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Image Quality Classification for Automated Visual Evaluation of Cervical Precancer

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Medical Image Learning with Limited and Noisy Data (MILLanD 2022)

Abstract

Image quality control is a critical element in the process of data collection and cleaning. Both manual and automated analyses alike are adversely impacted by bad quality data. There are several factors that can degrade image quality and, correspondingly, there are many approaches to mitigate their negative impact. In this paper, we address image quality control toward our goal of improving the performance of automated visual evaluation (AVE) for cervical precancer screening. Specifically, we report efforts made toward classifying images into four quality categories (“unusable”, “unsatisfactory”, “limited”, and “evaluable”) and improving the quality classification performance by automatically identifying mislabeled and overly ambiguous images. The proposed new deep learning ensemble framework is an integration of several networks that consists of three main components: cervix detection, mislabel identification, and quality classification. We evaluated our method using a large dataset that comprises 87,420 images obtained from 14,183 patients through several cervical cancer studies conducted by different providers using different imaging devices in different geographic regions worldwide. The proposed ensemble approach achieved higher performance than the baseline approaches.

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References

  1. Jeronimo, J., Massad, L.S., Castle, P.E., Wacholder, S., Schiffman, M.: Interobserver agreement in the evaluation of digitized cervical images. Obstet. Gynecol. 110, 833–840 (2007)

    Article  Google Scholar 

  2. Hu, L., Bell, D., Antani, S., Xue, Z., Yu, K., Horning, M.P., et al.: An observational study of deep learning and automated evaluation of cervical images for cancer screening. J. Natl. Cancer Inst. (JNCI) 111(9), 923–932 (2019)

    Article  Google Scholar 

  3. Xue, Z., Novetsky, A.P., Einstein, M.H., et al.: A demonstration of automated visual evaluation of cervical images taken with a smartphone camera. Int. J. Cancer (2020). https://doi.org/10.1002/ijc.33029

    Article  Google Scholar 

  4. Desai, K.T., et al.: The development of “automated visual evaluation” for cervical cancer screening: the promise and challenges in adapting deep-learning for clinical testing: interdisciplinary principles of automated visual evaluation in cervical screening. Int. J. Cancer. 150(5), 741–752 (2022). https://doi.org/10.1002/ijc.33879

    Article  Google Scholar 

  5. Guo, P., et al.: Ensemble deep learning for cervix image selection toward improving reliability in automated cervical precancer screening. Diagnostics 10(7), 451 (2020)

    Article  Google Scholar 

  6. Xue, Z., et al.: Cleaning highly unbalanced multisource image dataset for quality control in cervical precancer screening. In: Santosh, K., Hegadi, R., Pal, U. (eds.) Recent Trends in Image Processing and Pattern Recognition, pp. 3–13. Springer, Cham (2021). https://doi.org/10.1007/978-3-031-07005-1_1

    Chapter  Google Scholar 

  7. Guo, P., Singh, S., Xue, Z., Long, L.R., Antani, S.: Deep learning for assessing image focus for automated cervical cancer screening. In: IEEE EMBS International Conference on Biomedical & Health Informatics (BHI) (2019). https://doi.org/10.1109/BHI.2019.8834495

  8. Ganesan, P., Xue, Z., Singh, S., Long, L.R., Ghoraani, B., Antani, S.: Performance evaluation of a generative adversarial network for deblurring mobile-phone cervical images. In: Proceedings of IEEE Engineering in Medicine and Biology Conference (EMBC), Berlin, Germany, pp. 4487–4490 (2019)

    Google Scholar 

  9. Xue, Z., Angara, S., Levitz, D., Antani, S.: Analysis of digital noise and reduction methods on classifiers used in automated visual evaluation in cervical cancer screening. Proc. SPIE Int. Soc. Opt. Eng. 11950, 1195008 (2022). https://doi.org/10.1117/12.2610235

  10. Shen, Y., Sanghavi, S.: Learning with bad training data via iterative trimmed loss minimization. In: ICML (2019)

    Google Scholar 

  11. Pleiss, G., Zhang, T., Elenberg, E., Weinberger, K.Q.: Identifying mislabeled data using the area under the margin ranking. In: Proceedings of the 34th International Conference on Neural Information Processing Systems (NeurIPS), pp. 17044–17056. Curran Associates Inc., Red Hook, Article 1430 (2020)

    Google Scholar 

  12. Zhang, Z., Sabuncu, M.R.: Generalized cross entropy loss for training deep neural networks with noisy labels. In: Proceedings of the 32th International Conference on Neural Information Processing Systems (NeurIPS) (2018)

    Google Scholar 

  13. Patrini, G., Rozza, A., Krishna Menon, A., Nock, R., Qu, L.: Making deep neural networks robust to label noise: a loss correction approach. In: Conference on Computer Vision and Pattern Recognition (CVPR) (2017)

    Google Scholar 

  14. Northcutt, C., Jiang, L., Chuang, I.: Confident Learning: Estimating Uncertainty in Dataset Labels. J. Artif. Intell. 70, 1373–1411 (2021). https://doi.org/10.1613/jair.1.12125

    Article  MathSciNet  MATH  Google Scholar 

  15. Desai, K.T., et al.: Design and feasibility of a novel program of cervical screening in Nigeria: self-sampled HPV testing paired with visual triage. Infect. Agent Cancer 15(60) (2020). https://doi.org/10.1186/s13027-020-00324-5

  16. Wang, S.S., et al.: Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants. Cancer Epidemiol Biomarkers Prev. 18(1), 113–120 (2009). https://doi.org/10.1158/1055-9965.EPI-08-0591

    Article  Google Scholar 

  17. Lin, T., Goyal, P., Girshick, R., He, K., Dollar, P.: Focal loss for dense object detection. IEEE Trans. Pattern Anal. Mach. Intell. 42(02), 318–327 (2020)

    Article  Google Scholar 

  18. Herrero, R., Wacholder, S., Rodriguez, A.C., et al.: Prevention of persistent human papillomavirus infection by an HPV16/18 vaccine: a community-based randomized clinical trial in Guanacaste, Costa Rica. Cancer Discov. 1(5), 408–419 (2011)

    Google Scholar 

  19. Zhang, H., et al.: ResNeSt: split-attention networks. https://arxiv.org/abs/2004.08955

  20. Liu, Z., et al.: Swin transformer: hierarchical vision transformer using shifted windows. In: 2021 IEEE/CVF International Conference on Computer Vision (ICCV), Montreal, QC, Canada, pp. 9992–10002 (2021)

    Google Scholar 

  21. Northcutt, C., Athalye, A., Mueller, J.: Pervasive label errors in test sets destabilize machine learning benchmarks. In: The 35th Conference on Neural Information Processing Systems (NeuIPS) (2021)

    Google Scholar 

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Acknowledgement

This research was supported by the Intramural Research Program of the National Library of Medicine (NLM) and the Intramural Research Program of the National Cancer Institute (NCI). Both NLM and NCI are part of the National Institutes of Health (NIH). The NET study was supported partly by Global Good. The authors also want to thank Farideh Almani at NCI for her help.

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Correspondence to Zhiyun Xue .

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Appendix

Appendix

Table 4. The device and PI of each dataset
Table 5. Number of images in each dataset in each quality category
Fig. 3.
figure 3

Examples of images in each quality category.

Fig. 4.
figure 4

The classification confusion matrix of the test set

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Xue, Z. et al. (2022). Image Quality Classification for Automated Visual Evaluation of Cervical Precancer. In: Zamzmi, G., Antani, S., Bagci, U., Linguraru, M.G., Rajaraman, S., Xue, Z. (eds) Medical Image Learning with Limited and Noisy Data. MILLanD 2022. Lecture Notes in Computer Science, vol 13559. Springer, Cham. https://doi.org/10.1007/978-3-031-16760-7_20

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  • DOI: https://doi.org/10.1007/978-3-031-16760-7_20

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