Abstract
Wound healing in diabetes is remarkably delayed due to various underlying pathological processes. Diabetes alters all the stages of wound healing such as remodeling, proliferation, hemostasis, and inflammatory phases. In diabetic patients, minor skin lesions may lead to unhealed chronic ulcers, and ultimately result in infection, gangrene, even amputation. Physiological factors responsible for the delay of wound healing include impaired growth factor and cytokine production, angiogenic response, macrophage and neutrophil function, collagen accumulation, and variation in the ratio of collagen types leading to weakened healing response. Key molecular targets for the local/pharmacologic treatment of wound healing include growth factors and other molecules, absorbable biomaterials, and cell regeneration therapy.
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Acknowledgments
The authors are thankful to the Director, University Institute of Pharmacy, Pt. Ravishankar Shukla, University Raipur, Chhattisgarh, for providing necessary infrastructure facilities and DHR-ICMR project no. V.25011/286-HRD/2016-HR for financial support.
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Patel, S. et al. (2020). Pathogenesis and Molecular Targets in Treatment of Diabetic Wounds. In: Faintuch, J., Faintuch, S. (eds) Obesity and Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-030-53370-0_55
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