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A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis

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Studies on Biomarkers and New Targets in Aging Research in Iran

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1291))

Abstract

Osteoarthritis is characterized by degeneration of joint structure over time, resulting in limitation of joint mobility. There is growing evidence that curcumin has anti-inflammatory properties and could be a potential therapeutic option for chronic inflammatory diseases. Hence, curcumin could potentially have a positive impact on osteoarthritis symptoms. This systematic review aimed to estimate the effects of curcumin on osteoarthritis. We systematically searched PubMed, ISI, Scopus, and Google Scholar up to March 4, 2020 to identify randomized controlled trials that evaluated the effects of consumption of all types of curcumin compounds in the treatment of osteoarthritis, especially in patients with knee osteoarthritis. Seventeen trials were identified. The duration of the included studies varied from 4 weeks to 8 months. Across all trials, 13 studies involved screening using Western Ontario and McMaster Universities (WOMAC) scores and 11 studies used visual analog scales (VAS) for recording pain from baseline to post-intervention. There was a significant improvement in VAS and overall WOMAC scores with oral administration of various types of curcumin formulations with no severe adverse effects. In conclusion, different types of curcumin compounds may be beneficial as an alternative or complementary agent for the management of osteoarthritis. Moreover, certain curcumin compounds with higher bioavailability tended to show more positive effects.

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References

  1. Poole AR (2012) Osteoarthritis as a whole joint disease. HSS J 8(1):4–6

    Article  PubMed  PubMed Central  Google Scholar 

  2. Loeser RF (2011) Aging and osteoarthritis. Curr Opin Rheumatol 23(5):492–496

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ma VY, Chan L, Carruthers KJ (2014) Incidence, prevalence, costs, and impact on disability of common conditions requiring rehabilitation in the United States: stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, osteoarthritis, rheumatoid arthritis, limb loss, and back pain. Arch Phys Med Rehab 95(5):986–995.e981

    Article  Google Scholar 

  4. Fransen M, Bridgett L, March L, Hoy D, Penserga E, Brooks P (2011) The epidemiology of osteoarthritis in Asia. Int J Rheum Dis 14(2):113–121

    Article  PubMed  Google Scholar 

  5. Loeser RF, Collins JA, Diekman BO (2016) Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol 12(7):412–420

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Zhang R, Ma J, Yao J (2013) Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis. Inflamm Res 62(10):871–877

    Article  CAS  PubMed  Google Scholar 

  7. Lee AS, Ellman MB, Yan D, Kroin JS, Cole BJ, van Wijnen AJ et al (2013) A current review of molecular mechanisms regarding osteoarthritis and pain. Gene 527(2):440–447

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Crawford DC, Miller LE, Block JE (2013) Conservative management of symptomatic knee osteoarthritis: a flawed strategy? Orthop Rev (Pavia) 5(1):e2. https://doi.org/10.4081/or.2013.e2

    Article  Google Scholar 

  9. Liu X, McLachlan A, Hunter D (2019) Vitamin and mineral supplements: the role of supplements and complementary medicines in osteoarthritis: an evidence-based guide to practice. Aust J Pharm 100(1180):62–68

    Google Scholar 

  10. Shirali S, Mashhadi NS, Ashtary-Larky D, Safania T, Barari A (2016) Effects of silymarin supplementation on leptin, adiponectin and paraoxanase levels and body composition during exercise: a randomized double-blind placebo controlled clinical trial. Jundishapur J Nat Pharm Prod 11(4):e30044. https://doi.org/10.17795/jjnpp-30044

    Article  CAS  Google Scholar 

  11. Mashhadi NS, Ghiasvand R (2019) The role of nutraceuticals in preeclampsia and eclampsia. In: Bhatt P, Miraghajani MS, Pathak S, Pathak Y (eds) Nutraceuticals for prenatal, maternal, and offspring’s nutritional health. CRC Press, Cleveland, OH. 1138345822

