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Herpesviruses in Periodontitis: An Umbrella Review

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Periodontitis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1373))

Abstract

Background: Despite numerous studies indicating a high prevalence of herpesviruses in both apical and marginal periodontitis samples, their exact role in the pathogenesis of a periodontal disease is still unclear.

Objective: This umbrella review aimed to summarize data on herpesviruses detection in marginal periodontitis (MP) and apical periodontitis of endodontic origin (APEO) samples.

Methods: The study protocol has been drafted a priori and registered to the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42020215922). The literature search was conducted using the following electronic databases: Clarivate Analytics’ Web of Science, Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to October 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between the occurrence of herpesviruses and different forms of periodontal diseases were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction, and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews).

Results: Six systematic reviews were included in the current review. One was graded as high quality, another one was graded as moderate quality, whereas the other four were graded as critically low-quality reviews. The presence of herpesviruses in subgingival samples was associated with an increased risk of MP, supported by the corresponding meta-analyses. Although the association was strong (OR > 3.0), the confidence intervals were wide, heterogeneity was significant, and studies were of small sample size. In addition, publication bias was detected. Contrary, data from systematic reviews that assessed APEO and herpesviruses did not show any significant associations.

Conclusions: Low-quality studies with high uncertainty suggest a strong association between herpesviruses and MP, but not with APEO.

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Abbreviations

AgP:

Aggressive periodontitis

AMSTAR:

Assessment of multiple systematic reviews

APEO:

Apical periodontitis of endodontic origin

BZLF-1:

BamHI fragment Z leftward open reading frame 1

CI:

Confidence interval

CP:

Chronic periodontitis

DEEP:

DART-European E-theses portal

EBV :

Epstein-Barr virus

EThOS:

Opening access to UK theses

HCMV :

Human cytomegalovirus

HSV :

Herpes simplex virus

KJD:

Korean journal database

MP :

Marginal periodontitis

OR:

Odds ratio

PE:

Porphyromonas endodontalis

PRISMA:

Preferred reporting items for systematic reviews and meta-analyses protocols

PROSPERO:

International prospective register of systematic reviews

RSCI:

Russian science citation index

SCIELO:

SciELO citation index

WoS:

Web of science core collection

ZEBRA:

BamHI fragment Z EB replication activator

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Acknowledgements

This study was not funded. The authors deny any conflict of interest related to this study.

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Authors and Affiliations

  1. Department of Pathophysiology, School of Dental Medicine, University of Belgrade, Belgrade, Serbia

    Aleksandar Jakovljevic

  2. Department of Oral Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia

    Miroslav Andric

  3. Central Library, School of Dental Medicine, University of Belgrade, Belgrade, Serbia

    Jelena Jacimovic

  4. Department of Human Genetics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia

    Jelena Milasin

  5. Facultad de Odontología, Universidad de Antioquia, Medellín, Colombia

    Javier Enrique Botero

Authors
  1. Aleksandar Jakovljevic
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  2. Miroslav Andric
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  3. Jelena Jacimovic
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  4. Jelena Milasin
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  5. Javier Enrique Botero
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Correspondence to Aleksandar Jakovljevic .

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Editors and Affiliations

  1. Science and Healthcare for Oral Welfare, Toulouse, France

    Julien Santi-Rocca

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Jakovljevic, A., Andric, M., Jacimovic, J., Milasin, J., Botero, J.E. (2022). Herpesviruses in Periodontitis: An Umbrella Review. In: Santi-Rocca, J. (eds) Periodontitis. Advances in Experimental Medicine and Biology, vol 1373. Springer, Cham. https://doi.org/10.1007/978-3-030-96881-6_7

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