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Preliminary Study of Cerebral Myelin Content Alterations at Schizophrenia

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Biologically Inspired Cognitive Architectures 2023 (BICA 2023)

Part of the book series: Studies in Computational Intelligence ((SCI,volume 1130))

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Abstract

At the moment, the study of the association of different brain areas with schizophrenia is a thriving field of research. Although the precise mechanisms underlying the development of schizophrenia remain not fully understood, ongoing research enhances our understanding of which areas of the brain may be associated with various symptoms and behavioral disturbances in patients with the disease. Pathological changes in the brain may be accompanied by a decrease in the level of myelin. The results obtained in the present study support the hypothesis of an association between brain myelination and the development of schizophrenia. The present study revealed reduced myelination in the number of areas which can be divided into several groups based on common features. In our work, significant changes were found in the following areas of the brain: Heschl’s Gyrus (includes H1 and H2), Postcentral Gyrus, Lateral Occipital Cortex superior division, Frontal Pole, Paracingulate Gyrus, Inferior frontal gyrus, Middle frontal gyrus. In the future, the results of the study can be used to create a non-invasive quantitative marker of schizophrenia. This will allow, on the one hand, to characterize the current stage of the disease of a particular patient in terms of myelination abnormalities, and on the other hand, it can help shed light on the etiology of this disease.

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Acknowledgements

This work was in part supported by Russian Science Foundation grant â„– 20-15-00299-P (https://rscf.ru/en/project/20-15-00299-P/, data acquisition, statistical and neurophysiological analysis) and grant â„– 22-11-00213 (data preprocessing).

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Authors and Affiliations

  1. Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russia

    Ekaterina Krupina, Andrei Manzhurtsev & Maxim Ublinskiy

  2. National Research Nuclear University MEPhI, Moscow, Russia

    Ekaterina Krupina, Larisa Mosina & Vadim Ushakov

  3. Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Moscow, Russia

    Maria Osetrova

  4. Laboratory of Neurobiology, Tomsk State University, Tomsk, Russia

    Vasily Yarnykh

  5. Department of Radiology, University of Washington, Seattle, WA, USA

    Vasily Yarnykh

  6. Mental Health Clinic No. 1 named after N.A. Alexeev of Moscow Health Department, Moscow, Russia

    Galina Mamedova, Sergey Trushchelev, Natalia Zakharova, Georgy Kostyuk & Vadim Ushakov

  7. Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, Russia

    Vadim Ushakov

Authors
  1. Ekaterina Krupina
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  2. Andrei Manzhurtsev
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  3. Maxim Ublinskiy
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  4. Larisa Mosina
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  5. Maria Osetrova
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  6. Vasily Yarnykh
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  7. Galina Mamedova
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  8. Sergey Trushchelev
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  9. Natalia Zakharova
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  10. Georgy Kostyuk
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  11. Vadim Ushakov
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Correspondence to Ekaterina Krupina .

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Editors and Affiliations

  1. Cybernetics Department, Moscow Engineering Physics Institute, Moscow, Russia

    Alexei V. Samsonovich

  2. College of Science and Technology, Ningbo University, Ningbo, China

    Tingting Liu

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Krupina, E. et al. (2024). Preliminary Study of Cerebral Myelin Content Alterations at Schizophrenia. In: Samsonovich, A.V., Liu, T. (eds) Biologically Inspired Cognitive Architectures 2023. BICA 2023. Studies in Computational Intelligence, vol 1130. Springer, Cham. https://doi.org/10.1007/978-3-031-50381-8_51

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