    Google Scholar 

  12. Abdollahi E, Momtazi AA, Johnston TP, Sahebkar A (2018) Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: a nature-made jack-of-all-trades? J Cell Physiol 233(2):830–848

    Article  CAS  PubMed  Google Scholar 

  13. Sahebkar A, Saboni N, Pirro M, Banach M (2017) Curcumin: An effective adjunct in patients with statin-associated muscle symptoms? J Cachexia Sarcopenia Muscle 8(1):19–24. https://doi.org/10.1002/jcsm.12140. Epub 2016 Sep 22. PMID: 27897416; PMCID: PMC5326825

  14. Soleimani V, Sahebkar A, Hosseinzadeh H (2018) Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res 32(6):985–995. https://doi.org/10.1002/ptr.6054. Epub 2018 Feb 26. PMID: 29480523

  15. Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B et al (2008) Biological activities of curcumin and its analogues (Congeners) made by man and mother nature. Biochem Pharmacol 76(11):1590–1611

    Article  CAS  PubMed  Google Scholar 

  16. Bagherniya M, Nobili V, Blesso CN, Sahebkar A (2018) Medicinal plants and bioactive natural compounds in the treatment of non-alcoholic fatty liver disease: a clinical review. Pharmacol Res 130:213–240

    Article  CAS  PubMed  Google Scholar 

  17. Iranshahi M, Sahebkar A, Hosseini ST, Takasaki M, Konoshima T, Tokuda H (2020) Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. Phytomedicine 17(3–4):269-–73. https://doi.org/10.1016/j.phymed.2009.05.020. Epub 2009 Jul 3. PMID: 19577457. 

  18. Momtazi AA, Sahebkar A (2016) Difluorinated curcumin: a promising curcumin analogue with improved anti-tumour activity and pharmacokinetic profile. Curr Pharm Des 22(28):4386–4397

    Article  CAS  PubMed  Google Scholar 

  19. Teymouri M, Pirro M, Johnston TP, Sahebkar A (2017) Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: A review of chemistry, cellular, molecular, and preclinical features. BioFactors 43(3):331–346

    Google Scholar 

  20. Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M, Sahebkar A (2019) Immune modulation by curcumin: the role of interleukin-10. Crit Rev Food Sci Nutr 59(1):89–101

    Google Scholar 

  21. Shishodia S, Sethi G, Aggarwal BB (2005) Curcumin: getting back to the roots. Ann N Y Acad Sci 1056(1):206–217

    Article  CAS  PubMed  Google Scholar 

  22. Momtazi AA, Derosa G, Maffioli P, Banach M, Sahebkar A (2016) Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases. Mol Diag Ther 20(4):335–345

    Article  CAS  Google Scholar 

  23. Bagheri H, Ghasemi F, Barreto GE, Rafiee R, Sathyapalan T, Sahebkar A (2020) Effects of curcumin on mitochondria in neurodegenerative diseases. Biofactors 46(1):5–20. https://doi.org/10.1002/biof.1566. Epub 2019 Oct 3. PMID: 31580521

  24. Sadeghian M, Rahmani S, Jamialahmadi T, Johnston TP, Sahebkar A (2020) The effect of oral curcumin supplementation on healthrelated quality of life: A systematic review and meta-analysis of randomized controlled trials. J Affect Disord 29;278:627–636. https://doi.org/10.1016/j.jad.2020.09.091. Epub ahead of print. PMID: 33038707

  25. Mohajeri M, Bianconi V, Ávila-Rodriguez MF, Barreto GE, Jamialahmadi T, Pirro M, Sahebkar A (2020) Curcumin: a phytochemical modulator of estrogens and androgens in tumors of the reproductive system. Pharmacol Res 156:104765. https://doi.org/10.1016/j.phrs.2020.104765. Epub 2020 Mar 23. PMID: 32217147

