Skip to main content
SpringerLink
Log in

Arboviruses and Pregnancy (Zika, Dengue, Chikungunya, and Yellow Fever)

  • Chapter
  • First Online:
Perinatology

  • 1451 Accesses

Abstract

Arboviruses are emerging infectious diseases with the ability to expand geographically and rapidly affect large populations. Arbovirus infections can be more severe in pregnant women than in the general population, facing vertical transmission reported for many arboviruses that severely affect pregnancy outcome. The recent epidemic caused by the Zika virus in the Americas and congenital Zika syndrome associated with maternal infection has called out attention to the importance of studying arboviruses during pregnancy. Some issues that should be focused on are the improvement of diagnostic tests, including specific and sensitive molecular tests, associated with ultrasound screening; more accurate estimates of maternal, fetal, and neonatal risks; and the development of preventive vaccines, among other therapeutic options.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Morse SS. Factors in the emergence of infectious diseases. Emerg Infect Dis. 1999;1(1):7–15.

    Google Scholar 

  2. Scrag SJ, Wiener P. Emerging infectious disease: what are the relative roles of ecology and evolution? Trends Ecol Evol. 1995;10(8):319–24.

    Google Scholar 

  3. Abushouk AI, Negida A, Ahmed H. An updated review of zika vírus. J Clin Virol. 2016;84:53–8.

    Google Scholar 

  4. Dick GW, Cozinha SF, Haddow AJ. Zika virus. I: isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952;46(5):509–20.

    CAS  Google Scholar 

  5. Macnamara FN. Zika virus: a report on three cases of human infection during an epidemic of jaundice in Nigeria. Trans R Soc Trop Med Hyg. 1954;48(2):139–45.

    CAS  Google Scholar 

  6. Marchette NJ, Garcia R, Rudnick A. Isolation of zika virus from aedes aegypti mosquitoes in Malaysia. Am J Trop Med Hyg. 1969;18(3):411–5.

    CAS  Google Scholar 

  7. Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009;360:2536–43.

    CAS  Google Scholar 

  8. Cao-Lormeau VM, Roche C, Teissier A, Robin E, Anne-Laure B, Henri-Pierre M, et al. Zika virus, French Polynesia, South Pacific 2013. Emerg Infect Dis. 2014;20(6):1085–6.

    Google Scholar 

  9. Musso D, Nilles EJ, Cao-Lormeau VM. Rapid spread of emerging zika virus in the Pacific area. Clin Microbiol Infect. 2014;20:595–6.

    Google Scholar 

  10. Zanluca C, Melo VCA, Mosimann ALP, Santos GIV, Santos CND. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz. 2015;110(4):569–72.

    CAS  Google Scholar 

  11. PAHO/WHO. Regional Zika epidemiological. http://www.paho.org/hq/index.php?option=com_content&view=article&id=12390&Itemid=42090&lang=en. 2017. Accessed 16 July 2017.

  12. Sudeep AB, Parashar D. Chikungunya: an overview. J Biosci. 2008;33:443–9.

    CAS  Google Scholar 

  13. Leparc-Goffart I, Nougairede A, Cassadou S, Prat C, Lamballerie X. Chikungunya in the Americas. Lancet. 2014;383(9916):514.

    Google Scholar 

  14. Weaver SC, Forrester NL. Chikungunya: evolutionary history and recent epidemic spread. Antivir Res. 2015;120:32–9.

    CAS  Google Scholar 

  15. Nunes MRT, Faria NR, Vasconcelos JM, Golding N, Kraemer MUG, Oliveira LF, et al. Emergence and potential for spread of Chikungunya virus in Brazil. BMC Med. 2015;13:102.

    Google Scholar 

  16. Messina JP, Brady OJ, Scott TW, Zou C, Pigott DM, Duda KA, et al. Global spread of dengue virus types: mapping the 70 year history. Trends Microbiol. 2014;22:138–46.

    CAS  Google Scholar 

  17. Gubler DJ. Human behaviour and cultural context in disease control. Tropical Med Int Health. 1997;2(11):A1–2.

    CAS  Google Scholar 

  18. Gubler DJ. The global emergence/resurgence of arboviral diseases as public health problems. Arch Med Res. 2002;33(4):330–42.

    Google Scholar 

  19. Gardner CL, Ryman KD. Yellow fever: a reemerging threat. Clin Lab Med. 2010;30:237–60.

    Google Scholar 

  20. Monath TP, Vasconcelos PF. Yellow fever. J Clin Virol. 2015;64:160–73.

    Google Scholar 

  21. Paules CI, Fauci AS. Yellow fever – once again on the radar screen in the Americas. N Engl J Med. 2017;376(15):1397–9.

