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General Morphology of the Mammalian Carotid Body

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Morphofunctional and Neurochemical Aspects of the Mammalian Carotid Body

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 237))

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Abstract

The carotid body (CB) is the main peripheral arterial chemoreceptor that registers the levels of pO2, pCO2 and pH in the blood and responds to their changes by regulating breathing. It is strategically located in the bifurcation of each common carotid artery. The organ consists of “glomera” composed of two cell types, glomus and sustentacular cells, interspersed by blood vessels and nerve bundles and separated by connective tissue. The neuron-like glomus or type I cells are considered as the chemosensory cells of the CB. They contain numerous cytoplasmic organelles and dense-cored vesicles that store and release neurotransmitters. They also form both conventional chemical and electrical synapses between each other and are contacted by peripheral nerve endings of petrosal ganglion neurons. The glomus cells are dually innervated by both sensory nerve fibers through the carotid sinus nerve and autonomic fibers of sympathetic origin via the ganglioglomerular nerve. The parasympathetic efferent innervation is relayed by vasomotor fibers of ganglion cells located around or inside the CB. The glial-like sustentacular or type II cells are regarded to be supporting cells although they sustain physiologic neurogenesis in the adult CB and are thus supposed to be progenitor cells as well. The CB is a highly vascularized organ and its intraorgan hemodynamics possibly plays a role in the process of chemoreception.

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References

  • Arias-Stella J, Valcarcel J (1976) Chief cell hyperplasia in the human carotid body at high altitudes; physiologic and pathologic significance. Hum Pathol 7:361–373

    Article  CAS  PubMed  Google Scholar 

  • Atanasova DY, Lazarov NE (2015) Histochemical demonstration of tripeptidyl aminopeptidase I in the rat carotid body. Acta Histochem 117:219–222

    Article  CAS  PubMed  Google Scholar 

  • Atanasova DY, Iliev ME, Lazarov NE (2011) Morphology of the rat carotid body. Biomed Rev 22:41–55

    Article  CAS  Google Scholar 

  • Atanasova D, Dandov A, Kirov T, Lazarov NE (2018) Mast cells in the rat carotid body. Acta Morphol Anthropol 25:11–15

    Google Scholar 

  • Ballard T, Blakeman N, Pallot DJ, Al-Neamy KA (1982) Quantitative ultrastructural studies of the cat carotid body. I. General stereology of tissue components. Acta Anat (Basel) 113:47–52

    Article  CAS  PubMed  Google Scholar 

  • Barnett S, Mulligan E, Wagerle LC, Lahiri S (1988) Measurement of carotid body blood flow in cats by use of radioactive microspheres. J Appl Physiol 65:2484–2489

    Article  CAS  PubMed  Google Scholar 

  • Biscoe TJ (1971) Carotid body: structure and function. Physiol Rev 51:437–495

    Article  CAS  PubMed  Google Scholar 

  • Biscoe TJ, Sampson SR (1968) Rhythmical and non-rhythmical spontaneous activity recorded from the central cut end of the sinus nerve. J Physiol 196:327–338

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Biscoe TJ, Stehbens WE (1967) Ultrastructure of the denervated carotid body. Quart J Exp Physiol 52:31–36

    Article  Google Scholar 

  • Brognara F, Felippe ISA, Salgado HC, Paton JFR (2021) Autonomic innervation of the carotid body as a determinant of its sensitivity: implications for cardiovascular physiology and pathology. Cardiovasc Res 117:1015–1032

    Article  CAS  PubMed  Google Scholar 

  • Campanucci VA, Nurse CA (2007) Autonomic innervation of the carotid body: role in efferent inhibition. Respir Physiol Neurobiol 157:83–92

    Article  CAS  PubMed  Google Scholar 

  • Clarke JA, de Burgh Daly M (1981) A comparative study of the distribution of carotid body type-I cells and periadventitial type-I cells in the carotid bifurcation regions of the rabbit, rat, guinea-pig and mouse. Cell Tissue Res 220:753–772

    Article  CAS  PubMed  Google Scholar 

  • Clarke JA, de Burgh Daly MD, Ead HW (1986) Dimensions and volume of the carotid body in the adult cat, and their relation to the specific blood-flow through the organ. A histological and morphometric study. Acta Anat 126:84–86

    Article  CAS  PubMed  Google Scholar 

  • Conde SV, Sacramento JF, Martins FO (2020) Immunity and the carotid body: implications for metabolic diseases. Bioelectron Med 6:24

    Article  PubMed  PubMed Central  Google Scholar 

  • De Burgh Daly M (1997) Peripheral arterial chemoreceptors and respiratory-cardiovascular integration, 1st edn. Clarendon Press, Oxford, UK

    Book  Google Scholar 

  • De Burgh Daly M, Lambertsen CJ, Schweitzer A (1954) Observations on the volume of blood flow and oxygen utilization of the carotid body in the cat. J Physiol 125:67–89

    Article  PubMed  Google Scholar 

  • De Caro R, Macchi V, Sfriso MM, Porzionato A (2013) Structural and neurochemical changes in the maturation of the carotid body. Resp Physiol Neurobiol 185:9–19

    Article  Google Scholar 

  • De Castro F (1926) Sur la structure et l’innervation de la glande intercarotidienne (glomus caroticum) de l’homme et des mammifères, et sur un noveau système d’innervation autonome du nerf glossopharyngien. Trab Lab Invest Biol Univ Madrid 24:365–432

    Google Scholar 

  • De Castro F, Rubio M (1968) The anatomy and innervation of the blood vessels of the carotid body and the role of chemoreceptive reactions in the autoregulation of the blood flow. In: Torrance RW (ed) Arterial chemoreceptors. Proceedings of Wates symposium, Blackwell, Oxford, pp 267–278

    Google Scholar 

  • Ding Y, Li Y-L, Schultz HD (2011) Role of blood flow in carotid body chemoreflex function in heart failure. J Physiol 589:245–258

    Article  CAS  PubMed  Google Scholar 

  • Duchen MR, Biscoe TJ (1992) Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors. J Physiol 450:13–31

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dvorakova M, Höhler B, Vollerthun R, Fischbach T, Kummer W (2000) Macrophages: a major source of cytochrome b558 in the rat carotid body. Brain Res 852:349–354

    Article  CAS  PubMed  Google Scholar 

  • Eyzaguirre C (2000) Carotid body gap junctions: secretion of transmitters and possible electric coupling between glomus cells and nerve terminals. Adv Exp Med Biol 475:349–357

    Article  CAS  PubMed  Google Scholar 

  • Eyzaguirre C, Abudara V (1996) Reflection on the carotid nerve sensory discharge and coupling between glomus cells. Adv Exp Med Biol 10:159–167

    Article  Google Scholar 

  • Eyzaguirre C, Uchizono K (1961) Observations on the fibre content of nerves reaching the carotid body of the cat. J Physiol 159:268–281

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eyzaguirre C, Fitzgerald RS, Lahiri S, Zapata P (1983) Arterial chemoreceptors. In: Shepherd JT, Abboud FM (eds) Handbook of physiology, vol 3. Williams & Wilkins, Baltimore, pp 557–621

    Google Scholar 

  • Fay FS (1970) Oxygen consumption of the carotid body. Am J Physiol 218:518–523

    Article  CAS  PubMed  Google Scholar 

  • Fidone SJ, Sato A (1969) A study of chemoreceptor and baroreceptor A and C-fibres in the cat carotid nerve. J Physiol 205:527–548

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fujita T (1977) Concept of paraneurons. Arch Histol Jpn 40(Suppl):1–12

    Article  CAS  PubMed  Google Scholar 

  • Fujita T, Kanno T, Kobayashi S (1988) The paraneuron. Springer Verlag, Heidelberg

    Book  Google Scholar 

  • Gold OMS, Bardsley EN, Ponnampalam AP, Pauza AG, Paton JFR (2022) Cellular basis of learning and memory in the carotid body. Front Synaptic Neurosci 14:90231

    Article  Google Scholar 

  • Gomez LP (1908) The anatomy and pathology of the carotid gland. Am J Med Sci 136:98–110

    Article  Google Scholar 

  • González C, Almaraz L, Obeso A, Rigual R (1994) Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol Rev 74:829–898

    Article  PubMed  Google Scholar 

  • González C, Sanz-Alfayate G, Obeso A, Agapito MT (2004) Role of glutathione redox state in oxygen sensing by carotid body chemoreceptor cells. In: Sen CK, Semenza GL (eds) Oxygen sensing, methods in enzymology, vol 381. Elsevier, pp 40–71

    Chapter  Google Scholar 

  • Grimley PM, Glenner GG (1968) Ultrastructure of the human carotid body: a perspective on the mode of chemoreception. Circulation 37:648–665

    Article  CAS  PubMed  Google Scholar 

  • Habeck JO (1986) Morphological findings at the carotid bodies of humans suffering from different types of systemic hypertension or severe lung diseases. Anat Anz 162:17–27

    CAS  PubMed  Google Scholar 

  • Habeck JO, Honig A, Huckstorf C, Pfeiffer C (1984) Arteriovenous anastomoses at the carotid bodies of rats. Anat Anz 156:209–215

    CAS  PubMed  Google Scholar 

  • Heath D (1991) The human carotid body in health and disease. J Pathol 164:1–8

    Article  CAS  PubMed  Google Scholar 

  • Heath D, Smith P (1985) The pathology of the carotid body and sinus. Edward Arnold, London

    Google Scholar 

  • Heath D, Edwards C, Harris P (1970) Post-mortem size and structure of the human carotid body. Thorax 25:129–140

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heath D, Jago R, Smith P (1983) The vasculature of the carotid body. Cardiovasc Res 17:33–42

    Article  CAS  PubMed  Google Scholar 

  • Heath D, Lowe O, Smith P (1987) Mast cells in the human carotid body. J Comp Pathol 40:9–12

    CAS  Google Scholar 

  • Hellström S (1975) Morphometric studies of dense-cored vesicles in type I cells of rat carotid body. J Neurocytol 4:77–86

    Article  PubMed  Google Scholar 

  • Hess A, Zapata P (1972) Innervation of the cat carotid body: normal and experimental studies. Fed Proc 31:1365–1382

    CAS  PubMed  Google Scholar 

  • Ichikawa H (2002) Innervation of the carotid body: immunohistochemical, denervation, and retrograde tracing studies. Misrosc Res Tech 59:188–195

    Article  CAS  Google Scholar 

  • Ichikawa H, Rabchevsky A, Helke CJ (1993) Presence and coexistence of putative neurotransmitters in carotid sinus baro- and chemoreceptor afferent neurons. Brain Res 611:67–74

    Article  CAS  PubMed  Google Scholar 

  • Iturriaga R, Alcayaga J (2004) Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals. Brain Res Rev 47:46–53

    Article  CAS  PubMed  Google Scholar 

  • Kameda Y (1996) Ultrastructural immunogold localization of vimentin and S-100 protein in guinea pig pars tuberalis. J Histochem Cytochem 44:511–518

    Article  CAS  PubMed  Google Scholar 

  • Keller HP, Lübbers DW (1972) Flow measurement in the carotid body of the cat by the hydrogen clearance method. Pflügers Arch 336:217–224

    Article  CAS  PubMed  Google Scholar 

  • Khan Q, Heath D, Smith P (1988) Anatomical variations in human carotid bodies. J Clin Pathol 41:1196–1199

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kohn A (1900) Über den Bau und die Entwicklung der sogenanten Carotisdrüse. Arch Mikrosk Anat 56:81–148

    Article  Google Scholar 

  • Kohn A (1903) Die paraganglien. Arch Mikrosk Anat 62:263–365

    Article  Google Scholar 

  • Kondo H (1976) Innervation of the carotid body of the adult rat. A serial ultrathin section analysis. Cell Tissue Res 173:1–15

    Article  CAS  PubMed  Google Scholar 

  • Kondo H (1977) Innervation of the chief cells of the carotid body: an ultrastructural review. Arch Histol Jpn 40:221–230

    Article  PubMed  Google Scholar 

  • Kondo H (2002) Are there gap junctions between chief (glomus, type I) cells in the carotid body chemoreceptor? A review. Microsc Res Tech 59:227–233

    Article  PubMed  Google Scholar 

  • Kondo H, Iwasa H (1996) Re-examination of the carotid body ultrastructure with special attention to intercellular membrane appositions. Adv Exp Med Biol 410:45–50

    Article  CAS  PubMed  Google Scholar 

  • Kondo H, Iwanaga T, Nakajima T (1982) Immunocytochemical study on the localization of neuron-specific enolase and S-100 protein in the carotid body of rats. Cell Tissue Res 227:291–295

    Article  CAS  PubMed  Google Scholar 

  • Kumar P, Prabhakar NR (2012) Peripheral chemoreceptors: function and plasticity of the carotid body. Compr Physiol 2:141–219

    Article  PubMed  PubMed Central  Google Scholar 

  • Kummer W, Gibbins IL, Stefan P, Kapoor V (1990) Catecholamines and catecholamine-synthesizing enzymes in guinea pig sensory ganglia. Cell Tissue Res 261:595–606

    Article  CAS  PubMed  Google Scholar 

  • Laidler P, Kay JM (1975) A quantitative morphological study of the carotid bodies of rats living at a stimulated altitude of 4300 metres. J Pathol 117:183–191

    Article  CAS  PubMed  Google Scholar 

  • Lazarov N, Atanasova D (2019) Morphological and new neurochemical aspects of the mammalian carotid body. Trakia J Sci 17(Suppl. 2):67–72

    Article  Google Scholar 

  • Lazarov N, Reindl S, Fischer F, Gratzl M (2009) Histaminergic and dopaminergic traits in the human carotid body. Respir Physiol Neurobiol 165:131–136

    Article  CAS  PubMed  Google Scholar 

  • Le Douarin N (1982) The neural crest. Cambridge University Press, London

    Google Scholar 

  • Leonard EM, Salman S, Nurse CA (2018) Sensory processing and integration at the carotid body tripartite synapse: neurotransmitter functions and effects of chronic hypoxia. Front Physiol 9:225

    Article  PubMed  PubMed Central  Google Scholar 

  • Lever JD, Boyd JD (1957) Osmiophilic granules in glomus cells of the rabbit carotid body. Nature 179:1082–1083

    Article  CAS  PubMed  Google Scholar 

  • Lever JD, Lewis PR, Boyd JD (1959) Observations on the fine structure and histochemistry of the carotid body in the cat and rabbit. J Anat 93:478–490

    CAS  PubMed  PubMed Central  Google Scholar 

  • McCloskey DI, Torrance RW (1971) Autoregulation of blood flow in the carotid body. Respir Physiol 13:23–35

    Article  CAS  PubMed  Google Scholar 

  • McDonald DM (1981) Peripheral chemoreceptors. Structure-function relationships of the carotid body. In: Hornbein TF (ed) Regulation of breathing. Dekker, New York, pp 105–319

    Google Scholar 

  • McDonald DM (1983) Morphology of the rat carotid sinus nerve. I. Course, connections, dimensions and ultrastructure. J Neurocytol 12:345–372

    Article  CAS  PubMed  Google Scholar 

  • McDonald DM, Haskell A (1984) Morphology of connections between arterioles and capillaries in the rat carotid body analysed by reconstructing serial sections. In: Pallot DJ (ed) The peripheral arterial chemoreceptors. Croom Helm, London, pp 195–206

    Google Scholar 

  • McDonald DM, Lurue DT (1983) The ultrastructure and connections of blood vessels supplying the rat carotid body and carotid sinus. J Neurocytol 12:117–153

    Article  CAS  PubMed  Google Scholar 

  • McDonald DM, Mitchell RA (1975) The innervation of glomus cells, ganglion cells and blood vessels in the rat carotid body: a quantitative ultrastructural study. J Neurocytol 4:177–230

    Article  Google Scholar 

  • Morgan M, Pack RJ, Howe A (1975) Nerve endings in rat carotid body. Cell Tissue Res 157:255–272

    Article  CAS  PubMed  Google Scholar 

  • Nurse CA (2005) Neurotransmission and neuromodulation in the chemosensory carotid body. Auton Neurosci 120:1–9

    Article  CAS  PubMed  Google Scholar 

  • Nurse CA (2014) Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors. J Physiol 592:3419–3426

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nurse CA, Leonard EM, Salman S (2018) Role of glial-like type II cells as paracrine modulators of carotid body chemoreception. Physiol Genomics 50:255–262

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ortega-Sáenz P, Pardal R, Levitsky K, Villadiego J, Muñoz-Manchado AB, Durán R, Bonilla-Henao V, Arias-Mayenco I, Sobrino V, Ordóñez A, Oliver M, Toledo-Aral JJ, López-Barneo J (2013) Cellular properties and chemosensory responses of the human carotid body. J Physiol 591:6157–6173

    Article  PubMed  PubMed Central  Google Scholar 

  • Pallot DJ (1987) The mammalian carotid body. Adv Anat Embryol Cell Biol 102:1–91

