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Pediatric Acute Ischemic Stroke: Nuances for the Neurointerventionalist

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12 Strokes

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Abstract

Acute ischemic stroke (AIS) is unusual in childhood. Nevertheless, childhood AIS accounts for substantial mortality in the first two decades of life, and most survivors have long-term neurological impairment resulting in negative impact on quality of life for affected patients and their families. The relative rarity, age-related peculiarities, and the variety of manifested symptoms make the clinical diagnosis of pediatric AIS extremely difficult [1]. In particular, the disproportionately greater frequency of clinical stroke mimics presenting in children demands advanced neuroimaging studies for diagnostic confirmation and confounds the goal of rapid diagnosis of AIS. Most pediatric AIS patients are therefore ineligible for reperfusion with intravenous thrombolytic therapy by the time they come to diagnosis. Furthermore, pediatric protocols for intravenous thrombolytic therapy are not supported by clinical trial data and are lacking at most centers. The clinical outcomes of pediatric AIS are thus worsened by delayed diagnosis and lack of well-established, readily available treatment protocols.

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Author information

Authors and Affiliations

  1. Hospital Maciel, Montevideo, Uruguay

    Matias Negrotto

  2. Monash Health and Monash University, NeuroInterventional Radiology, Melbourne, VIC, Australia

    Ronil V. Chandra

  3. Barrow Neurological Institute at Phoenix Children’s Hospital, Phoenix, AZ, USA

    Todd A. Abruzzo

  4. University of Arizona College of Medicine, Phoenix, AZ, USA

    Todd A. Abruzzo

  5. Phoenix Children’s Hospital, Phoenix, AZ, USA

    Todd A. Abruzzo

Authors
  1. Matias Negrotto
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  2. Ronil V. Chandra
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  3. Todd A. Abruzzo
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Editor information

Editors and Affiliations

  1. Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, USA

    Ferdinand K. Hui

  2. Department of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA

    Alejandro M. Spiotta

  3. Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Michael J. Alexander

  4. Baptist Neurological Institute, Jacksonville, FL, USA

    Ricardo A. Hanel

  5. Department of Radiology, Lehigh Valley Health Network, Allentown, PA, USA

    Blaise William Baxter

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Negrotto, M., Chandra, R.V., Abruzzo, T.A. (2021). Pediatric Acute Ischemic Stroke: Nuances for the Neurointerventionalist. In: Hui, F.K., Spiotta, A.M., Alexander, M.J., Hanel, R.A., Baxter, B.W. (eds) 12 Strokes. Springer, Cham. https://doi.org/10.1007/978-3-030-56857-3_3

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