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An Unusual Evolutionary Strategy: The Origins, Genetic Repertoire, and Implications of Doubly Uniparental Inheritance of Mitochondrial DNA in Bivalves

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Evolutionary Biology—A Transdisciplinary Approach

Abstract

Mitochondrial DNA (mtDNA) is typically passed on to progeny only by the female parent. The phenomenon of “doubly uniparental inheritance” (DUI) of mtDNA in many bivalve species is a fascinating exception to the paradigm of strict maternal inheritance of mtDNA. In this review, we survey the current state of knowledge of DUI and discuss several active areas of research in this field. Topics/questions covered include: the number of times DUI evolved (once or multiple origins), the link between DUI and sex determination, the role(s) of mtDNA-encoded non-oxidative phosphorylation genes (i.e. ORFan/orf genes) in freshwater mussels, the function of conserved sequence motifs and sperm transmission elements in mtDNA of marine mussels, the challenges of annotating mtDNA genomes of DUI species, the presence of unorthodox features in venerid mtDNA, whether or not orf DNA sequences are useful in species-level identification of freshwater mussel, and finally, whether or not there are obvious benefits of DUI. For each topic, we also highlight important avenues for future research within this fascinating field of mitochondrial evolutionary biology.

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Acknowledgements

DTS and SB were funded by NSERC Discovery grants. EEC was funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No713750, carried out with the financial support of the Regional Council of Provence- Alpes-Côte d’Azur and with the financial support of the A*MIDEX (n° ANR- 11-IDEX-0001-02), funded by the Investissements d’Avenir project funded by the French Government, managed by the French National Research Agency [ANR]). At time of submission, an NSERC CGS-D supported BMR. MAGR was supported by a Harrison McCain Visiting Professorship Award from the Harrison McCain Foundation.

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Authors and Affiliations

  1. Department of Biology, Acadia University, Wolfville, NS, B4P 2R6, Canada

    Donald T. Stewart

  2. Département de Sciences Biologiques, Université de Montréal, Montréal, QC, H3C 3J7, Canada

    Sophie Breton & Stefano Bettinazzi

  3. Institut Méditerranéen d’Océanologie, Aix-Marseille University, 13288, Marseille, France

    Emily E. Chase

  4. Department of Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada

    Brent M. Robicheau & Noor Youssef

  5. Littoral, Environnement et Sociétés Joint Research Unit, 7266 Centre National de la recherche Scientifique, Université de La Rochelle, La Rochelle, France

    Eric Pante

  6. Departamento de Genética, Facultad de Ciencias, Universidad de Granada, 18071, Granada, Spain

    Manuel A. Garrido-Ramos

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  1. Donald T. Stewart
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  8. Manuel A. Garrido-Ramos
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Correspondence to Donald T. Stewart .

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  1. IHU Marseille MEPHI, Aix Marseille Univ IRD, APHM, Marseille, France

    Pierre Pontarotti

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Stewart, D.T. et al. (2020). An Unusual Evolutionary Strategy: The Origins, Genetic Repertoire, and Implications of Doubly Uniparental Inheritance of Mitochondrial DNA in Bivalves. In: Pontarotti, P. (eds) Evolutionary Biology—A Transdisciplinary Approach. Springer, Cham. https://doi.org/10.1007/978-3-030-57246-4_12

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