  26. Onakpoya IJ, Spencer EA, Perera R, Heneghan CJ (2017) Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials. Int J Rheum Dis 20(4):420–433

    Article  CAS  PubMed  Google Scholar 

  27. Mathy-Hartert M, Jacquemond-Collet I, Priem F, Sanchez C, Lambert C, Henrotin Y (2009) Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm Res 58(12):899. https://doi.org/10.1007/s00011-009-0063-1

    Article  CAS  PubMed  Google Scholar 

  28. Yeh CC, Su YH, Lin YJ, Chen PJ, Shi CS, Chen CN et al (2015) Evaluation of the protective effects of curcuminoid (curcumin and bisdemethoxycurcumin)-loaded liposomes against bone turnover in a cell-based model of osteoarthritis. Drug Des Devel Ther 9:2285–2300

    PubMed  PubMed Central  Google Scholar 

  29. Zhang Z, Leong DJ, Xu L, He Z, Wang A, Navati M et al (2016) Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther 18(1):128. https://doi.org/10.1186/s13075-016-1025-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Chin KY (2016) The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis. Drug Des Devel Ther 10:3029–3042

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Hasanzadeh S, Read MI, Bland AR, Majeed M, Jamialahmadi T, Sahebkar A (2020) Curcumin: an inflammasome silencer. Pharmacol Res 159:104921. https://doi.org/10.1016/j.phrs.2020.104921. Epub 2020 May 25. PMID: 32464325.

  32. Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z, Sahebkar A (2017) Phytosomal curcumin: a review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother 85:102–112

    Article  CAS  PubMed  Google Scholar 

  33. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17(1):1–12

    Article  CAS  PubMed  Google Scholar 

  34. Moher D, Cook D, Jadad A, Tugwell P, Moher M, Jones A et al (1999) Assessing the quality of reports of randomised trials: implications for the conduct of meta-analyses. Health Technol Assess 3(12):i–iv. 1–98

    Article  CAS  PubMed  Google Scholar 

  35. Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A (2014) Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res 28(11):1625–1631

    Article  CAS  PubMed  Google Scholar 

  36. Rahimnia AR, Panahi Y, Alishiri G, Sharafi M, Sahebkar A (2015) Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: findings from a randomized double-blind placebo-controlled trial. Drug Res 65(10):521–525

    CAS  Google Scholar 

  37. Panahi Y, Alishiri GH, Parvin S, Sahebkar A (2016) Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: results of a randomized controlled trial. J Diet Suppl 13(2):209–220

    Article  CAS  PubMed  Google Scholar 

  38. Henrotin Y, Malaise M, Wittoek R, de Vlam K, Brasseur JP, Luyten F et al (2019) Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study. Arthritis Res Ther 21(1):179. https://doi.org/10.1186/s13075-020-2109-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Belcaro G, Cesarone M, Dugall M, Pellegrini L, Ledda A, Grossi M et al (2010) Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med 52(2 Suppl 1):55–62

    CAS  PubMed  Google Scholar 

  40. Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG et al (2010) Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev 15(4):337–344

    PubMed  Google Scholar 

  41. Gupte PA, Giramkar SA, Harke SM, Kulkarni SK, Deshmukh AP, Hingorani LL et al (2019) Evaluation of the efficacy and safety of Capsule Longvida® Optimized Curcumin (solid lipid curcumin particles) in knee osteoarthritis: a pilot clinical study. J Inflamm Res 12:145–152

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Hashemzadeh K, Davoudian N, Jaafari MR, Mirfeizi Z (2019) The effect of nanocurcumin on the improvement symptoms of knee osteoarthritis: a randomized clinical trial. Curr Rheumatol Rev. https://doi.org/10.2174/1874471013666191223152658. [Epub ahead of print]

  43. Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T et al (2014) Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci 19(6):933–939

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C et al (2014) Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging 9:451–458

