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Viral infection

  • Chapter
Stress-Inducible Cellular Responses

Part of the book series: EXS ((EXS,volume 77))

Summary

The relationship between viruses and the cellular stress response is a multifaceted and complex phenomenon which depends on the structural and genetic characteristics of the virus, on the type of infection, as well as on the environmental conditions. It is now well documented that infection of mammalian cells by several types of RNA and DNA viruses often results in alterations of the cellular stress response. Interactions between stress proteins and viral components have been described in a large variety of experimental models at different stages of the viral life cycle, depending on the type of virus and host cell. The presence of heat shock proteins in intact virions has also been described. On the other hand, induction of HSP expression by hyperthermia or other agents results in alterations of the virus replication cycle during acute or persistent infections of mammalian cells, and a possible role of heat shock proteins in the beneficial effect of fever and local hyperthermia during acute infection has been hypothesized. This chapter describes the different aspects of the interaction between viruses and the stress response, and discusses the possible role of stress proteins in the control of virus replication and morphogenesis.

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Authors and Affiliations

  1. Institute of Experimental Medicine, CNR, V.le K. Marx, 15/43-I-00137, Rome, Italy

    M. G. Santoro

  2. Department of Experimental Medicine, University of L’Aquila, I-67200, L’Aquila, Italy

    M. G. Santoro

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  1. Department of Pharmacology, AMGEN Center, 1840 De Havilland Drive, 15-2-A-224, 91320-1789, Thousand Oaks, CA, USA

    U. Feige

  2. Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-Ku, Tokyo 113, Japan

    I. Yahara

  3. Department of Biochemistry, Molecular and Cell Biology Northwestern University, 2153 Sheridan Road, 60208-3500, Evanston, IL, USA

    R. I. Morimoto

  4. Laboratoire de Physiologie Respiratoire, Université Paris 5 UFR Cochin Port-Royal, 24, rue du Faubourg Saint-Jacques, F-75014, Paris, France

    B. S. Polla

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Santoro, M.G. (1996). Viral infection. In: Feige, U., Yahara, I., Morimoto, R.I., Polla, B.S. (eds) Stress-Inducible Cellular Responses. EXS, vol 77. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9088-5_23

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  • DOI: https://doi.org/10.1007/978-3-0348-9088-5_23

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9901-7

  • Online ISBN: 978-3-0348-9088-5

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