Abstract
An automated pipeline is developed for the serial assessment of renal calculi using computed tomography (CT) scans obtained at multiple time points. This retrospective study included 722 scans from 330 patients chosen from 8544 asymptomatic patients who underwent two or more CTC (CT colonography) or non-enhanced abdominal CT scans between 2004 and 2016 at a single medical center. A pre-trained deep learning (DL) model was used to segment the kidneys and the calculi on the CT scans at each time point. Based on the output of the DL, 330 patients were identified as having a stone candidate on at least one time point. Then, for every patient in this group, the kidneys from different time points were registered to each other, and the calculi present at multiple time points were matched to each other using proximity on the registered scans. The automated pipeline was validated by having a blinded radiologist assess the changes manually. New graph-based metrics are introduced in order to evaluate the performance of our pipeline. Our method shows high fidelity in tracking changes in renal calculi over multiple time points.
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References
Smith, R.C., et al.: Acute flank pain: comparison of non-contrast-enhanced CT and intravenous urography. Radiology 194, 789–794 (1995)
Preminger, G.M., Vieweg, J., Leder, R.A., Nelson, R.C.: Urolithiasis: detection and management with unenhanced spiral CT–a urologic perspective. Radiology 207, 308–309 (1998)
Rajapaksa, R.C., Macari, M., Bini, E.J.: Prevalence and impact of extracolonic findings in patients undergoing CT colonography. J. Clin. Gastroenterol. 38, 767–771 (2004)
Hara, A.K., Johnson, C.D., MacCarty, R.L., Welch, T.J.: Incidental extracolonic findings at CT colonography. Radiology 215, 353–357 (2000)
Boyce, C.J., Pickhardt, P.J., Lawrence, E.M., Kim, D.H., Bruce, R.J.: Prevalence of urolithiasis in asymptomatic adults: objective determination using low dose noncontrast computerized tomography. J. Urol. 183, 1017–1021 (2010)
Kang, H.W., et al.: Natural history of asymptomatic renal stones and prediction of stone related events. J. Urol 189, 1740–1746 (2013)
Koh, L.T., Ng, F.C., Ng, K.K.: Outcomes of long-term follow-up of patients with conservative management of asymptomatic renal calculi. BJU Int. 109, 622–625 (2012)
Curhan, G.C.: Epidemiology of stone disease. Urol. Clin. North Am. 34, 287–293 (2007)
Pearle, M.S., Calhoun, E.A., Curhan, G.C.: Urologic diseases of America, P.: urologic diseases in America project: urolithiasis. J. Urol. 173, 848–857 (2005)
Gluecker, T.M., et al.: Extracolonic findings at CT colonography: evaluation of prevalence and cost in a screening population. Gastroenterology 124, 911–916 (2003)
Kampa, R.J., Ghani, K.R., Wahed, S., Patel, U., Anson, K.M.: Size matters: a survey of how urinary-tract stones are measured in the UK. J. Endourol. 19, 856–860 (2005)
Lidén, M., Andersson, T., Geijer, H.: Making renal stones change size—impact of CT image post processing and reader variability. Eur. Radiol. 21, 2218–2225 (2011)
Acosta, J.N., Falcone, G.J., Rajpurkar, P.: The need for medical artificial intelligence that incorporates prior images. Radiology, 212830
Elton, D.C., Turkbey, E.B., Pickhardt, P.J., Summers, R.M.: A deep learning system for automated kidney stone detection and volumetric segmentation on noncontrast CT scans. Med. Phy. 49, 2545–2554 (2022)
Bernardin, K., Stiefelhagen, R.: Evaluating multiple object tracking performance: the clear MOT metrics. EURASIP J. Image Video Process. 2008(1), 1 (2008). https://doi.org/10.1155/2008/246309
Pickhardt, P.J., et al.: Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. N Engl J Med 349, 2191–2200 (2003)
Yushkevich, P.A., Pluta, J., Wang, H., Wisse, L.E.M., Das, S., Wolk, D.: IC-P-174: Fast automatic segmentation of hippocampal subfields and medial temporal lobe subregions in 3 tesla and 7 tesla T2-weighted MRI. Alzheimers Dement. 12, P126–P127 (2016)
Cai, J., et al.: Deep lesion tracker: monitoring lesions in 4d longitudinal imaging studies. In: 2021 IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR), IEEE (2021)
Yan, K., Wang, X., Lu, L., Summers, R.M.: DeepLesion: automated mining of large-scale lesion annotations and universal lesion detection with deep learning. J. Med. Imaging 5, 1 (2018)
Acknowledgements
This research was supported by the Intramural Research Program of the National Institutes of Health, Clinical Center, and we utilized the computational resources of the National Institutes of Health high-performance computing Biowulf cluster.
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Mukherjee, P., Lee, S., Pickhardt, P.J., Summers, R.M. (2022). Automated Assessment of Renal Calculi in Serial Computed Tomography Scans. In: Wu, S., Shabestari, B., Xing, L. (eds) Applications of Medical Artificial Intelligence. AMAI 2022. Lecture Notes in Computer Science, vol 13540. Springer, Cham. https://doi.org/10.1007/978-3-031-17721-7_5
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DOI: https://doi.org/10.1007/978-3-031-17721-7_5
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