    Article  PubMed  PubMed Central  Google Scholar 

  45. Madhu K, Chanda K, Saji M (2013) Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology 21(2):129–136

    Article  CAS  PubMed  Google Scholar 

  46. Nirvanashetty S, Parachur VA, Mohanty N, Swain T (2018) A randomized, double blind, placebo controlled, parallel-group study to evaluate the safety and efficacy of Curene® versus placebo in reducing symptoms of knee OA. Biomed Res Int 2018:5291945. https://doi.org/10.1155/2018/5291945

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Srivastava S, Saksena AK, Khattri S, Kumar S, Dagur RS (2016) Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial. Inflammopharmacology 24(6):377–388

    Article  PubMed  Google Scholar 

  48. Pinsornsak P, Niempoog S (2012) The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial. J Med Assoc Thail 95(Suppl 1):S51–S58

    Google Scholar 

  49. Shep D, Khanwelkar C, Gade P, Karad S (2019) Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials. https://doi.org/10.1186/s13063-019-3327-2

  50. Haroyan A, Mukuchyan V, Mkrtchyan N, Minasyan N, Gasparyan S, Sargsyan A et al (2018) Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med 18:7. https://doi.org/10.1186/s12906-017-2062-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Shin YA, Suk MH, Jang HS, Choi HJ (2017) Short-term effects of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis. J Exerc Rehabil 13(6):684–692

    Article  PubMed  PubMed Central  Google Scholar 

  52. McConnell S, Kolopack P, Davis AM (2001) The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC): a review of its utility and measurement properties. Arthritis Care Res 45(5):453–461

    Article  CAS  Google Scholar 

  53. Ebrahimzadeh MH, Makhmalbaf H, Birjandinejad A, Keshtan FG, Hoseini HA, Mazloumi SM (2014) The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in Persian speaking patients with knee osteoarthritis. J Bone Joint Surg 2(1):57–62

    Google Scholar 

  54. Hewlings SJ, Kalman DS (2017) Curcumin: a review of its’ effects on human health. Foods 6(10):92. https://doi.org/10.3390/foods6100092

    Article  CAS  PubMed Central  Google Scholar 

  55. Menon VP, Sudheer AR (2007) Antioxidant and anti-inflammatory properties of curcumin. In: Aggarwal BB, Surh YJ, Shishodia S (eds) The molecular targets and therapeutic uses of curcumin in health and disease. Springer, New York, NY, pp 105–125. ISBN-10: 038746400X

    Chapter  Google Scholar 

  56. Chainani-Wu N (2003) Safety and anti-inflammatory activity of curcumin: a component of turmeric (Curcuma longa). J Altern Complement Med 9(1):161–168

    Article  PubMed  Google Scholar 

  57. Sahebkar A, Serban MC, Ursoniu S, Banach M (2015) Effect of curcuminoids on oxidative stress: a systematic review and meta-analysis of randomized controlled trials. J Funct Foods 18:898–909

    Article  CAS  Google Scholar 

  58. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4(6):807–818

    Article  CAS  PubMed  Google Scholar 

  59. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas P (1998) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64(4):353–356

    Article  CAS  PubMed  Google Scholar 

  60. Zou L, Liu W, Liu C, Xiao H, McClements DJ (2015) Designing excipient emulsions to increase nutraceutical bioavailability: emulsifier type influences curcumin stability and bioaccessibility by altering gastrointestinal fate. Food Funct 6(8):2475–2486

    Article  CAS  PubMed  Google Scholar 

  61. Mondal S, Ghosh S, Moulik SP (2016) Stability of curcumin in different solvent and solution media: UV–visible and steady-state fluorescence spectral study. J Photochem Photobiol B 158:212–218

    Article  CAS  PubMed  Google Scholar 

  62. Zheng B, Zhang Z, Chen F, Luo X, McClements DJ (2017) Impact of delivery system type on curcumin stability: comparison of curcumin degradation in aqueous solutions, emulsions, and hydrogel beads. Food Hydrocoll 71:187–197

