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Sterility and Infection

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Biomedical Materials

Abstract

Biomaterials implanted into the body need to be sterile in order to avoid infections which can lead to illness and even mortality. Sterility can be defined as the absence of all living organisms, particularly microorganisms. Indeed, the presence of one bacterium would render a medical device non-sterile. Nearly one-third of implant-related infections can be prevented by strictly following established infection control guidelines, but in a period of healthcare cost reductions, this is increasingly difficult to sustain.

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References

  1. Addy M, Martin MV. Systemic antimicrobials in the treatment of chronic periodontal diseases: a dilemma. Oral Dis. 2003;9:38–44.

    Article  Google Scholar 

  2. An YH, Friedman RJ. Concise review of mechanisms of bacterial adhesion to biomaterial surfaces. J Biomed Mater Res. 1998;43:338–48.

    Article  CAS  Google Scholar 

  3. Andersson-Wenckert IE, van Dijken JW, Kieri C. Durability of extensive class II open-sandwich restorations with a resin-modified glass ionomer cement after 6 years. Am J Dent. 2004;17(1):43–50.

    Google Scholar 

  4. Bayston R. Medical problems due to biofilms: clinical impact, aetiology, molecular pathogenesis, treatment and prevention. In: Newman HN, Wilson M, editors. Dental plaques revisited: oral biofilms in health and disease. Cardiff: Bioline; 1999.

    Google Scholar 

  5. Bayston R. Biofilms in medicine and disease: an overview. In: Wimpenny J, Gilbert P, Walker J, Brading M, Bayston R, editors. Biofilms: the good, the bad and the ugly. Cardiff: Bioline; 1999.

    Google Scholar 

  6. Beikler T, Prior K, Ehmke B, Flemmig TF. Specific antibiotics in the treatment of periodontitis – a proposed strategy. J Periodontol. 2004;75:169–75.

    Article  Google Scholar 

  7. Berbari EF, Hanssen AD, Duffy MC, Steckelberg JM, Ilstrup DM, Harmsen WS, Osmon DR. Risk factors for prosthetic joint infection: case control study. Clin Infect Dis. 1998;27:1247–54.

    Article  CAS  Google Scholar 

  8. Bernard L, Hoffmeyer P, Assal M, Vaudaux P, Schrenzel J, Lew D. Trends in the treatment of orthopaedic prosthetic infections. J Antimicrob Chemother. 2004;53:127–9.

    Article  CAS  Google Scholar 

  9. Boxma H, Broekhuizen T, Patka P, Oosting H. Randomised controlled trial of single dose antibiotic prophylaxis in surgical treatment of closed fractures: the Dutch Trauma Trial. Lancet. 1996;347:1133–7.

    Article  CAS  Google Scholar 

  10. Brisset L, Vernet-Garnier V, Carquin J, Burde A, Flament JB, Choisy C. In vivo and in vitro analysis of the ability of urinary catheters to microbial colonization. Pathol Biol. 1996;44:397–404.

    CAS  Google Scholar 

  11. Buchholz HW, Englebrecht H. Depot effects of various antibiotics mixed with Palacos resins. Chirurg. 1970;41:511–5.

    CAS  Google Scholar 

  12. Burrows LL, Khoury AE. Infection of medical devices. In: Wnek GE, Bowlin GL, editors. Encyclopedia of biomaterials and biomedical engineering. New York: Marcel Dekker Inc; 2004.

    Google Scholar 

  13. Charnley J. Postoperative infection after total hip replacements with special reference to air contamination in the operating room. Clin Orthop. 1972;87:167–87.

    Article  CAS  Google Scholar 

  14. Ching DW, Gould IM, Rennie JA, Gibson PH. Prevention of late haematogenous infection in major prosthetic joints. J Antimicrob Chemother. 1989;23:676–80.

    Article  CAS  Google Scholar 

  15. Combe E. Dental biomaterials. Boston/London: Kluwer Academic Publishers; 1999.

    Google Scholar 

  16. Darouiche RO. Antimicrobial approaches for preventing infections associated with surgical implants. Clin Infect Dis. 2003;36:1284–9.

    Article  Google Scholar 

  17. Donlan RM. Biofilms and device-associated infections. Emerg Infect Dis. 2001;7:277–81.

    Article  CAS  Google Scholar 

  18. Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev. 2002;15:167–93.

    Article  CAS  Google Scholar 

  19. Furno F, Bayston R. Antimicrobial/antibiotic (infective resistance) materials. In: Wnek GE, Bowlin GL, editors. Encyclopedia of biomaterials and biomedical engineering. New York: Marcel Dekker Inc; 2004.

    Google Scholar 

  20. Garvin KL, Fitzgerald RH Jr, Salvati EA, Brause BD, Nercessian OA, Wallrichs SL, Ilstrup DM. Reconstruction of the infected total hip or knee arthroplasty with gentamicin-impregnated Palacos bone cement. Instr Course Lect. 1993;42:293–302.

