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Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy

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Vibrio spp. Infections

Abstract

Viruses of bacteria, i.e., bacteriophages (or phages for short), were discovered over a century ago and have played a major role as a model system for the establishment of the fields of microbial genetics and molecular biology. Despite the relative simplicity of phages, microbiologists are continually discovering new aspects of their biology including mechanisms for battling host defenses. In turn, novel mechanisms of host defense against phages are being discovered at a rapid clip. A deeper understanding of the arms race between bacteria and phages will continue to reveal novel molecular mechanisms and will be important for the rational design of phage-based prophylaxis and therapies to prevent and treat bacterial infections, respectively. Here we delve into the molecular interactions of Vibrio species and phages.

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Acknowledgments

This work was supported by Agencia Nacional de Investigación y Desarrollo, FONDECYT grants 11190158 (RMQ) and 11190049 (CAS-V) and by National Institutes of Health grants AI055058 (A.C.), AI147658 (A.C.).

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Correspondence to Cecilia A. Silva-Valenzuela .

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Molina-Quiroz, R.C., Camilli, A., Silva-Valenzuela, C.A. (2023). Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy. In: Almagro-Moreno, S., Pukatzki, S. (eds) Vibrio spp. Infections. Advances in Experimental Medicine and Biology, vol 1404. Springer, Cham. https://doi.org/10.1007/978-3-031-22997-8_8

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