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Epigallocatechin-3-Gallate (EGCG), An Alternative to Extenuate Occupational Risk Factors Outcomes?—An Interventional Study

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Occupational and Environmental Safety and Health IV

Part of the book series: Studies in Systems, Decision and Control ((SSDC,volume 449))

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Abstract

Introduction: Occupational risk factors are major players for increased risk of cardiovascular diseases and cancer. Studies support a protective role of Epigallocatechin-3-gallate (EGCG) in disease onset, with associated antioxidant properties and reactive oxygen species production. We aimed to evaluate the in vivo effects of EGCG intake on cardiovascular risk factors, DNA damage and oxidative DNA damage. Methods: Voluntaries were enrolled in this interventional study with safeguard of all ethical considerations. Peripheral blood was collected at the beginning and after 90 days of 225 mg EGCG ingestion per day. Lipid profile and liver function parameters were assessed using colorimetric methods. Vitamins A and E in serum were quantified by HPLC–DAD. DNA damage and oxidative DNA damage were assessed through comet assay. Results: Vitamin A, as well as the lipid profile and liver function parameters, were not affected by EGCG intake, whereas serum levels of vitamin E, DNA damage and DNA oxidative damage increased after EGCG consumption. Discussion/Conclusions: EGCG induce low-level oxidative stress which may trigger protective antioxidant systems associated with vitamin E. Further research is crucial to understand the extent of EGCG effects and its potential as an alternative to extenuate occupational risk factors outcomes.

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Acknowledgements

H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020 and the financial and institutional support of Health & Technology Research Center, ESTeSL- Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa.

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Authors and Affiliations

  1. Health and Technology Research Center, Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisboa, Portugal

    Carina Ladeira & Edna Ribeiro

  2. Centro de Investigação e Estudos em Saúde Pública, Escola Nacional de Saúde Pública, Universidade Nova de Lisboa, Lisboa, Portugal

    Carina Ladeira

  3. Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisboa, Portugal

    Mário Pádua

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  1. Carina Ladeira
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  2. Mário Pádua
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  3. Edna Ribeiro
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Correspondence to Edna Ribeiro .

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Editors and Affiliations

  1. Department of Production and Systems, School of Engineering, University of Minho, Guimarães, Portugal

    Pedro M. Arezes

  2. Department of Mining Engineering, Faculty of Engineering, University of Porto, Porto, Portugal

    J. Santos Baptista

  3. Faculty of Human Kinetics, University of Lisbon, Lisbon, Portugal

    Rui B. Melo

  4. Department of Mining Engineering, Faculty of Engineering, University of Porto, Porto, Portugal

    Jacqueline Castelo Branco

  5. Department of Production and Systems, School of Engineering, University of Minho, Guimarães, Portugal

    Paula Carneiro

  6. School of Engineering, University of Minho, Guimarães, Portugal

    Ana Colim

  7. Department of Production and Systems, School of Engineering, University of Minho, Guimarães, Portugal

    Nélson Costa

  8. School of Engineering, University of Minho, Guimarães, Portugal

    Susana Costa

  9. Department of Mining Engineering, Faculty of Engineering, University of Porto, Porto, Portugal

    J. Duarte

  10. Department of Mining Engineering, Faculty of Engineering, University of Porto, Porto, Portugal

    J. C. Guedes

  11. Department of Mining Engineering, Faculty of Engineering, University of Porto, Porto, Portugal

    Gonçalo Perestrelo

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Ladeira, C., Pádua, M., Ribeiro, E. (2023). Epigallocatechin-3-Gallate (EGCG), An Alternative to Extenuate Occupational Risk Factors Outcomes?—An Interventional Study. In: Arezes, P.M., et al. Occupational and Environmental Safety and Health IV. Studies in Systems, Decision and Control, vol 449. Springer, Cham. https://doi.org/10.1007/978-3-031-12547-8_34

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