    Article  CAS  PubMed  Google Scholar 

  • Pardal R, Ortega-Sáenz P, Durán R, López-Barneo J (2007) Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body. Cell 131:364–377

    Article  CAS  PubMed  Google Scholar 

  • Pardal R, Ortega-Sáenz P, Durán R, Platero-Luengo A, López-Barneo J (2010) The carotid body, a neurogenic niche in the adult peripheral nervous system. Arch Ital Biol 148:95–105

    CAS  PubMed  Google Scholar 

  • Platero-Luengo A, González-Granero S, Durán R, Díaz-Castro B, Piruat JI, García-Verdugo JM, Pardal R, López-Barneo J (2014) An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia. Cell 156:291–303

    Article  CAS  PubMed  Google Scholar 

  • Porzionato A, Macchi V, Guidolin D, Parenti A, Ferrara SD, De Caro R (2005) Histopathology of carotid body in heroin addiction. Possible chemosensitive Impairment. . Histopathology 46:296–306

    Article  CAS  PubMed  Google Scholar 

  • Schäfer D, Seidl E, Acker H, Keller HP, Lübbers DW (1973) Arteriovenous anastomoses in the cat carotid body. Z Zellforsch Mikrosk Anat 142:515–524

    Article  PubMed  Google Scholar 

  • Schaper A (1892) Beiträge zur Histologie der Glandula carotica. Arch Mikrosk Anat 40:287–320

    Article  Google Scholar 

  • Schulz SA, Wöhler A, Beutner D, Angelov DN (2016) Microsurgical anatomy of the human carotid body (glomus caroticum): features of its detailed topography, syntopy and morphology. Ann Anat 204:106–113

    Article  PubMed  Google Scholar 

  • Seidl E (1975) On the morphology of the vascular system of the carotid body of cat and rabbit and its relations to type I cells. In: Purves MJ (ed) The peripheral arterial chemoreceptors. Cambridge University Press, London, pp 293–329

    Google Scholar 

  • Smith PG, Mills E (1976) Autoradiographic identification of the terminations of petrosal ganglion neurons in the cat carotid body. Brain Res 113:174–178

    Article  CAS  PubMed  Google Scholar 

  • Tse A, Yan L, Lee AK, Tse FW (2012) Autocrine and paracrine actions of ATP in rat carotid body. Can J Physiol Pharmacol 90:705–711

    Article  CAS  PubMed  Google Scholar 

  • Verna A (1975) Observations on the innervation of the carotid body of the rabbit. In: Purves MJ (ed) Peripheral arterial chemoreceptors. Cambridge University Press, Oxford, pp 75–97

    Google Scholar 

  • Verna A (1979) Ultrastructure of the carotid body in the mammals. Int Rev Cytol 60:271–330

    Article  CAS  PubMed  Google Scholar 

  • Verna A (1997) The mammalian carotid body: morphological data. In: González C (ed) The carotid body chemoreceptors. Landes Bioscience, Austin, pp 1–29

    Google Scholar 

  • Verna A, Barets A, Salat C (1984) Distribution of sympathetic nerve endings within the rabbit carotid body: a histochemical and ultrastructural study. J Neurocytol 13:849–865

    Article  CAS  PubMed  Google Scholar 

  • Wang Z-Y, Bisgard GE (2002) Chronic hypoxia-induced morphological and neurochemical changes in the carotid body. Microsc Res Tech 59:168–177

    Article  CAS  PubMed  Google Scholar 

  • Watzka M (1943) Die Paraganglien. Handbuch der mikroskopischen Anatomie, Band VI. Berlin, Springer

    Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy and Histology, Faculty of Medicine, Medical University of Sofia, Sofia, Bulgaria

    Nikolai E. Lazarov

  2. Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria

    Dimitrinka Y. Atanasova

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  1. Nikolai E. Lazarov
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  2. Dimitrinka Y. Atanasova
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Correspondence to Nikolai E. Lazarov .

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Lazarov, N.E., Atanasova, D.Y. (2023). General Morphology of the Mammalian Carotid Body. In: Morphofunctional and Neurochemical Aspects of the Mammalian Carotid Body. Advances in Anatomy, Embryology and Cell Biology, vol 237. Springer, Cham. https://doi.org/10.1007/978-3-031-44757-0_3

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