    Article  CAS  Google Scholar 

  63. Peng S, Li Z, Zou L, Liu W, Liu C, McClements DJ (2018) Enhancement of curcumin bioavailability by encapsulation in sophorolipid-coated nanoparticles: an in vitro and in vivo study. J Agric Food Chem 66(6):1488–1497

    Article  CAS  PubMed  Google Scholar 

  64. Cheragh-Birjandi S, Moghbeli M, Haghighi F, Safdari MR, Baghernezhad M, Akhavan A et al (2020) Impact of resistance exercises and nano-curcumin on synovial levels of collagenase and nitric oxide in women with knee osteoarthritis. Transl Med Commun 5(1):1–6

    Article  Google Scholar 

  65. Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP, Gescher AJ (2007) Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol 60(2):171–177

    Article  CAS  PubMed  Google Scholar 

  66. Bhadoriya SS, Mangal A, Madoriya N, Dixit P (2011) Bioavailability and bioactivity enhancement of herbal drugs by “Nanotechnology”: a review. J Curr Pharm Res 8:1–7

    Google Scholar 

  67. Gupta NK, Dixit VK (2011) Bioavailability enhancement of curcumin by complexation with phosphatidyl choline. J Pharm Sci 100(5):1987–1995

    Article  CAS  PubMed  Google Scholar 

  68. Klimek L, Bergmann KC, Biedermann T, Bousquet J, Hellings P, Jung K et al (2017) Visual analogue scales (VAS): Measuring instruments for the documentation of symptoms and therapy monitoring in cases of allergic rhinitis in everyday health care. Allergo J Int 26(1):16–24

    Article  PubMed  PubMed Central  Google Scholar 

  69. Hawker GA, Mian S, Kendzerska T, French M (2011) Measures of adult pain: Visual analog scale for pain (vas pain), numeric rating scale for pain (nrs pain), mcgill pain questionnaire (mpq), short-form mcgill pain questionnaire (sf-mpq), chronic pain grade scale (cpgs), short form-36 bodily pain scale (sf-36 bps), and measure of intermittent and constant osteoarthritis pain (icoap). Arthritis Care Res 63(S11):S240–S252

    Article  Google Scholar 

  70. Lepetsos P, Papavassiliou AG (2016) ROS/oxidative stress signaling in osteoarthritis. Biochim Biophys Acta 1862(4):576–591

    Article  CAS  PubMed  Google Scholar 

  71. Ozgocmen S, Ardicoglu O, Erdogan H, Fadillioglu E, Gudul H (2005) In vivo effect of celecoxib and tenoxicam on oxidant/anti-oxidant status of patients with knee osteoarthritis. Ann Clin Lab Sci 35(2):137–143

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Nafiseh Shokri-Mashhadi

  2. Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

    Mohammad Bagherniya & Gholamreza Askari

  3. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

    Thozhukat Sathyapalan

  4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  5. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  6. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

    Amirhossein Sahebkar

  7. Halal Research Center of IRI, FDA, Tehran, Iran

    Amirhossein Sahebkar

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  1. Nafiseh Shokri-Mashhadi
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  2. Mohammad Bagherniya
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  3. Gholamreza Askari
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  4. Thozhukat Sathyapalan
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  5. Amirhossein Sahebkar
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Correspondence to Amirhossein Sahebkar .

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  1. University of Campinas, Sao Paulo, Brazil

    Paul C. Guest

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Shokri-Mashhadi, N., Bagherniya, M., Askari, G., Sathyapalan, T., Sahebkar, A. (2021). A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis. In: Guest, P.C. (eds) Studies on Biomarkers and New Targets in Aging Research in Iran. Advances in Experimental Medicine and Biology(), vol 1291. Springer, Cham. https://doi.org/10.1007/978-3-030-56153-6_16

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