    CAS  Google Scholar 

  21. Gilbert P, Das J, Foley I. Biofilm susceptibility to antimicrobials. Adv Dent Res. 1997;11:160–7.

    Article  CAS  Google Scholar 

  22. Götz F. Staphylococcus and biofilms. Mol Microbiol. 2002;43:1367–78.

    Article  Google Scholar 

  23. Henderson B, Nair SP. Hard labour: bacterial infection of the skeleton. Trends Microbiol. 2003;11:570–7.

    Article  CAS  Google Scholar 

  24. Hendriks JGE, van Horn JR, van der Mei HC, Busscher HJ. Backgrounds of antibiotic loaded bone cement and prosthesis related infection. Biomaterials. 2004;25:545–56.

    Article  CAS  Google Scholar 

  25. Hunter G, Dandy D. The natural history of the patient with a total hip replacement. J Bone Joint Surg Br. 1977;59:293–7.

    Article  CAS  Google Scholar 

  26. Imazato S, Russel RR, McCabe JF. Antibacterial activity of MDPB polymer incorporated in dental resin. J Dent. 1995;23:177–81.

    Article  CAS  Google Scholar 

  27. Mah TF, O’Toole GA. Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol. 2001;9:34–9.

    Article  CAS  Google Scholar 

  28. Matharu S, Spratt DA, Pratten J, Ng YL, Mordan N, Wilson M, Gulabivala K. A new in vitro model for the study of microbial microleakage around dental restorations: a preliminary qualitative evaluation. Int Endod J. 2001;34:547–53.

    Article  CAS  Google Scholar 

  29. Modak SM, Fox CL. Binding of silver sulfadiazine to cellular components of Pseudomonas-aeruginosa. Biochem Pharmacol. 1973;22:2391–404.

    Article  CAS  Google Scholar 

  30. Nicholson JW. Chemistry of glass-ionomer cements: a review. Biomaterials. 1998;19:485–94.

    Article  CAS  Google Scholar 

  31. O’Brien WJ. Dental materials and their selection. 2nd ed. Chicago: Quintessence; 1997. p. 97–113.

    Google Scholar 

  32. Palmer G, Jones FH, Billington RW, Pearson GJ. Chlorhexidine release from an experimental glass ionomer cement. Biomaterials. 2004;25:5423–31.

    Article  CAS  Google Scholar 

  33. Potera C. Microbiology – forging a link between biofilms and disease. Science. 1999;283:1837–8.

    Article  CAS  Google Scholar 

  34. Riedl CR, Plas E, Hubner WA, Zimmerl H, Ulrich W, Pfluger H. Bacterial colonization of ureteral stents. Eur Urol. 1999;36:53–9.

    Article  CAS  Google Scholar 

  35. Salvati EA, Gonzalez Della Valle A, Masri BA, Duncan CP. The infected total hip arthroplasty. Instr Course Lect. 2003;42:223–345.

    Google Scholar 

  36. Sanders BJ, Gregory RL, Moore K, Avery DR. Antibacterial and physical properties of resin modified glass-ionomers combined with chlorhexidine. J Oral Rehabil. 2002;29:553–8.

    Article  CAS  Google Scholar 

  37. Schierholz JM, Beuth J. Implant infections: a haven for opportunistic bacteria. J Hosp Infect. 2001;49:87–93.

    Article  CAS  Google Scholar 

  38. Splieth C, Bernhardt O, Heinrich A, Bernhardt H, Meyer G. Anaerobic microflora under class I and class II composite and amalgam restorations. Quintessence Int. 2003;34:497–503.

    Google Scholar 

  39. Stickler DJ. Biomaterials to prevent nosocomial infections: is silver the gold standard? Curr Opin Infect Dis. 2000;13:389–93.

    Article  CAS  Google Scholar 

  40. Su SH, Conroy S, Lin TL, Sheu MS, Loh IH. Surface coatings. In: Wnek GE, Bowlin GL, editors. Encyclopedia of biomaterials and biomedical engineering. New York: Marcel Dekker Inc; 2004.

    Google Scholar 

  41. Wang CJ, Huang TW, Wang JW, Chen HS. The often poor clinical outcome of infected total knee arthroplasty. J Arthroplast. 2002;17:608–14.

    Article  Google Scholar 

  42. Wilson M. Bacterial biofilms and human disease. Sci Prog. 2001;84:235–54.

    Article  CAS  Google Scholar 

  43. Xu X, Burgess JO. Compressive strength, fluoride release and recharge of fluoride-releasing materials. Biomaterials. 2003;24:2451–61.

    Article  CAS  Google Scholar 

  44. Yoshida K, Tanagawa M, Atsuta M. Characterization and inhibitory effect of antibacterial dental resin composites incorporating silver-supported materials. J Biomed Mater Res. 1999;47:516–22.

    Article  CAS  Google Scholar 

  45. Young AM, Leung D, Ho S, Rafeeka SA, Pratten J, Spratt DA, Gulabivala K. Chemical, mechanical and biological studies of new antibacterial aesthetic restorative materials. Shawbury: Medical Polymers, Rapra Technology Ltd; 2003.

    Google Scholar 

  46. Young AM, Leung D, Ho S, Sheung Y, Pratten J, Spratt DA. New injectable antibacterial polymers for bone and tooth repair. Shawbury: Medical Polymers, Rapra Technology Ltd; 2004.

    Google Scholar 

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Correspondence to Showan N. Nazhat .

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Nazhat, S.N., Young, A.M., Pratten, J. (2021). Sterility and Infection. In: Narayan, R. (eds) Biomedical Materials. Springer, Cham. https://doi.org/10.1007/978-3-030-49206-9_20

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