    Google Scholar 

  22. Dick GW, Kitchen SF, et al. Zika virus. I: isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952;46(5):509–20.

    CAS  Google Scholar 

  23. Charlier C, Beaudoin MC, Couderc T, Lortholary O, Lecuit M. Arboviruses and pregnancy: maternal, fetal, and neonatal effects. Lancet Child Adolesc Health. 2017;1(2):134–46. https://doi.org/10.1016/S2352-4642(17)30021-4.

    Article  Google Scholar 

  24. Kim CR, Counotte M, Bernstein K, Deal C, Mayaud P, Low N, et al. Investigating the sexual transmission of Zika virus. Lancet Glob Health. 2018;6:e24–5.

    Google Scholar 

  25. Kumar S. Sexual transmission of Zika virus: more to explore. Lancet Glob Health. 2018;6:e618.

    Google Scholar 

  26. Cardona-Ospina JA, Alvarado-Arnez LE, Escalera-Antezana JP, Bandeira AC, Musso D, Rodríguez-Morales AJ. Sexual transmission of arboviruses: more to explore? Int J Infect Dis. 2018;76:126–7.

    Google Scholar 

  27. Busch MP, Sabino EC, Brambilla D, Lopes ME, Capuani L, Chowdhury D, et al. Duration of dengue viremia in blood donos and relationships between donor viremia, infection incidence and clinical case reports during a large epidemic. J Infect Dis. 2016;214:49–54.

    Google Scholar 

  28. Sabino EC, Loureiro P, Lopes ME, Capuani L, McClure C, Chowdhury D, et al. Transfusion-transmitted dengue and associated clinical symptoms during. The 2012 epidemic in Brazil. J Infect Dis. 2016;231:694–702.

    Google Scholar 

  29. Motta IJ, Spencer BR, Silva CSG, Arruda MB, Dobbin JA, Gonzaga YB, et al. Evidence for transmission of Zika virus by platelet transfusion. N Engl J Med. 2016;375(11):1101–3.

    Google Scholar 

  30. Lanteri MC, Kleinman SH, Glynn SA, Musso D, Keith HW, Custer BS, et al. Zika virus: a new threat to the safety of the blood supply with worldwide impact and implications. Transfusion. 2016;56:1907–14.

    Google Scholar 

  31. Centers for Disease Control and Prevention (CDC). Transfusion-related transmission of yellow fever vaccine vírus – California, 2009. MMWR. 2010;59(2):34–7.

    Google Scholar 

  32. Carvalho FR, Medeiros T, Vianna RAO, et al. Simultaneous circulation of arboviruses and other congenital infections in pregnant women in Rio de Janeiro, Brazil. Acta Trop. 2019;192:49–54.

    Google Scholar 

  33. Mlakar J, Korva M, Tul N, Popović M, Poljšak-Prijatelj M, Mraz J, et al. Zika virus associated with microcephaly. N Engl J Med. 2016;374(10):951–8.

    CAS  Google Scholar 

  34. Araújo TVB, Rodrigues LC, Ximenes RAA, Miranda-Filho DB, Souza WV, Montarroyos UR, et al. Association between microcephaly, Zika virus in- fection, and other risk factors in Brazil: nal report of a case-control study. Lancet Infect Dis. 2018;18:328–36.

    Google Scholar 

  35. Contopoulos-Ioannidis D, Newman-Lindsay S, Chow C, LaBeaud AD. Mother- to-child transmission of Chikungunya virus: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2018;12(6):e0006510.

    Google Scholar 

  36. Gérardin P, Sampériz S, Ramful D, Boumahni B, Bintner M, Alessandri JL, Carbonnier M, Tiran-Rajaoefera I, Beullier G, Boya I, Noormahomed T, Okoï J, Rollot O, Cotte L, Ja ar-Bandjee MC, Michault A, Favier F, Kaminski M, Fourmaintraux A, Fritel X. Neurocognitive outcome of children exposed to perinatal mother-to-child Chikungunya virus infection: the CHIMERE cohort study on Reunion Island. PLoS Negl Trop Dis. 2014;8(7):e2996.

    Google Scholar 

  37. Paixão ES, Teixeira MG, Costa MDCN, Barreto ML, Rodrigues LC. Symptomatic dengue during pregnancy and congenital neurologic malformations. Emerg Infect Dis. 2018;24(9):1748–50.

    Google Scholar 

  38. Bentlin MR, Almeida RA, Coelho KI, Ribeiro AF, Siciliano MM, Suzuki A, et al. Transmissão perinatal de febre amarela, Brasil, 2009. Infect Emerg Dis. 2011;17(9):1779–80. https://doi.org/10.3201/eid1709.110242.

    Article  Google Scholar 

  39. Duffy MR, Chen TH, Hancokc WT, Powers AM, Kool JL, Lanciotti RS, et al. 60. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009;360:2536–43.

