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Pathological Role of Reactive Oxygen Species on Female Reproduction

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Oxidative Stress and Toxicity in Reproductive Biology and Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1391))

Abstract

Oxidative stress (OS), a clinical predicament characterized by a shift in homeostatic imbalance among prooxidant molecules embracing reactive oxygen species (ROS) and reactive nitrogen species (RNS), along with antioxidant defenses, has been established to play an indispensable part in the pathophysiology of subfertility in both human males and females. ROS are highly reactive oxidizing by-products generated during critical oxygen-consuming processes or aerobic metabolism. A healthy body system has its own course of action to maintain the equilibrium between prooxidants and antioxidants with an efficient defense system to fight against ROS. But when ROS production crosses its threshold, the disturbance in homeostatic balance results in OS. Besides their noxious effects, literature studies have depicted that controlled and adequate ROS concentrations exert physiologic functions, especially that gynecologic OS is an important mediator of conception in females. Yet the impact of ROS on oocytes and reproductive functions still needs a strong attestation for further analysis because the disruption in prooxidant and antioxidant balance leads to abrupt ROS generation initiating multiple reproductive diseases such as polycystic ovary syndrome (PCOS), endometriosis, and unexplained infertility in addition to other impediments in pregnancy such as recurrent pregnancy loss, spontaneous abortion, and preeclampsia. The current article elucidates the skeptical state of affairs created by ROS that influences female fertility.

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  1. Lisa Goutami & Soumya Ranjan Jena

    Present address: Department of Zoology, Redox Biology & Proteomics Laboratory, School of Life Sciences and Centre for Excellence in Environment and Public Health, Ravenshaw University, Cuttack, Odisha, India

  2. Amrita Swain

    Present address: Department of Zoology, Biochemistry & Molecular Biology Laboratory, School of Life Sciences, Bhubaneswar, Odisha, India

Authors and Affiliations

  1. Department of Zoology, Redox Biology & Proteomics Laboratory, School of Life Sciences and Centre for Excellence in Environment and Public Health, Ravenshaw University, Cuttack, Odisha, India

    Luna Samanta

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  1. Lisa Goutami
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  1. Department of Life Science and Bioinformatics, Assam University, Silchar, India

    Shubhadeep Roychoudhury

  2. Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, ESPOO, Finland

    Kavindra Kumar Kesari

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Goutami, L., Jena, S.R., Swain, A., Samanta, L. (2022). Pathological Role of Reactive Oxygen Species on Female Reproduction. In: Roychoudhury, S., Kesari, K.K. (eds) Oxidative Stress and Toxicity in Reproductive Biology and Medicine. Advances in Experimental Medicine and Biology, vol 1391. Springer, Cham. https://doi.org/10.1007/978-3-031-12966-7_12

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