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An Insight into Platelets at Older Age: Cellular and Clinical Perspectives

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Biochemistry and Cell Biology of Ageing: Part III Biomedical Science

Part of the book series: Subcellular Biochemistry ((SCBI,volume 102))

Abstract

Higher access to medical care, advanced diagnostic tools, and overall public health improvements have favored increased humans lifespan. With a growing proportion of older adults, the associated costs to care for ageing-associated conditions will continue to grow. This chapter highlights recent cellular and clinical evidence of platelets at an older age, from the hyperreactive phenotype associated with thrombosis to the well-known hallmarks of ageing identifiable in platelets and their potential functional implications on platelets at an older age. Therefore, it is imperative to understand platelets’ molecular and cellular mechanisms during ageing in health and disease. New knowledge will favor the development of new ways to prevent some of the age-associated complications where platelets are key players.

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Acknowledgments

This work was supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health under the award number K99HL156058-01 and the Hemophilia and Thrombosis Center from the University of Colorado School of Medicine. We thank Dr. Brandon McMahon from the Hematology Department of the University of Colorado, School of Medicine in the Anschutz Medical Campus.

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  1. Department of Pediatric Hematology, Oncology, and Bone Marrow Transplant, Aurora, CO, USA

    Guadalupe Rojas-Sanchez & Pavel Davizon-Castillo

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  1. Guadalupe Rojas-Sanchez
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  2. Pavel Davizon-Castillo
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Correspondence to Pavel Davizon-Castillo .

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  1. Institute for Molecular Physiology, University of Mainz, Mainz, Germany

    J. Robin Harris

  2. Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK

    Viktor I. Korolchuk

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Rojas-Sanchez, G., Davizon-Castillo, P. (2023). An Insight into Platelets at Older Age: Cellular and Clinical Perspectives. In: Harris, J.R., Korolchuk, V.I. (eds) Biochemistry and Cell Biology of Ageing: Part III Biomedical Science. Subcellular Biochemistry, vol 102. Springer, Cham. https://doi.org/10.1007/978-3-031-21410-3_13

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