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A Timeline of Perezone, the First Isolated Secondary Metabolite in the New World, Covering the Period from 1852 to 2020

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Progress in the Chemistry of Organic Natural Products 116

Part of the book series: Progress in the Chemistry of Organic Natural Products ((POGRCHEM,volume 116))

Abstract

This chapter covers a sesquiterpene quinone, commonly named perezone. This molecule is documented as the first secondary metabolite isolated in crystalline form in the New World in 1852. An introduction, with its structure, the IUPAC nomenclature, and the most recent physical and spectroscopic characterizations are firstly described initially. Alongside this, a timeline and scheme with summarized information of the history of this molecule is given including the “Códice Badiano de la Cruz, 1552, highlighting the year of its isolation culminating with information up to 2005. Subsequently, in a chronological order the most recent advances of the target molecule are included and organized in subsections covering the last 15-year period 2006–2020. Finally, recently submitted contributions from the laboratory of the authors are described. It is important to note that the details provided highlight the importance and relevance of perezone.

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Acknowledgments

The authors are grateful to PAPIIT-UNAM IN212421, in addition to the Dirección General de Cómputo y de Tecnologías de Información y Comunicación (DGTIC-UNAM) for the use of the supercomputer MIZTLI-LANCAD-UNAM-DGTIC-400. Thanks are due to Moisés Hernández Duarte for technical assistance. Pablo Mendoza acknowledges CONACyT for a Ph.D. scholarship (CVU 685907/628682).

Author information

Authors and Affiliations

  1. Department of Industrial Maintenance and Nanotechnology, Technological University of Juarez City, 32695, Ciudad Juarez, Chihuahua, Mexico

    René Escobedo-González

  2. Department of Chemistry, Faculty of Superior Studies Cuautitlan, National Autonomous University of Mexico, Mexico State, Campus 1, 54740, Cuautitlan Izcalli, Mexico

    Pablo Mendoza, María Inés Nicolás-Vázquez & René Miranda Ruvalcaba

  3. Cell Culture Laboratory, Medicine Higher School, National Polytechnic Institute, 11340, Mexico City, Mexico

    Maricarmen Hernández-Rodríguez

  4. Chemistry Science Faculty, Autonomous University of San Luis Potosi, San Luis Potosi, 78210, Mexico

    Joel Martínez

Authors
  1. René Escobedo-González
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  2. Pablo Mendoza
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  3. María Inés Nicolás-Vázquez
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  4. Maricarmen Hernández-Rodríguez
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  5. Joel Martínez
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  6. René Miranda Ruvalcaba
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Corresponding authors

Correspondence to Joel Martínez or René Miranda Ruvalcaba .

Editor information

Editors and Affiliations

  1. College of Pharmacy, Ohio State University, Columbus, OH, USA

    A. Douglas Kinghorn

  2. Institute of Organic Chemistry, Johannes Kepler University, Linz, Austria

    Heinz Falk

  3. School of Pharmacy, University of East Anglia, Norwich, UK

    Simon Gibbons

  4. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Yoshinori Asakawa

  5. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China

    Ji-Kai Liu

  6. Department of Pharmacognosy, University of Vienna, Vienna, Wien, Austria

    Verena M. Dirsch

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Escobedo-González, R., Mendoza, P., Nicolás-Vázquez, M.I., Hernández-Rodríguez, M., Martínez, J., Miranda Ruvalcaba, R. (2021). A Timeline of Perezone, the First Isolated Secondary Metabolite in the New World, Covering the Period from 1852 to 2020. In: Kinghorn, A.D., Falk, H., Gibbons, S., Asakawa, Y., Liu, JK., Dirsch, V.M. (eds) Progress in the Chemistry of Organic Natural Products 116. Progress in the Chemistry of Organic Natural Products, vol 116. Springer, Cham. https://doi.org/10.1007/978-3-030-80560-9_3

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