    CAS  Google Scholar 

  40. Brasil P, Pereira JP Jr, Moreira ME, Nogueira RMR, Damaceno L, Pharm LD, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 2016;375(24):2321–34. https://doi.org/10.1056/NEJMoa1602412.

    Article  Google Scholar 

  41. Moro ML, Gagliotti C, Silvi G, Angelini R, Sambri V, Rezza G, et al. Chikungunya virus in north-eastern Italy: a seroprevalence survey. Am J Trop Med Hyg. 2010;82(3):508–11.

    Google Scholar 

  42. Adam I, Jumaa AM, Elbashir HM, Karsany MS. Maternal and perinatal outcomes of dengue in PortSudan, Eastern Sudan. Virol J. 2010;7:153.

    Google Scholar 

  43. Machado CR, Machado ES, Rohloff RD, Azevedo M, Campos DP, Oliveira RB, Brasil P. Is pregnancy associated with severe dengue? A review of data from. The Rio de Janeiro surveillance information system. PLoS Negl Trop Dis. 2013;7(5):e2217. https://doi.org/10.1371/journal.pntd.0002217.

    Article  CAS  Google Scholar 

  44. Guzman MG, Alvarez M, Halstead SB. Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. 67. Arch Virol. 2013;158(7):1445–59.

    CAS  Google Scholar 

  45. Wilder-Smith A, Gubler DJ, Weaver SC, Monath TP, Heymann DL, Scott TW. Epidemic arboviral disease: priorities for research and public health. Lancet Infect Dis. 2017;17:e101–6.

    Google Scholar 

  46. Marinho PS, Cunha AJ, Amim Junior J, Prata-Barbosa A. A review of selected Arboviruses during pregnancy. Matern Health Neonatol Perinatol. 2017;3:17. Published 2017 Oct 3. https://doi.org/10.1186/s40748-017-0054-0.

    Article  Google Scholar 

  47. World Health Organization (WHO) and the Special Programme for Research and Training in Tropical Diseases (TDR). Dengue: guidelines for diagnosis, treatment, prevention and control. 9a ed. Genebra: WHO; 2009. http://apps.who.int/iris/bitstream/10665/44188/1/9789241547871_eng.pdf.

    Google Scholar 

  48. Centers for Disease Control and Prevention (CDC). Guidance for U.S. laboratories testing for zika virus infection. https://www.cdc.gov/zika/laboratories/lab-guidance.html.

  49. Centers for Disease Control and Prevention (CDC). Dengue laboratory guidance and diagnostic testing. https://www.cdc.gov/dengue/clinicallab/laboratory.html.

  50. Mussoa D, Rocheb C, Tu-Xuan N, Robina E, Teissierb A, Van-Mai CL. Detection of zika virus in saliva. J Clin Virol. 2015;68:53–5.

    Google Scholar 

  51. Scott LJ. Drugs. 2016;76:1301. https://doi.org/10.1007/s40265-016-0626-8.

    Article  CAS  Google Scholar 

  52. Cavalcanti DP, Salomão MA, Lopez-Camelo J, Pessoto MA. Early exposure to yellow fever vaccine during pregnancy. Tropical Med Int Health. 2007;12(7):833–7.

    Google Scholar 

  53. D’Acremont V, Tremblay S, Genton B. Impact of vacines given during pregnancy on the offspring of women consulting a travel clinic: a longitudinal study. J Travel Med. 2008;15:77–81.

    Google Scholar 

  54. Suzano CE, Amaral E, Sato HK, Papaiordanou PM. The effects of yellow fever immunization (17DD) inadvertently used in early pregnancy during a mass campaign in Brazil. Vaccine. 2006;24:1421–6.

    CAS  Google Scholar 

  55. Imbert P, Moulin F, Mornand P, Mechai F, Rapp C. Should yellow fever vaccination be recommended during pregnancy or breastfeeding? Med Trop. 2010;70(4):321–4.

    CAS  Google Scholar 

  56. Dejnirattisai W, Supasa P, Wongwiwat W, Rouvinski A, Barba-Spaeth G, Duangchinda T. Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. Nat Immunol. 2016;17:1102–8. https://doi.org/10.1038/ni.3515.

    Article  CAS  Google Scholar 

  57. WHO. Zika virus fact sheet: World Health Organization; 2016. http://www.who.int/mediacentre/factsheets/zika/en/. Acessado em 08 de abril de 2017.

  58. Oster AM, Brooks JT, Stryker JE, Kachur RE, Mead P, Pesik NT, Peterse LR. Interim guidelines for prevention of sexual transmission of Zikavirus_United States. MMWR Morb Mortal Wkly Rep. 2016;5(5):120–1.

    Google Scholar 

  59. World Health Organization. Dengue: guidelines for diagnosis, treatment, prevention and control. New ed. Geneva: WHO; 2009. http://www.who.int/tdr/publications/documents/dengue-diagnosis.pdf?ua=1. Accessed on July 2020.

    Google Scholar 

  60. Centers for Disease Control and Prevention. Symptoms and what to do if you think you have dengue. https://www.cdc.gov/dengue/symptoms/.

  61. Oliveira-Szejnfeld PS, Levine D, Melo ASO, Amorim MMR, Batista AGM, Chimelli L, et al. Congenital brain abnormalities and Zika vírus: what the radiologista can expect to see prenatally and postnatally. Radiology. 2016;281(1):203–18.

    Google Scholar 

  62. Honein MA, Dawson AL, Petersen EE, Jones AM, Lee EH, Yazdy MM. Birth defects among fetuses and infants of US women with evidence of possible Zika virus infection during pregnancy. JAMA. 2017;317(1):59–68. https://doi.org/10.1001/jama.2016.19006.

    Article  Google Scholar 

  63. Suwanmanee S, Luplertlop N. Dengue and Zika viruses: lessons learned from the similarities between these Aedes Mosquito-vectored arboviruses. J Microbiol. 2017;55(2):81–9. https://doi.org/10.1007/s12275-017-6494-4.

    Article  Google Scholar 

  64. França GV, Schuler-Faccini L, Oliveira WK, Henriques CM, Carmo EH, Pedi VD, et al. Congenital zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation. Lancet. 2016;388:891–7.

    Google Scholar 

  65. Araújo TVB, Rodrigues LC, Ximenes RAA, Miranda-Filho DB, Montarroyos UR, Melo APL, et al. Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case–control study. Lancet Infect Dis. 2016;16:1356–63.

    Google Scholar 

  66. Cunha AJ, de Magalhães-Barbosa MC, Lima-Setta F, Medronho RA, Prata-Barbosa A. Microcephaly case fatality rate associated with Zika virus infection in Brazil: current estimates. Pediatr Infect Dis J. 2017;36(5):528–30.

    Google Scholar 

  67. Torres JR, Falleiros-Arlant LH, Dueñas L, Pleitez-Navarrete J, Salgado DM, Castillo JB. Congenital and perinatal complications of chikungunya fever: a Latin American experience. Int J Infect Dis. 2016;51:85–8. https://doi.org/10.1016/j.ijid.57.2016.09.009.

    Article  Google Scholar 

  68. Paixão ES, Teixeira MG, Costa MC, Rodrigues LC. Dengue during pregnancy and adverse fetal outcomes: a systematic review and meta-analysis. Lancet Infect Dis. 2016;16:857–65.

    Google Scholar 

  69. Friedman EE, Dallah F, Harville EW, Myers L, Buekens P, Breart G, Carles G. Symptomatic dengue infection during pregnancy and infant outcomes: a retrospective cohort study. PLoS Negl Trop Dis. 2014;8(10):e3226.

    Google Scholar 

  70. Christiane FR, Lopes VGS, Brasil P, Pires ARC, Rohloffe R, Nogueira RMR. Dengue infection in pregnancy and its impact on the placenta. Int J Infect Dis. 2017;55:109–12.

    Google Scholar 

  71. Xiong X, Harville E, Paz-Soldão V, Tomashek KM, Breart L, Buekens P. Maternal dengue and pregnancy outcomes: a systematic review. Obstet Gynecol Surv. 2010;65(2):107–18.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Maternidade Escola da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Penélope Saldanha Marinho & Joffre Amim Junior

  2. Faculdade de Medicina da Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Antonio José Cunha

  3. Instituto D’Or de Pesquisa e Ensino - IDOR, Rio de Janeiro, Brazil

    Arnaldo Prata Barbosa

Authors
  1. Penélope Saldanha Marinho
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Antonio José Cunha
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joffre Amim Junior
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Arnaldo Prata Barbosa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Penélope Saldanha Marinho .

Editor information

Editors and Affiliations

  1. Maternal and Child Department, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

    Renato Augusto Moreira de Sá

  2. Federal University of Paraíba, João Pessoa, Paraíba, Brazil

    Eduardo Borges da Fonseca

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Marinho, P.S., Cunha, A.J., Junior, J.A., Barbosa, A.P. (2022). Arboviruses and Pregnancy (Zika, Dengue, Chikungunya, and Yellow Fever). In: Moreira de Sá, R.A., Fonseca, E.B.d. (eds) Perinatology. Springer, Cham. https://doi.org/10.1007/978-3-030-83434-0_47

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-83434-0_47

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-83433-3

  • Online ISBN: 978-3-030-83434-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation