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Gut Microbiota and Chronic Kidney Disease

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Innovations in Nephrology

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Abstract

The human microbiome, a term derived from the Greek mikros (small) and Latin, bio (life) and oma (group or mass), is characterized by a set of microorganisms, their genomes, and the environmental conditions present in tissues and different parts of the human body [4]. There is extensive search to understand the human microbiome, its metabolites, its action on the host, and the importance of the complexity of these relationships in health and disease. Thus, advances in high-throughput sequencing methods have paved the way for decoding bacterial genomes from different parts of the human body, a fundamental basis for microbiome analysis. Besides, the use of new technologies, especially those related to “omics” technologies—genomics, proteomics, metabolomics, and others [5]. There is a connection between intestines and kidneys that can be classified into metabolic and immunological pathways. In the metabolic pathway, mediated by metabolites produced by the gut microbiota, an inadequate diet is the possible inducer, resulting in a high production and accumulation of toxic substances, called uremic toxins (UTs) in the intestinal environment, such as indoxyl sulfate (IS) and para-cresyl sulfate (PCS).

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Author information

Authors and Affiliations

  1. Department of Nutrition, School of Nutrition, University of Fortaleza, Fortaleza, CE, Brazil

    Antonio Augusto Ferreira Carioca

  2. Postgraduate Program in Nutrition and Health, Ceara State University, Fortaleza, CE, Brazil

    Suiani da Silva Sales & Bárbara Rebeca Cordeiro de Melo

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  1. Antonio Augusto Ferreira Carioca
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  2. Suiani da Silva Sales
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  3. Bárbara Rebeca Cordeiro de Melo
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Correspondence to Antonio Augusto Ferreira Carioca .

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Editors and Affiliations

  1. School of Medicine, University of Fortaleza, Fortaleza, Ceará, Brazil

    Geraldo Bezerra da Silva Junior

  2. Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan

    Masaomi Nangaku

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Carioca, A.A.F., da Silva Sales, S., de Melo, B.R.C. (2022). Gut Microbiota and Chronic Kidney Disease. In: Bezerra da Silva Junior, G., Nangaku, M. (eds) Innovations in Nephrology. Springer, Cham. https://doi.org/10.1007/978-3-031-11570-7_6

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  • DOI: https://doi.org/10.1007/978-3-031-11570-7_6

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