Parra A, Kreiter KT, Williams S, Sciacca R, Mack WJ, Naidech AM, Commichau CS, Fitzsimmons BF, Janjua N, Mayer SA, Connolly ES Jr (2005) Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurysmal subarachnoid hemorrhage: a matched controlled cohort study. Neurosurgery 56: 476–484

    Article  Google Scholar 

  17. Pluta RM (2005) Delayed cerebral vasospasm and nitric oxide: review, new hypothesis, and proposed treatment. Pharmacol Ther 105: 23–56

    Article  CAS  Google Scholar 

  18. Prevedello DM, Corseiro JG, de Morais AL, Saucedo NS Jr, Chen IB, Araujo JC (2006) Magnesium sulfate: role as possible attenuating factor in vasospasm morbidity. Surg Neurol 65Suppl 1: 14–20

    Article  Google Scholar 

  19. Suhardja A (2004) Mechanisms of disease: roles of nitric oxide and endothelin-1 in delayed cerebral vasospasm produced by aneurysmal subarachnoid hemorrhage. Nat Clin Pract Cardiovasc Med 1: 110–116

    Article  CAS  Google Scholar 

  20. Tseng MY, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2005) Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial. Stroke 36: 1627–1632

    Article  CAS  Google Scholar 

  21. Vajkoczy P, Meyer B, Weidauer S, Raabe A, Thome C, Ringel F, Breu V, Schmiedek P (2005) Clazosentan (AXV-034343), a selective endothelin A receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: results of a randomized, double-blind, placebo-controlled, multicenter phase IIa study. J Neurosurg 103: 9–17

    Article  CAS  Google Scholar 

  22. Vatter H, Zimmermann M, Seifert V, Schilling L (2004) Experimental approaches to evaluate endothelin-A receptor antagonists. Meth Find Exp Clin Pharmacol 26: 277–286

    CAS  Google Scholar 

  23. Veyna RS, Seyfried D, Burke DG, Zimmerman C, Mlynarek M, Nichols V, Marrocco A, Thomas AJ, Mitsias PD, Malik GM (2002) Magnesium sulfate therapy after aneurysmal subarachnoid hemorrhage. J Neurosurg 96: 510–514

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nicholas W. C. Dorsch .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag

About this paper

Cite this paper

Murray, M., Dorsch, N.W.C. (2008). Advances in vasospasm research. In: Kırış, T., Zhang, J.H. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplement, vol 104. Springer, Vienna. https://doi.org/10.1007/978-3-211-75718-5_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-211-75718-5_1

  • Published:

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-75717-8

  • Online ISBN: 978-3-211-75718-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics