Abstract
Bisphenol A (BPA) is an endocrine-disrupting chemical that is capable of mimicking, antagonizing, and interfering with the normal biological functioning of the endocrine system. BPA is used in diverse industries, hence its vast sources of exposure. Although the half-life of BPA is relatively short (<24 hours), studies have reported its detection in the urine of different populations. It, therefore, became important to investigate its effect on general health, including male reproductive health. The adverse effects of BPA on male fertility have been evaluated and reported from both in vivo and in vitro studies. Up to date, reports from randomized controlled trials remain controversial, as some revealed decreased sperm quality, sperm concentration, and total sperm count, while others reported that no adverse effect was seen after exposure. Findings from animal model studies and in vitro experiments have shown that exposure to BPA led to a reduction in sperm quality and increased sperm DNA fragmentation, and some even revealed altered expression of the gene that encodes gonadotropin-releasing hormone. This shows that BPA not only may adversely affect male fertility by acting as an endocrine disruptor but also can potentially impact male fertility via its possible contribution to oxidative stress. Therefore, this book chapter aims to identify and elucidate the effect of BPA exposure on male fertility, and to as well illustrate the mechanisms through which this occurs, while emphasizing the role of oxidative stress as a potential pathway.
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References
Acconcia F, Pallottini V, Marino M. Molecular mechanisms of action of BPA. Dose-Response. 2015; https://doi.org/10.1177/1559325815610582.
Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril. 2003;79:829–43.
Agarwal A, Virk G, Ong C, du Plessis SS. Effect of oxidative stress on male reproduction. World J Mens Health. 2014;32:1–17.
Agarwal A, Sharma R, Roychoudhury S, Du Plessis S, Sabanegh E. MiOXSYS: a novel method of measuring oxidation reduction potential in semen and seminal plasma. Fertil Steril. 2016; https://doi.org/10.1016/j.fertnstert.2016.05.013.
Aitken RJ. Nitroblue tetrazolium (NBT) assay. Reprod Biomed Online. 2018; https://doi.org/10.1016/j.rbmo.2017.09.005.
Alahmar A. Role of oxidative stress in male infertility: an updated review. J Hum Reprod Sci. 2019;12:4–18.
Ali SS, Ahsan H, Zia MK, Siddiqui T, Khan FH. Understanding oxidants and antioxidants: classical team with new players. J Food Biochem. 2020;44:e13145.
Babakhanzadeh E, Nazari M, Ghasemifar S, Khodadadian A. Some of the factors involved in male infertility: a prospective review. Int J Gen Med. 2020;13:29–41.
Barbonetti A, Castellini C, Di Giammarco N, Santilli G, Francavilla S, Francavilla F. In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative/apoptotic mitochondrial dysfunction. Reprod Toxicol. 2016;66:61–7.
Benson TE, Gaml-Sørensen A, Ernst A, et al. Urinary bisphenol a, f and s levels and semen quality in young adult danish men. Int J Environ Res Public Health. 2021;18:1–12.
Castellini C, Totaro M, Parisi A, D’Andrea S, Lucente L, Cordeschi G, Francavilla S, Francavilla F, Barbonetti A. Bisphenol a and male fertility: myths and realities. Front Endocrinol (Lausanne). 2020; https://doi.org/10.3389/fendo.2020.00353.
Chiang C, Mahalingam S, Flaws JA. Environmental contaminants affecting fertility and somatic health. Semin Reprod Med. 2017;35:241–9.
Dabbous Z, Atkin SL. Hyperprolactinaemia in male infertility: Clinical case scenarios. Arab J Urol. 2018;16:44–52.
Ding J, Shang X, Zhang Z, Jing H, Shao J, Fei Q, Rayburn ER, Li H. FDA-approved medications that impair human spermatogenesis. Oncotarget. 2017;8:10714–25.
Du Plessis SS, Agarwal A, Halabi J, Tvrda E. Contemporary evidence on the physiological role of reactive oxygen species in human sperm function. J Assist Reprod Genet. 2015;32:509–20.
Emedicine.medscape.com. Follicle-stimulating hormone abnormalities: practice essentials, pathophysiology, epidemiology. In: Online; 2021. https://emedicine.medscape.com/article/118810-overview#a1. Accessed 22 Oct 2021.
Gandhi J, Hernandez RJ, Chen A, Smith NL, Sheynkin YR, Joshi G, Khan SA. Impaired hypothalamic-pituitary-testicular axis activity, spermatogenesis, and sperm function promote infertility in males with lead poisoning. Zygote. 2017;25:103–10.
Gassman NR. Induction of oxidative stress by bisphenol a and its pleiotropic effects. Environ Mol Mutagen. 2017;58:60–71.
Jang TH. Cryopreservation and its clinical applications | Elsevier Enhanced Reader. Integr Med Res. 2017;6:12–8.
Janosek-Albright KJC, Schlegel PN, Dabaja AA. Testis sperm extraction. Asian J Urol. 2015;2:79–84.
Jia J, Xu H, Chen C, Zhang X, Zhang X, Li W, Ma J. Quantitative proteomic analysis of mouse testis uncovers cellular pathways associated with bisphenol a (BPA)-induced male infertility. Gen Physiol Biophys. 2020;39:331–41.
Klein EA, Thompson IM, Tangen CM, et al. Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT). JAMA – J Am Med Assoc. 2011;306:1549–56.
Kohno M. Applications of electron spin resonance spectrometry for reactive oxygen species and reactive nitrogen species research. J Clin Biochem Nutr. 2010; https://doi.org/10.3164/jcbn.10-13R.
Komarowska MD, Hermanowicz A, Czyzewska U, Milewski R, Matuszczak E, Miltyk W, Debek W. Serum bisphenol a level in boys with cryptorchidism: a step to male infertility? Int J Endocrinol. 2015;2015:973154.
Konieczna A, Rutkowska A, Rachoń D. Health risk of exposure to Bisphenol A (BPA). Rocz Państwowego Zakładu Hig. 2015;66:5–11.
Krzastek SC, Farhi J, Gray M, Smith RP. Impact of environmental toxin exposure on male fertility potential. Transl Androl Urol. 2021;9:2797–813.
Kumar S, Sharma A. Cadmium toxicity: effects on human reproduction and fertility. Rev Environ Health. 2019; https://doi.org/10.1515/reveh-2019-0016.
Li YR, Trush M. Defining ROS in biology and medicine. React Oxyg Species. 2016;1:9–21.
Li C, Zhang L, Ma T, et al. Bisphenol a attenuates testosterone production in Leydig cells via the inhibition of NR1D1 signaling. Chemosphere. 2021; https://doi.org/10.1016/j.chemosphere.2020.128020.
Liang X, Yin N, Liang S, Yang R, Liu S, Lu Y, Jiang L, Zhou Q, Jiang G, Faiola F. Bisphenol a and several derivatives exert neural toxicity in human neuron-like cells by decreasing neurite length. Food Chem Toxicol. 2020; https://doi.org/10.1016/j.fct.2019.111015.
Liu X, Miao M, Zhou Z, Gao E, Chen J, Wang J, Sun F, Yuan W, Li DK. Exposure to bisphenol-A and reproductive hormones among male adults. Environ Toxicol Pharmacol. 2015;39:934–41.
Liu XX, Wang ZX, Liu FJ. Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice. Chemosphere. 2021;262:127880.
Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev. 2010;4:118–26.
Loganathan SN, Kannan K. Occurrence of bisphenol a in indoor dust from two locations in the Eastern United States and implications for human exposures. Arch Environ Contam Toxicol. 2011;61:68–73.
Martin-Hidalgo D, Bragado MJ, Batista AR, Oliveira PF, Alves MG. Antioxidants and male fertility: from molecular studies to clinical evidence. Antioxidants. 2019;8:89.
Masuyama H, Hiramatsu Y. Involvement of suppressor for Gal 1 in the ubiquitin/proteasome-mediated degradation of estrogen receptors. J Biol Chem. 2004; https://doi.org/10.1074/jbc.M312762200.
Melgarejo M, Mendiola J, Koch HM, Moñino-García M, Noguera-Velasco JA, Torres-Cantero AM. Associations between urinary organophosphate pesticide metabolite levels and reproductive parameters in men from an infertility clinic. Environ Res. 2015; https://doi.org/10.1016/j.envres.2015.01.004.
Meli R, Monnolo A, Annunziata C, Pirozzi C, Ferrante MC. Oxidative stress and BPA toxicity: an antioxidant approach for male and female reproductive dysfunction. Antioxidants. 2020;9:405.
Mima M, Greenwald D, Ohlander S. Environmental toxins and male fertility. Curr Urol Rep. 2018; https://doi.org/10.1007/s11934-018-0804-1.
Mínguez-Alarcón L, Bellavia A, Gaskins AJ, Chavarro JE, Ford JB, Souter I, Calafat AM, Hauser R, Williams PL. Paternal mixtures of urinary concentrations of phthalate metabolites, bisphenol A and parabens in relation to pregnancy outcomes among couples attending a fertility center. Environ Int. 2021; https://doi.org/10.1016/j.envint.2020.106171.
Ni K, Steger K, Yang H, Wang H, Hu K, Zhang T, Chen B. A comprehensive investigation of sperm DNA damage and oxidative stress injury in infertile patients with subclinical, normozoospermic, and astheno/oligozoospermic clinical varicocoele. Andrology. 2016;4:816–24.
Ou B, Hampsch-Woodill M, Prior RL. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem. 2001; https://doi.org/10.1021/jf010586o.
Pahune PP, Choudhari AR, Muley PA. The total antioxidant power of semen and its correlation with the fertility potential of human male subjects. J Clin Diagnostic Res. 2013;7:991–5.
Pallotti F, Pelloni M, Gianfrilli D, Lenzi A, Lombardo F, Paoli D. Mechanisms of testicular disruption from exposure to bisphenol a and phtalates. J Clin Med. 2020;9:471.
Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A. Oxidative stress: harms and benefits for human health. Oxidative Med Cell Longev. 2017;2017:8416763.
plasticstoday. BPA alternatives also pose health risks, study finds. In: Online; 2019. ps://www.plasticstoday.com/medical/bpa-alternatives-also-pose-health-risks-study-finds. Accessed 21 Oct 2021.
Rahman MS, Pang WK, Ryu DY, Park YJ, Ryu BY, Pang MG. Multigenerational impacts of gestational bisphenol a exposure on the sperm function and fertility of male mice. J Hazard Mater. 2021;416:125791.
Rana SVS. Perspectives in endocrine toxicity of heavy metals - a review. Biol Trace Elem Res. 2014; https://doi.org/10.1007/s12011-014-0023-7.
Rezaee-Tazangi F, Zeidooni L, Rafiee Z, Fakhredini F, Kalantari H, Alidadi H, Khorsandi L. Taurine effects on bisphenol a-induced oxidative stress in the mouse testicular mitochondria and sperm motility. J Bras Reprod Assist. 2020;24:428–35.
Rochester JR. Bisphenol a and human health: a review of the literature. Reprod Toxicol. 2013;42:132–55.
Santiago J, Silva JV, Santos MAS, Fardilha M. Fighting bisphenol a-induced male infertility: the power of antioxidants. Antioxidants. 2021;10:1–22.
Schlegel PN. Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision. Hum Reprod. 1999;14:131–5.
Schulster M, Bernie AM, Ramasamy R. The role of estradiol in male reproductive function. Asian J Androl. 2016;18:435–40.
Sharifi-Rad M, Anil Kumar NV, Zucca P, et al. Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases. Front Physiol. 2020;11:694.
Sharma A, Mollier J, Brocklesby RWK, Caves C, Jayasena CN, Minhas S. Endocrine-disrupting chemicals and male reproductive health. Reprod Med Biol. 2020;19:243–53.
Smits RM, Mackenzie-Proctor R, Yazdani A, Stankiewicz MT, Jordan V, Showell MG. Antioxidants for male subfertility. Cochrane Database Syst Rev. 2019; https://doi.org/10.1002/14651858.CD007411.pub4.
Stone WL, Pham TMS. Biochemistry, antioxidants. Online. StatPearls Publishing; 2021.
Tremellen K. Oxidative stress and male infertility: a clinical perspective. Stud Men Heal Fertil. 2012;14:325–53.
Twigg J, Irvine DS, Houston P, Fulton N, Michael L, Aitken RJ. Iatrogenic DNA damage induced in human spermatozoa during sperm preparation: protective significance of seminal plasma. Mol Hum Reprod. 1998;4:439–45.
Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol a (BPA). Reprod Toxicol. 2007;24:139–77.
Vander Borght M, Wyns C. Fertility and infertility: definition and epidemiology. Clin Biochem. 2018; https://doi.org/10.1016/j.clinbiochem.2018.03.012.
Vitku J, Sosvorova L, Chlupacova T, Hampl R, Hill M, Sobotka V, Heracek J, Bicikova M, Starka L. Differences in bisphenol a and estrogen levels in the plasma and seminal plasma of men with different degrees of infertility. Physiol Res. 2015;64:S303–11.
Wang C, Qi S, Liu C, Yang A, Fu W, Quan C, Duan P, Yu T, Yang K. Mitochondrial dysfunction and Ca2+ overload in injured sertoli cells exposed to bisphenol a. Environ Toxicol. 2017;32:823–31.
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This project was partially supported by the Al Jalila Foundation.
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Mubarak, M., Omolaoye, T.S., Al Smady, M.N., Zaki, M.N., du Plessis, S.S. (2022). Bisphenol A and Male Infertility: Role of Oxidative Stress. In: Roychoudhury, S., Kesari, K.K. (eds) Oxidative Stress and Toxicity in Reproductive Biology and Medicine. Advances in Experimental Medicine and Biology, vol 1391. Springer, Cham. https://doi.org/10.1007/978-3-031-12966-7_8
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